
Molecules, Journal Year: 2024, Volume and Issue: 29(7), P. 1437 - 1437
Published: March 23, 2024
In the present work, synthesis of new ethacrynic acid (EA) derivatives containing nitrogen heterocyclic, urea, or thiourea moieties via efficient and practical synthetic procedures was reported. The synthesised compounds were screened for their anti-proliferative activity against two different cancer cell lines, namely, HL60 (promyelocytic leukaemia) HCT116 (human colon carcinoma). results in vitro tests reveal that 1–3, 10, 16(a–c), 17 exhibit potent line, with values percentage viability ranging from 20 to 35% at 1 μM drug IC50 between 2.37 0.86 μM. Compounds 2 10 showed a very interesting 28 48% μM, respectively, HCT116. Two PyTAP-based fluorescent EA analogues also tested, showing good activity. A test on drug-likeness properties silico all synthetised performed order understand mechanism action most active compounds. molecular docking study conducted human proteins, glutathione S-transferase P1-1 (pdb:2GSS) caspase-3 (pdb:4AU8) as target enzymes. show 3 significant binding modes these This finding provides potential strategy towards developing anticancer agents, newly designed drug-like properties.
Language: Английский