Multifunctional scaffolds for bone repair following age-related biological decline: Promising prospects for smart biomaterial-driven technologies

Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122683 - 122683

Published: June 28, 2024

Language: Английский

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Advances in self-assembled nanotechnology in tumor therapy

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 237, P. 113838 - 113838

Published: March 11, 2024

Language: Английский

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Selenopeptide nanomedicine ameliorates atherosclerosis by reducing monocyte adhesions and inflammations

Nano Research, Journal Year: 2024, Volume and Issue: 17(7), P. 6332 - 6341

Published: March 13, 2024

Language: Английский

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Photothermal-Magnetic Driven Post-Targeting Retention and Cascade Therapy of “Biomimetic Glue”-Based Nanoreactor for Cancer Theranostics by Bystander-Like Killing

Published: Jan. 1, 2025

Language: Английский

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Nanoimmunotherapy: the smart trooper for cancer therapy

Exploration of Targeted Anti-tumor Therapy, Journal Year: 2025, Volume and Issue: 6

Published: April 10, 2025

Immunotherapy has gathered significant attention and is now a widely used cancer treatment that uses the body's immune system to fight cancer. Despite initial successes, its broader clinical application hindered by limitations such as heterogeneity in patient response challenges associated with tumor microenvironment. Recent advancements nanotechnology have offered innovative solutions these barriers, providing enhancements immunotherapy. Nanotechnology-based approaches exhibit multifaceted mechanisms, including effective anti-tumor responses during tumorigenesis overcoming suppression mechanisms improve defense capacity. Nanomedicines, nanoparticle-based vaccines, liposomes, modulators, gene delivery systems, demonstrated ability activate responses, modulate microenvironments, target specific cells. Success metrics preclinical early studies, improved survival rates, enhanced regression, elevated activation indices, highlight promise of technologies. achievements, several remain, scaling up manufacturing, addressing off-target effects, navigating regulatory complexities. The review emphasizes need for interdisciplinary address ensuring adoption. It also provides insights into approaches, advancements, transformative potential nano-immunotherapy promising results checkpoint inhibitor delivery, nanoparticle-mediated photothermal therapy, immunomodulation well inhibition nanoparticles vaccines.

Language: Английский

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Photothermal-magnetic driven post-targeting retention and cascade therapy of “biomimetic glue”-based nanoreactor for cancer theranostics by bystander-like killing

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162784 - 162784

Published: April 1, 2025

Language: Английский

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Nanomedicine for cancer patient‐centered care

MedComm, Journal Year: 2024, Volume and Issue: 5(11)

Published: Oct. 20, 2024

Abstract Cancer is a leading cause of morbidity and mortality worldwide, an increase in incidence estimated the next future, due to population aging, which requires development highly tolerable low‐toxicity cancer treatment strategies. The use nanotechnology tailor treatments according genetic immunophenotypic characteristics patient's tumor, allow its targeted release, can meet this need, improving efficacy minimizing side effects. Nanomedicine‐based approach for diagnosis rapidly evolving field. Several nanoformulations are currently clinical trials, some have been approved marketed. However, their large‐scale production still hindered by in‐depth debate involving ethics, intellectual property, safety health concerns, technical issues, costs. Here, we survey key approaches, with specific reference organ‐on chip technology, cutting‐edge tools, such as CRISPR/Cas9 genome editing, through nanosystems needs personalized diagnostics therapy patients. An update provided on nanopharmaceuticals marketed those undergoing trials. Finally, discuss emerging avenues field challenges be overcome transfer nano‐based precision oncology into daily life.

Language: Английский

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Nanomaterial-based detection of circulating tumor cells and circulating cancer stem cells for cancer immunotherapy

Nano Convergence, Journal Year: 2024, Volume and Issue: 11(1)

Published: Dec. 13, 2024

Abstract Nanomaterials have emerged as transformative tools for detecting circulating tumor cells (CTCs) and cancer stem (CCSCs), significantly enhancing diagnostics immunotherapy. Nanomaterials, including those composed of gold, magnetic materials, silica, enhanced the sensitivity, specificity, efficiency isolating these rare from blood. These developments are paramount importance early detection providing real-time insights into metastasis treatment resistance, which essential development personalized immunotherapies. The combination nanomaterial-based platforms with phenotyping techniques, such Raman spectroscopy microfluidics, enables researchers to enhance immunotherapy protocols targeting specific CTC CCSC markers. also facilitate targeted delivery immunotherapeutic agents, immune checkpoint inhibitors therapeutic antibodies, directly cells. This synergistic approach has potential efficacy mitigate risk relapse. In conclusion, this review critically examines use nanomaterial-driven systems CTCs CCSCs, their application in immunotherapy, suggests future directions, highlighting transform integration treatment, thereby paving way more precise therapies. Graphical

Language: Английский

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静电纺丝技术制备聚合物基MXene增强电磁屏蔽复合材料的研究进展

Scientia Sinica Technologica, Journal Year: 2024, Volume and Issue: 54(8), P. 1496 - 1518

Published: June 21, 2024

随着电子信息技术的发展,电磁波污染已经严重影响了人类健康和社会进步,因此急需开发出一种高效的电磁干扰(electromagnetic interference,EMI)屏蔽材料。静电纺丝技术可以制备出柔韧性好的超薄多孔纤维膜,电磁波能够在纤维膜内部进行多次反射而被消耗。MXene作为一种新型的二维(2D)材料群体,具有高比表面积、高导电性以及易加工性,是一种潜在的EMI屏蔽材料。因此,将静电纺丝技术和MXene材料相结合,能够制备出多功能的聚合物基MXene增强电磁屏蔽复合材料。本文首先介绍了静电纺丝技术的概念、原理及其影响因素,其次,分析了MXene材料的组成和制备方法,最后,讨论了静电纺丝技术制备聚合物基MXene增强电磁屏蔽复合材料的最新进展并对未来聚合物基MXene增强静电纺丝复合材料在电磁屏蔽领域的发展做出展望。

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