Centipeda minima extracts and the active sesquiterpene lactones have therapeutic efficacy in non-small cell lung cancer by suppressing Skp2/p27 signaling pathway DOI
Haifang Wang,

Pei‐En Wu,

Wei He

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 340, P. 119277 - 119277

Published: Dec. 23, 2024

Language: Английский

Centipeda minima extract exhibits anti-liver cancer effects via the ER stress/HMOX1/Fe2+/ROS pathway DOI

Jinrui Wei,

Xuqi Zhao,

Boquan Wu

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156487 - 156487

Published: Feb. 11, 2025

Language: Английский

Citations

0
Arnicolide D: a multi-targeted anticancer sesquiterpene lactone—preclinical efficacy and mechanistic insights DOI

Shivaprasad Shetty Mangalpady,

Sheila I. Peña‐Corona, Fabiola V. Borbolla-Jiménez

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(9), P. 6317 - 6336

Published: April 23, 2024

Language: Английский

Citations

3
Network pharmacology and molecular docking analysis predict the mechanisms of Huangbai liniment in treating oral lichen planus DOI Creative Commons
Wei San Chang, Jing Shi,

Lingzhi Li

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(33), P. e39352 - e39352

Published: Aug. 16, 2024

This study explored the mechanism of Huangbai liniment (HB) for treatment oral lichen planus (OLP) through network pharmacology and molecular docking techniques. The identified HB’ active ingredients, therapeutic targets OLP, associated signaling pathways. chemical composition HB was screened using HERB database. disease OLP were obtained GeneCards OMIM databases. A protein–protein interactions constructed with String platform. Topological analysis performed Cytoscape software to identify core targets. Gene ontology Kyoto encyclopedia genes genomes pathway enrichment Hiplot database, ingredients verified by docking. Date showed that in quercetin, wogonin, kaempferol, luteolin. survey 10 potential targets, including TNF, CXCL8, IL-6, IL1B, PIK3R1, ESR1, JUN, AKT1, PIK3CA, CTNNB1. Molecular revealed stable between OLP’ key HB. These predominantly involved PI3K–Akt pathway, AGE–RAGE TNF HIF-1 pathway. plays a crucial role acting on multiple pathways, particularly It regulated biological processes like proliferation epithelial cells lymphocytes mediates expression transcription factors, cytokines, chemokines. Therefore, this provides theoretical basis clinical trial application therapy OLP.

Language: Английский

Citations

2
Centipeda minima extracts and the active sesquiterpene lactones have therapeutic efficacy in non-small cell lung cancer by suppressing Skp2/p27 signaling pathway DOI
Haifang Wang,

Pei‐En Wu,

Wei He

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 340, P. 119277 - 119277

Published: Dec. 23, 2024

Language: Английский

Citations

1