Antioxidants,
Journal Year:
2024,
Volume and Issue:
14(1), P. 32 - 32
Published: Dec. 29, 2024
Ginseng
has
multi-directional
pharmacological
properties.
Some
data
suggest
that
ginseng
can
enhance
physical
endurance,
which,
in
turn,
leads
to
protection
of
the
cardiovascular
system.
However,
not
all
experiments
are
conclusive.
For
this
reason,
main
aim
research
was
perform
a
meta-analysis
and
review
studies
published
between
years
2013
2023
concerning
effect
on
performance
animal
human
models.
Medline,
Pubmed,
ClinicalKey
electronic
databases
were
used
analyze
data.
The
search
strategy
included
following
criteria:
exercise;
supplementation;
supplements.
results
supplementation
may
have
positive
CK
levels
studies.
Similar
observations
stated
relation
serum
lactate
BUN.
Furthermore,
study
showed
significant
increase
exercise
time
exhaustion
VO2
max
after
supplementation.
literature
conducted
identified
endurance.
Due
fact
most
current
based
models,
further
models
is
needed
identify
effective
dosage
or
form
applied
be
supportive
element
CVD
management.
Frontiers in Aging Neuroscience,
Journal Year:
2024,
Volume and Issue:
16
Published: May 22, 2024
Introduction
Gastrodia
elata
is
the
dried
tuber
of
orchid
Bl.
It
considered
a
food
consisting
source
precious
medicinal
herbs,
whose
chemical
composition
relatively
rich.
and
its
extracted
fractions
have
been
shown
to
neuroprotective
effects.
P
-hydroxybenzaldehyde
(
p
-HBA),
as
one
main
active
components
,
has
anti-inflammatory,
antioxidative
stress,
cerebral
protective
effects,
which
potential
for
treatment
Alzheimer’s
disease
(AD).
The
aim
this
study
was
verify
role
-HBA
in
AD
investigate
mechanism
action
depth
based
using
Caenorhabditis
elegans
C.
)
model.
Methods
In
study,
we
used
paralysis,
lifespan,
behavioral
antistress
experiments
effects
on
aging.
Furthermore,
performed
reactive
oxygen
species
(ROS)
assay,
thioflavin
S
staining,
RNA-seq
analysis,
qPCR
validation,
PCR
Array,
GFP
reporter
gene
worm
experiment
determine
anti-AD
-HBA,
well
in-depth
studies
mechanisms.
Results
able
delay
improve
mobility
resistance
aging
nematode
Further
mechanistic
showed
that
ROS
lipofuscin
levels,
Aβ
aggregation,
toxicity
were
reduced
after
treatment,
suggesting
ameliorated
Aβ-induced
by
enhancing
antioxidant
anti-aging
activity
inhibiting
aggregation.
had
therapeutic
effect
improving
stress
resistance,
indicated
down-regulation
NLP-29
UCR-11
expression
up-regulation
PQN-75
LYS-3
expression.
addition,
microarray
played
positive
genes
related
AD,
anti-aging,
ribosomal
protein
pathway,
glucose
metabolism,
collectively
involved
-HBA.
Finally,
also
found
promoted
nuclear
localization
DAF-16
increased
SKN-1,
SOD-3,
GST-4,
contributed
significantly
inhibition
enhancement
stress.
Conclusion
Our
work
suggests
some
activities.
may
be
viable
candidate
prevention
disease.
International Journal of General Medicine,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 529 - 565
Published: Feb. 1, 2025
Abstract:
Allergic
rhinitis
(AR)
is
a
prevalent
allergic
disease
that
imposes
significant
economic
burdens
and
life
pressures
on
individuals,
families,
society,
particularly
in
the
context
of
accelerating
globalization
increasing
pathogenic
factors.
Current
clinical
therapies
for
AR
include
antihistamines,
glucocorticoids
administered
via
various
routes,
leukotriene
receptor
antagonists,
immunotherapy,
several
decongestants.
These
treatments
have
demonstrated
efficacy
alleviating
symptoms
pathological
states.
However,
with
growing
awareness
rising
expectations
improvements
quality
life,
these
become
associated
higher
incidence
side
effects
an
elevated
risk
drug
resistance.
Furthermore,
development
intricately
dysregulation
immune
system,
yet
underlying
pathogenetic
mechanisms
remain
incompletely
understood.
In
contrast,
widely
available
natural
plant
molecules
offer
multiple
targeting
pathways
uniquely
modify
typical
pathophysiology
through
immunomodulatory
processes.
This
review
presents
comprehensive
analysis
both
vivo
vitro
studies
modulate
immunity
treating
AR.
Additionally,
we
examine
their
specific
action
animal
models
to
provide
new
insights
developing
safe
effective
targeted
while
guiding
experimental
applications
against
Keywords:
molecules,
rhinitis,
immunomodulation,
therapeutic
mechanism,
research
progress
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 25, 2025
Vascular
dementia
(VD)
is
a
neurodegenerative
disease
caused
by
chronic
cerebral
hypoperfusion
(CCH),
which
considerably
impact
patients'
quality
of
life.
Ethanol
extraction
from
Rubia
yunnanensis
(RY-A)
has
gained
attention
for
its
potential
neuroprotective
effects,
but
effects
and
mechanisms
action
on
CCH
are
unknown.
After
30
days
RY-A
gavage
treatment
in
rat
model,
were
evaluated
using
the
Morris
water
maze
test,
blood
flow
measurements,
HE
staining
brain.
These
findings,
combined
with
serum
medicinal
chemistry,
RNA-seq,
metabolomics
analyses,
revealed
active
compounds
rats.
The
results
further
validated
assay
kits
Western
blot
techniques.
significantly
attenuated
neurological
damage
improved
cognitive
function
Ultra-high-performance
liquid
chromatography
high-resolution
mass
spectrometry
identified
511
blood-entry
RY-A.
RNA-seq
metabolomic
analysis
showed
that
might
help
to
normalize
changes
gene
metabolite
expression
CCH.
induced
increasing
production
key
proteins
involved
ferroptosis
inhibition,
such
as
SLC7A11,
SLC3A2,
GSS,
GPX4,
while
antioxidant
enzyme
activities
alleviating
oxidative
stress.
inhibited
stress
activating
System
Xc-/GSH/GPX4
pathway
balancing
iron
metabolism,
thereby
attenuating
CCH-induced
deficits.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 16, 2025
This
review
provides
an
in-depth
exploration
of
the
potential
Ginsenoside
Rg1
in
treatment
Parkinson's
disease
(PD).
The
emphasis
this
article
was
therapeutic
mechanisms
Rg1,
which
involved
reduction
inflammation,
antioxidant
properties,
support
for
neuronal
survival
and
regeneration,
regulation
cellular
energy
processes,
enhancement
autophagic
pathways.
may
protect
neurons
improve
both
motor
cognitive
impairments
associated
with
PD
through
multiple
mechanisms.
However,
challenges
exist
clinical
application
such
as
low
bioavailability
well
a
lack
comprehensive
long-term
safety
efficacy
data.
also
reviewed
network
pharmacology
analyses
published
previously
to
identify
explore
molecular
targets
treatment,
while
evaluating
strategies
drug
delivery
technologies,
optimizing
administration
routes,
combination
therapies.
Ultimately,
highlights
necessity
large-scale
trials
validate
discusses
its
clinically.
Brain Injury,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 17
Published: April 21, 2025
TBI's
intricate
pathophysiology,
which
includes
oxidative
stress,
neuroinflammation,
apoptosis,
and
mechanical
injury,
makes
it
a
serious
public
health
concern.
Although
stabilization
secondary
damage
management
are
the
main
goals
of
current
treatments,
their
efficacy
is
still
restricted.
The
potential
for
improving
patient
outcomes
by
combining
phytochemicals
with
traditional
medicines
examined
in
this
review.
study
neuroprotective
qualities
ginsenosides,
ginkgolides,
resveratrol,
curcumin
as
well
antioxidant
anti-inflammatory
activities.
Analysis
was
done
on
molecular
pathways
medication
delivery
techniques
to
improve
translational
drug
availability
clinical
practice.
Phytochemical
substances
directly
influence
TBI-related
neurogenic
functional
restoration
while
also
affecting
subsequent
neural
processes.
Particle-based
medicine
platforms
enhance
therapeutic
efficacy,
emerging
innovative
solutions
targeted
delivery.
When
medical
therapies
integrate
phytochemicals,
becomes
possible
achieve
better
results
through
enhanced
synergy.
This
review
uniquely
integrates
standard
TBI
emphasizing
advanced
strategies
neuroprotection
outcomes.
Unlike
previous
studies,
explores
novel
platforms,
such
nanoparticle-based
systems,
highlights
synergy
between
conventional
recovery.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 1, 2024
Currently,
traditional
Chinese
medicine
(TCM)
and
its
combinations
are
widely
used
in
the
treatment
rehabilitation
of
patients
with
ischemic
stroke.
However,
current
studies
should
mainly
focus
on
therapeutic
effects
medicines
alone.
This
paper
will
employ
a
network
meta-analysis
to
compare
efficacy
different
TCM
decoctions
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 30, 2024
ABSTRACT
Ginseng
is
a
kind
of
traditional
Chinese
medicine.
It
widely
believed
that
ginseng
can
improve
cognitive
function,
but
its
clinical
efficacy
still
controversial.
This
study
aimed
to
systematically
evaluate
the
effects
on
function
improvement.
systematic
review
and
meta‐analysis
randomized
controlled
trials
(RCTs).
Searching
PubMed,
Web
Science,
Cochrane
Library,
Medline
databases
collect
RCTs
human
function.
The
time
range
from
establishment
database
December
2023.
main
intervention
in
was
preparation.
risk‐of‐bias
tool
2.0
(RoB2.0)
Jadad
scale
were
used
assess
risk
bias
quality
included
articles.
After
data
extraction,
performed
using
Stata
17.0
software.
A
total
15
included,
671
patients
analyzed.
subjects
healthy
people,
impairment,
schizophrenia,
hospitalized,
Alzheimer's
disease.
measures
mainly
preparations.
results
indicated
has
significant
effect
memory
improvement
(SMD
=
0.19,
95%CI:
0.02–0.36,
p
<
0.05),
especially
at
high
doses
0.33,
0.04–0.61,
0.05).
did
not
have
positive
overall
cognition,
attention,
executive
0.06,
−0.64–0.77,
0.86;
SMD
−0.12
0.23,
0.54;
−0.03,
−0.28
0.21,
0.79).
some
improvement,
But
future,
more
high‐quality
studies
are
needed
determine
Trial
Registration:
Prospero:
CRD42024514231
