Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 924 - 924

Published: March 23, 2024

Chlorogenic acid (CGA) is a type of polyphenol compound found in rich concentrations many plants such as green coffee beans. As an active natural substance, CGA exerts diverse therapeutic effects response to variety pathological challenges, particularly conditions associated with chronic metabolic diseases and age-related disorders. It shows multidimensional functions, including neuroprotection for neurodegenerative disorders diabetic peripheral neuropathy, anti-inflammation, anti-oxidation, anti-pathogens, mitigation cardiovascular disorders, skin diseases, diabetes mellitus, liver kidney injuries, anti-tumor activities. Mechanistically, its integrative functions act through the modulation anti-inflammation/oxidation homeostasis. can thwart inflammatory constituents at multiple levels curtailing NF-kB pathways neutralize primitive factors, hindering propagation, alleviating inflammation-related tissue injury. concurrently raises pivotal antioxidants by activating Nrf2 pathway, thus scavenging excessive cellular free radicals. elevates AMPK maintenance restoration homeostasis glucose lipids. Additionally, neuromodulation targeting neuroreceptors ion channels. In this review, we systematically recapitulate CGA’s pharmacological activities, medicinal properties, mechanistic actions potential agent. Further studies defining specific molecules, improving bioavailability, validating clinical efficacy are required corroborate CGA.

Language: Английский

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Effects of 3-(4-Hydroxy-3-methoxyphenyl)propionic Acid on Regulating Oxidative Stress and Muscle Fiber Composition

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 668 - 668

Published: Feb. 13, 2025

Background/Objectives: Our previous study demonstrated that 3-(4-hydroxy-3-methoxyphenyl)propionic acid (HMPA) administration improved grip strength and reduced blood urea nitrogen levels, but its underlying mechanisms remain unclear. This aimed to investigate the effects of HMPA on oxidative stress muscle fiber composition, emphasizing potential role in modulating redox signaling pathways influencing development. Methods: Eight-week-old male C57BL/6 mice were orally administered solution (50 or 500 mg/kg/day) distilled water (10 mL/kg) for 14 days, then divided into sedentary exhaustive exercise groups evaluate status, myosin heavy chain (MHC) isoform expression, mechanisms. Results: Both low high doses by decreasing plasma reactive oxygen metabolites. High-dose nitrite/nitrate levels enhanced antioxidant capacity post-exercise, accompanied changes mRNA abundance enzymes (e.g., Sod1 Nqo1) reductions nitric oxide synthases Nos2 Nos3) soleus. Additionally, high-dose increased protein expression MYH4 soleus, while low-dose gene Myh4 Igf1, suggesting may promote fast-twitch hypertrophy through activation IGF-1 pathway. Furthermore, significantly Sirt1 Nrf1, as well AMPK phosphorylation improve mitochondrial biogenesis adaptation. Conclusions: These findings suggest serve a dietary supplement regulate balance, enhance defenses, formation fibers.

Language: Английский

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The colonic polyphenol catabolite dihydroferulic acid (DHFA) regulates macrophages activated by oxidized LDL, 7-ketocholesterol, and LPS switching from pro- to anti-inflammatory mediators

Food & Function, Journal Year: 2024, Volume and Issue: 15(20), P. 10399 - 10413

Published: Jan. 1, 2024

Macrophage activation plays a central role in the development of atherosclerotic plaques.

Language: Английский

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A critical examination of human data for the biological activity of phenolic acids and their phase-2 conjugates derived from dietary (poly)phenols, phenylalanine, tyrosine and catecholamines

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 60

Published: Oct. 9, 2024

Free or conjugated aromatic/phenolic acids arise from the diet, endogenous metabolism of catecholamines (adrenaline, noradrenaline, dopamine), protein (phenylalanine, tyrosine), pharmaceuticals (aspirin, metaprolol) plus gut microbiota dietary (poly)phenols and undigested protein. Quantitative data obtained with authentic calibrants for 112 including phase-2 conjugates in human plasma, urine, ileal fluid, feces tissues have been collated mean/median values compared

Language: Английский

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Antioxidant and Anti-Inflammatory Effects of Nettle Polyphenolic Extract: Impact on Human Colon Cells and Cytotoxicity Against Colorectal Adenocarcinoma

Molecules, Journal Year: 2024, Volume and Issue: 29(21), P. 5000 - 5000

Published: Oct. 22, 2024

L. is one of the most widely utilized medicinal plants commonly applied in form tea, juice, and dietary supplements. This study aimed to assess effect

Language: Английский

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The effect of maternal dietary polyphenol consumption on offspring metabolism

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 18

Published: Dec. 19, 2024

The early intrauterine environment of mothers during pregnancy significantly affects the metabolic health their offspring. Existing studies suggest that poor maternal nutrition increases risk obesity or diabetes in offspring, so it is highly important to intervene prevent disorders and Polyphenols with anti-inflammatory antioxidant properties are found many foods have protective effects on obesity, diabetes, cancer, cardiovascular disease. Furthermore, recent evidence indicates dietary polyphenols could be a potential therapy for improving outcomes offspring metabolism. In this review, we discuss mechanisms different kinds lactation metabolism analyze limitations current studies, propose possible directions further research, which provide new ideas reducing diseases

Language: Английский

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