Exploring the anti-inflammatory effects of phytochemicals in attenuating interstitial cystitis-a literature review

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 5, 2025

Interstitial cystitis is a fierce syndrome affecting the quality of life thousands individuals around globe. It causes immense pain in bladder and associated viscera along with inflammation-like lesions. The current medicinal pharmacological research focuses on protective curative effects phytochemicals several ailments. Phytochemicals derived from many plants have shown potent outcomes protection against various pathological conditions including interstitial cystitis. This review has summarized insights vitro vivo studies regarding fading inflammation tissue exhibiting effect urothelium. Hemorrhagic common manifestation patients undergoing chemotherapy cyclophosphamide related alkylating agents. Sodium 2-mercaptoethane sulfonate (Mesna) traditionally been employed clinical practice to counter cyclophosphamide-induced humans. However, developing animal models studies. quercetin, beta-caryophyllene, curcumol, boswellic acid, caftaric some flavonoids other secondary metabolites being consequential component numerous plants, displayed significant reduction levels proinflammatory cytokines TNF-α, NFĸB, IL-1β, NLRP3 inflammasome, IL-6, IL-2, matrix metalloproteinases etc. Uroprotective these found result diminished oxidative stress restoration glutathione, superoxide dismutase, proteins inflamed tissue. Many involving confirmed findings. coupling phytotherapy novel drug delivery systems such as nanoparticles, liposomes, nanotubes, quantum dots, can help translate beneficial into practice. Further investigations provide intuition development newer molecules having exclusive activity for attenuating

Language: Английский

---

From Nature to Nanotech: Unlocking Berberine’s Therapeutic Approaches

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106924 - 106924

Published: April 1, 2025

Language: Английский

---

Gut microbiota: A potential enhancing factor for the therapeutic efficacy of bioactive compounds in herbal medicines

Fitoterapia, Journal Year: 2025, Volume and Issue: 183, P. 106570 - 106570

Published: April 25, 2025

Language: Английский

---

Characterization of active alkaloids and metabolites in rats after oral administration of Zuojin Pill using UHPLC-Q-TOF-MS combined with bioinformatics and molecular docking analyses

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2024, Volume and Issue: 249, P. 116340 - 116340

Published: July 4, 2024

Language: Английский

---