A Comprehensive Review on Circulating cfRNA in Plasma: Implications for Disease Diagnosis and Beyond

Diagnostics, Journal Year: 2024, Volume and Issue: 14(10), P. 1045 - 1045

Published: May 17, 2024

Circulating cfRNA in plasma has emerged as a fascinating area of research with potential applications disease diagnosis, monitoring, and personalized medicine. RNA sequencing technology allows for the non-invasive collection important information about expression target genes, eliminating need biopsies. This comprehensive review aims to provide detailed overview current knowledge advancements study cfRNA, focusing on its diverse landscape biological functions, detection methods, diagnostic prognostic various diseases, challenges, future perspectives.

Language: Английский

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Berberine: A multifaceted agent for lung cancer treatment-from molecular insight to clinical applications

Gene, Journal Year: 2024, Volume and Issue: unknown, P. 149021 - 149021

Published: Oct. 1, 2024

Language: Английский

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Synergistic inhibitory effect of atmospheric pressure plasma and berberine on non‑small cell lung cancer cells via inducing apoptosis

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Background Non-small cell lung cancer (NSCLC) is a type of cancer, the incidence and mortality rate have been high, use monotherapy easy to make patients develop tolerance. Atmospheric pressure plasma (APP) an emerging technology for killing cells in recent years, there are fewer studies related combination berberine mechanism action has not fully elucidated NSCLC. The article primary goal investigate effect on NSCLC its associated characterization. Methods results Antiproliferative effects were detected by MTT assay colony formation, flow cytometry analysis apoptosis cycling showed that synergistically induced apoptosis. Then, extracellular ROS levels DCFH-DA-based kits examined intracellular levels, their mitochondrial membrane potential measured. Study reveals co-induced with accumulation. Subsequently, Western blotting (WB) expression EGFR, important signaling pathway proteins Ras / ERK AKT mTOR. Results it could downregulation EGFR protein inhibit activation ERK/ pathways. Simultaneous wound healing EMT marker detection performed assessment migration ability cells. Combination therapy inhibited Conclusion this study show can induce regulating production. AKT/ERK inhibition linked synergistic effect.

Language: Английский

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Synergistic inhibitory effect of atmospheric pressure plasma and berberine on non‑small cell lung cancer cells via inducing apoptosis

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 52(1)

Published: Dec. 6, 2024

Language: Английский

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