10-Phenylphenothiazine-Organophotocatalyzed Bromo-Perfluoroalkylation of Unactivated Olefins

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(10), P. 7084 - 7094

Published: April 25, 2024

In this study, we have developed a smooth metal-free visible-light-induced bromo-perfluoroalkylation of unactivated olefins with the aid 10-phenylphenothiazine (PTH) as an organic photoredox catalyst. The reaction is 100% atom-economic redox-neutral and proceeds stoichiometric amounts olefin perfluoroalkyl bromide. To show potential these unexplored motifs, carried out various postfunctionalizations taking advantage bromine atom, including gram-scale experiments.

Language: Английский

Bayesian optimization assisted screening conditions for visible light-induced hydroxy-perfluoroalkylation

Journal of Fluorine Chemistry, Journal Year: 2024, Volume and Issue: 276, P. 110294 - 110294

Published: May 1, 2024

The reaction conditions for the visible light-induced hydroxy-perfluoroalkylation of olefins were explored using Bayesian optimization (BO). This is first application BO to photoreaction synthesis fluorinated compounds. Five parameters, including light irradiation intensity, simultaneously examined, thereby enabling investigation minimal experimentation. key parameters identified by calculating correlation coefficients each parameter. Furthermore, individual achieved different and perfluoroalkyl bromides.

Language: Английский

Visible-light-induced photocatalytic iododi(per)fluoroalkylation of 5-amino-N-allyl-1,2,3-triazole-4-carboxamides

Journal of Fluorine Chemistry, Journal Year: 2024, Volume and Issue: 276, P. 110292 - 110292

Published: April 24, 2024

Language: Английский