Recent Insights on the Prospective role of Phytocompounds in Modulating Gut-Brain Axis DOI
Nitu Kumari, Santosh Anand, Kamal Shah

et al.

Current Pharmacology Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 4, 2024

Language: Английский

Advancements in the Cultivation, Active Components, and Pharmacological Activities of Taxus mairei DOI Creative Commons
Xinyu Gao,

Ni Zhang,

Weidong Xie

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 1128 - 1128

Published: March 2, 2024

Taxus mairei (Lemée and H.Lév.) S.Y.Hu, indigenous to the southern regions of China, is an evergreen tree belonging genus Taxaceae family. Owing its content various bioactive compounds, it exhibits multiple pharmacological activities has been widely applied in clinical medicine. This article comprehensively discusses current state cultivation, chemical constituents, applications pharmaceutical field, challenges faced by T. mairei. The paper begins detailing ecological distribution mairei, aiming provide in-depth understanding origin cultivation overview. In terms composition, thoroughly summarizes extracts monomeric components unveiling their elucidating mechanisms action based on latest scientific research, as well potential lead compounds new drug development. also addresses such difficulties extracting synthesizing active need for sustainable utilization strategies. summary, a rare species important biodiversity conservation demonstrates significant research application development disease treatment.

Language: Английский

Citations

4
Exploration of novel phytochemicals as α-synuclein aggregation inhibitors in the context of Parkinson’s disease therapy: an in-silico approach DOI
Garima Gupta, Deepika Joshi, Gopeshwar Narayan

et al.

In Silico Pharmacology, Journal Year: 2025, Volume and Issue: 13(1)

Published: March 6, 2025

Language: Английский

Citations

0
Role and mechanism of herbal bioactives in treatment of Parkinson disease: A promising therapeutic approach DOI
Manpreet Kaur, Mukta Gupta

South African Journal of Botany, Journal Year: 2025, Volume and Issue: 181, P. 315 - 338

Published: April 25, 2025

Language: Английский

Citations

0
Antiparkinsonian Effect of Nutmeg Ethanolic Extract (Myristica fragrans Houtt.) in Haloperidol-induced Mice DOI Creative Commons
Dwi Hadi Setya Palupi,

Isma Galuh Fekhayanti

Pharmaciana, Journal Year: 2024, Volume and Issue: 14(1), P. 20 - 20

Published: March 29, 2024

Parkinson's disease is a chronic neurological illness that may be caused by decrease in dopaminergic neurons the brain. Myristicin, eugenol, and flavonoids, which are bioactive compounds nutmeg ( Myristica fragrans Houtt.), able to treat disease. The goal of this study was find out antiparkinsonian effect haloperidol-induced mice. Induction with haloperidol carried intraperitoneally for 7 consecutive days. Treatment uses three different doses (5, 10, 20 mg/kg) days orally. Behavioral testing using Rotarod test cylinder test. results showed at dose mg/kg show significant improvement (P < 0.05) motor condition animals induced haloperidol.

Language: Английский

Citations

0
Apoptotic: In-silico and In-vitro Study on Alzheimer’s Marker, and Bioactive Derived from Benincasa hispida using Gas Chromatography-Mass Spectroscopy DOI Creative Commons
Pooja RC,

Bharathi DR

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 6, 2024

Abstract Purpose: Molecular docking is a viable and useful method to develop new herbal therapies fulfill different therapeutic needs. One of the biggest issues lack understanding processes underlying common use herbs. Method: Potential binding sites between ligands target protein were loaded using Schrodinger software, which also predicts protein-ligand interactions. The forty (40) molecules Benincasa hispida with Apoptosis Acetylcholine targets carried out so, as evaluate their theoretical affinities. chemical structure was predicted from gas-chromatography (GC-MS), National Institute Standards Technology (NIST) library (2014). Molecule 40 (M40) highest affinity -10 kcal/mol observed. In-silico ADME drug-likeness prediction showed good pharmacokinetic properties having high gastrointestinal absorption, orally bioavailable, less toxic. Results: Phytochemical screening, In-vitro analysis free radical scavenging assay (DPPH, ABTS, H2O2, FRAP). Phytochemical screening presence flavonoids, terpenoids, Phenols, sterols, glycosides observed in preliminary test. In assay, Ascorbic acid regression values DPPH (R2=0.9746), ABTS (R2=0.9865), H2O2 (R2=0.988), FRAP (R2=0.9834). Conclusion: outcome present research strengthens relevance these compounds promising lead candidates for treatment multidrug-resistant Alzheimer's disease could help medicinal chemists pharmaceutical professionals further designing synthesis more potent drug candidates. Moreover, encouraged in-vivo in-vitro evaluation study proposed designed validate computational findings.

Language: Английский

Citations

0
In vitro neuroprotective effects and in silico evaluation of the pharmacological potential of two phenolic acids and a derivative originated from the edible red macroalga (Bangia fuscopurpurea) DOI Creative Commons
Shiying Huang, Chang‐Wei Hsieh, Chien‐Wei Feng

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 119, P. 106322 - 106322

Published: June 25, 2024

Language: Английский

Citations

0
Phytochemical Importance of Medicinal Plants as Potential Sources Against Neurodegenerative Diseases DOI
Vibha Pandey, Debasis Chakrabarty

Published: Jan. 1, 2024

Language: Английский

Citations

0
Recent Insights on the Prospective role of Phytocompounds in Modulating Gut-Brain Axis DOI
Nitu Kumari, Santosh Anand, Kamal Shah

et al.

Current Pharmacology Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 4, 2024

Language: Английский

Citations

0