Nanoparticles for Augmenting Therapeutic Potential and Alleviating the Effect of Di(2-ethylhexyl) Phthalate on Gastric Cancer DOI Creative Commons

Hau-Lun Huang,

Kuo-Wei Chen, Hsiao‐Wei Liao

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(15), P. 18285 - 18299

Published: April 4, 2024

Changes in diet culture and modern lifestyle contributed to a higher incidence of gastrointestinal-related diseases, including gastritis, implicated the pathogenesis gastric cancer. This observation raised concerns regarding exposure di(2-ethylhexyl) phthalate (DEHP), which is linked adverse health effects, reproductive developmental problems, inflammatory response, invasive adenocarcinoma. Research on direct link between DEHP cancer ongoing, further studies are required establish conclusive association. In our study, extremely low concentrations exerted significant effects cell migration by promoting epithelial-mesenchymal transition cells. effect was mediated modulation PI3K/AKT/mTOR Smad2 signaling pathways. To address challenges, initial design TPGS-conjugated fucoidan, delivered via pH-responsive nanoparticles, successfully demonstrated binding P-selectin protein. achievement has not only enhanced antigastric tumor efficacy but also led reduction expression malignant proteins associated with condition. These findings underscore promising clinical therapeutic potential approach.

Language: Английский

Recent Technological and Intellectual Property Trends in Antibody–Drug Conjugate Research DOI Creative Commons
Youngbo Choi, Y. Choi,

Surin Hong

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 221 - 221

Published: Feb. 3, 2024

Antibody–drug conjugate (ADC) therapy, an advanced therapeutic technology comprising antibodies, chemical linkers, and cytotoxic payloads, addresses the limitations of traditional chemotherapy. This study explores key elements ADC focusing on antibody development, linker design, payload delivery. The global rise in cancer incidence has driven increased investment anticancer agents, resulting significant growth therapy market. Over past two decades, notable progress been made, with approvals for 14 treatments targeting various cancers by 2022. Diverse therapies hematologic malignancies solid tumors have emerged, numerous candidates currently undergoing clinical trials. Recent years seen a noteworthy increase trials, marked initiation new Research coupled patent applications, intensified, notably from major companies like Pfizer Inc. (New York, NY, USA), AbbVie Pharmaceuticals (USA), Regeneron (Tarrytown, Seagen (Bothell, WA, USA). While holds great promise treatment, challenges persist, including premature release immune-related side effects. Ongoing research innovation are crucial advancing therapy. Future developments may include novel conjugation methods, stable designs, efficient delivery technologies, integration nanotechnology, driving evolution treatment.

Language: Английский

Citations

8
The Importance of Antibody Orientation for Enhancing Sensitivity and Selectivity in Lateral Flow Immunoassays DOI Creative Commons

Zhao-Yu Lu,

Yang-Hsiang Chan

Sensors & Diagnostics, Journal Year: 2024, Volume and Issue: 3(10), P. 1613 - 1634

Published: Jan. 1, 2024

This review emphasized the crucial role of antibody orientation in enhancing sensitivity and selectivity lateral-flow assay test strips.

Language: Английский

Citations

4
The role of potential oxidative biomarkers in the prognosis of intracerebral hemorrhage and the exploration antioxidants as possible preventive and treatment options DOI Creative Commons

Jiayong Yao,

Xiaohong Dai,

Xueping Yv

et al.

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 4, 2025

Intracerebral hemorrhage (ICH) is a non traumatic that occurs in certain part of the brain. It usually leads to brain cell damage. According large number experimental research, oxidative stress an important pathophysiological processes cerebral hemorrhage. In this paper, we aim determine how changes biomarkers indicate damage degree hemorrhage, and explore summarize potential treatments or interventions. We found patients with are characterized by increased levels markers, such as total malondialdehyde (MDA), F2 isoprostaglandin, hydroxynonenal, myeloperoxidase protein hydroxyl. Therefore, caused ICH on these markers can be used evaluate diagnose ICH, predict its prognosis, guide preventive treatment turn antioxidant based new alternative.

Language: Английский

Citations

0
Nanoparticles for Augmenting Therapeutic Potential and Alleviating the Effect of Di(2-ethylhexyl) Phthalate on Gastric Cancer DOI Creative Commons

Hau-Lun Huang,

Kuo-Wei Chen, Hsiao‐Wei Liao

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(15), P. 18285 - 18299

Published: April 4, 2024

Changes in diet culture and modern lifestyle contributed to a higher incidence of gastrointestinal-related diseases, including gastritis, implicated the pathogenesis gastric cancer. This observation raised concerns regarding exposure di(2-ethylhexyl) phthalate (DEHP), which is linked adverse health effects, reproductive developmental problems, inflammatory response, invasive adenocarcinoma. Research on direct link between DEHP cancer ongoing, further studies are required establish conclusive association. In our study, extremely low concentrations exerted significant effects cell migration by promoting epithelial-mesenchymal transition cells. effect was mediated modulation PI3K/AKT/mTOR Smad2 signaling pathways. To address challenges, initial design TPGS-conjugated fucoidan, delivered via pH-responsive nanoparticles, successfully demonstrated binding P-selectin protein. achievement has not only enhanced antigastric tumor efficacy but also led reduction expression malignant proteins associated with condition. These findings underscore promising clinical therapeutic potential approach.

Language: Английский

Citations

3