Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(6), P. 688 - 688
Published: June 3, 2024
Cardiovascular
diseases
stand
as
the
predominant
global
cause
of
mortality,
exerting
a
profound
impact
on
both
life
expectancy
and
its
quality.
Given
their
immense
public
health
burden,
extensive
efforts
have
been
dedicated
to
comprehending
underlying
mechanisms
developing
strategies
for
prevention
treatment.
Selenium,
crucial
participant
in
redox
reactions,
emerges
notable
factor
maintaining
myocardial
cell
homeostasis
influencing
progression
cardiovascular
disorders.
Some
disorders,
such
Keshan
disease,
are
directly
linked
with
environmental
deficiency.
Nevertheless,
precise
extent
system
remains
unclear,
marked
by
contradictory
findings
existing
literature.
High
selenium
levels
associated
an
increased
risk
hypertension,
while
lower
concentrations
heart
failure
atrial
fibrillation.
Although
some
trials
shown
potential
effectiveness
specific
groups
patients,
large
cohort
supplementation
attempts
generally
yielded
unsatisfactory
outcomes.
Consequently,
there
persists
significant
need
further
research
aimed
at
delineating
patient
cohorts
that
would
benefit
from
supplementation.
Foods,
Journal Year:
2024,
Volume and Issue:
13(3), P. 405 - 405
Published: Jan. 26, 2024
Chlorella
has
been
applied
in
the
production
of
selenium
(Se)
enriched
organic
biomass.
However,
limited
information
exists
regarding
heterotrophic
tolerance
and
its
incorporation
into
Chlorella.
This
study
aimed
to
investigate
potential
using
vulgaris
K-01
for
biotransformation.
To
assess
dose-response
effect
Se
stress
on
strain,
time-series
growth
curves
were
recorded,
productivity
parameters
calculated,
Gaussian
process
(GP)
regression
analysis
was
performed.
The
strain’s
carbon
energy
metabolism
evaluated
by
measuring
residual
glucose
medium.
Characterization
different
forms
intracellular
medium
conducted
inductively
coupled
plasma-mass
spectrometry
(ICP-MS)
plasma
optical
emission
spectrometer
(ICP-OES).
EC50
value
strain
response
38.08
mg/L.
maximum
biomass
0.26
g/L/d.
GP
revealed
that
low-level
treatment
could
increase
accumulation
carrying
capacity
a
culture.
154.00
μg/g
DW.
These
findings
lay
groundwork
understanding
microalgal
Se-containing
nutraceuticals,
offering
valuable
insights
tolerance,
dynamics,
metabolic
responses
K-01.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 11, 2025
This
study
aims
to
investigate
the
association
between
serum
copper
(Cu),
selenium
(Se),
zinc
(Zn),
Se/Cu
and
Zn/Cu
ratios
risk
of
sarcopenia.
In
this
study,
which
involved
2766
adults
aged
≥
20
years
enrolled
in
National
Health
Nutrition
Examination
Survey
(NHANES)
from
2011
2016,
multivariable
logistic
regression,
restricted
cubic
spline
(RCS)
models
mediation
analyses
were
used.
After
full
adjustment,
regression
revealed
that
higher
levels
correlated
with
an
increased
Conversely,
(OR
0.45,
95%
CI
0.23-0.89,
P
=
0.023)
0.49,
0.27-0.90,
0.024)
associated
a
decreased
The
RCS
curve
indicated
non-linear,
roughly
inverted
L-shaped
relationship
Cu
sarcopenia
(P
non-linear
<
0.001).
Additionally,
0.179)
0.786)
showed
negative
linear
associations
risk.
Furthermore,
white
blood
cell
(WBC)
count,
neutrophil
systemic
inflammation
index
(SII)
identified
as
significant
mediators
sarcopenia,
proportions
6.34%,
6.20%,
4.37%,
respectively
(all
0.05).
Therefore,
balancing
essential
trace
metals
is
crucial
for
maintaining
muscle
health.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(5), P. 896 - 896
Published: March 4, 2025
Chronic
kidney
disease
(CKD)
is
a
leading
condition
in
terms
of
prevalence
and
overall
health
impact.
With
the
increased
life
expectancy
CKD
population
improvement
medical
care,
controlling
musculoskeletal
complications
remains
tough
challenge.
Patients
with
are
prone
to
falls,
fractures
sarcopenia,
enhancing
risk
death.
A
multitude
mechanisms
contribute
fractures,
treatment
suboptimal;
therefore,
prevention
must
stand
out
as
key
step.
This
review
aims
provide
an
overview
most
relevant
data
regarding
impact
nutrition
on
bone
disorders
sarcopenia
CKD.
The
newest
studies
emphasize
that
plant
protein
intake
associated
lower
production
uremic
toxins,
serum
phosphorus
levels,
stronger
bones.
We
conclude
patients
should
adopt
specific
diets
tailored
presence
osteoporosis,
renal
osteodystrophy,
muscle
wasting.
Low-protein
or
plant-dominant
containing
adequate
amount
could
be
better
choices
for
predialysis
order
protect
their
bones
muscles,
whereas
dialysis
population,
higher
essential
prevent
osteoporosis
sarcopenia.
In
all
CKD,
focusing
antioxidant
food
strong
antiaging
benefit
through
ensuring
good
health.
Foods,
Journal Year:
2024,
Volume and Issue:
13(11), P. 1779 - 1779
Published: June 5, 2024
Minimizing
human
exposure
to
arsenic
(As)
and
ensuring
an
adequate
dietary
intake
of
selenium
(Se)
are
significant
issues
in
research
on
food
sources.
This
study
measured
the
content
As
Se
muscles,
gills,
liver,
gonads
fish
round
goby
(Neogobius
melanostomus)
assess
benefits
risks
associated
with
their
consumption.
was
achieved
by
using
reference
(DRI),
estimated
daily
(EDI),
target
hazard
quotient
(THQ),
carcinogenic
risk
(CR).
The
elements
were
analyzed
atomic
absorption
spectrometry.
mean
concentrations
(in
μg
kg−1
wet
weight)
25.1
161.4
muscle,
58.8
367.4
47.4
635.3
gonads,
16.4
228.5
respectively.
Arsenic
muscle
portion
accounted
for
up
0.5%
DRI,
while
constituted
approximately
30%
DRI.
EDI
values
below
oral
dose
(RfD).
THQ
much
permissible
levels
(THQ
<
1),
CR
at
least
within
limit
(CR
10−4).
With
regard
content,
muscles
can
be
deemed
safe
consumers.
They
may
also
a
valuable
source
diet.
However,
consumption
should
monitored
proper
these
elements.
Toxicology Research,
Journal Year:
2024,
Volume and Issue:
13(5)
Published: Sept. 2, 2024
Abstract
Background
The
tobacco
epidemic
signifies
a
major
public
health
threat.
Nicotine
(NIC),
active
constituent
in
tobacco,
impedes
male
fertility
and
semen
quality.
This
work
is
implemented
to
explore
the
potential
of
selenium
nanoparticles
(SeNPs)
newly
fabricated
SeNPs
@vitamin
C
(SeNPs@VITC)
nanocomposite
mitigating
testicular
toxicity
induced
by
NIC.
Materials
methods
six
groups
48
adult
Wistar
rats
were
designed
as
follows:
control
group
injected
intraperitoneally
with
normal
saline,
treated
orally
2
mg/kg
SeNPs,
SeNPs@VITC
nanocomposite,
NIC
1.25
mL/kg
NIC,
NIC+
received
plus
Treatments
administered
over
28-day
period.
Results
treatment
significantly
caused
poor
sperm
quality,
decreased
serum
testosterone,
increased
follicle-stimulating
hormone
(FSH),
luteinizing
(LH)
concentrations,
reduced
hemoglobin
levels,
leukocytosis,
disrupted
oxidant/antioxidant
balance,
disorganized
structure.
construction
novel
compared
alone,
demonstrated
more
potent
ameliorative
effect
on
NIC-induced
reproductive
rats.
count,
percentage
head
abnormalities,
lowered
both
FSH
LH
improved
response.
Conclusions
Both
alleviated
but
exhibited
superior
efficacy.
could
be
employed
advance
enhanced
therapeutic
strategies
for
addressing
infertility.
Bulletin of the National Research Centre/Bulletin of the National Research Center,
Journal Year:
2024,
Volume and Issue:
48(1)
Published: Oct. 8, 2024
Abstract
Background
Intracellular
hydroperoxides
are
harmful
reactive
oxygen
species
that
can
cause
damage.
Cells
depend
on
antioxidant
enzymes
such
as
glutathione
peroxidase
(GPx)
to
prevent
their
accumulation.
GPx
is
present
in
all
cell
compartments,
including
the
cytosol,
mitochondria,
and
peroxisomes.
This
article
will
a
rapid
reliable
method
for
measuring
activity,
which
has
been
rigorously
tested
proven
dependable.
Results
The
enzyme
samples
incubated
phosphate
buffer
containing
specific
concentrations
of
(GSH)
peroxide
then
suitable
time
react
before
Ellman's
reagent
(5,5′-dithiobis-(2-nitrobenzoic
acid)
(DTNB)
added.
method,
designed
ease
use,
effective
straightforward.
When
GSH
reacts
with
DTNB,
mixed
disulfides
(GS-S-DTNB)
formed,
where
thiol
group
replaces
one
nitrobenzoic
acid
moieties
DTNB.
release
nitro-2-thiobenzoate
anion
(TNB
−
)
creates
yellow
be
measured
spectrophotometrically
at
wavelength
412
nm.
intensity
color
directly
proportional
unreacted
concentration.
activity
was
linked
decreased
absorbance
TNB
anion,
providing
sensitive
relatively
detecting
groups
various
biological
samples.
Conclusion
study
utilized
Box–Behnken
design
(BBD)
apply
response
surface
modeling
(RSM)
determine
best
conditions
activity.
efficiency
new
protocol
validated
by
comparing
matched
using
Bland–Altman
plot
analysis
reference
methods.
just
accurate
one,
correlation
coefficient
0.9991.
Graphical
abstract
