Pharmacokinetics and Pharmacological/Bioactive Studies of Oridonin Derivatives in Anti-tumor Research DOI Creative Commons

Yao Sang

Transactions on Materials Biotechnology and Life Sciences, Journal Year: 2024, Volume and Issue: 4, P. 167 - 177

Published: Aug. 29, 2024

Objective: it to investigate the pharmacokinetics of oridonin derivatives and their effects on tumor cell proliferation (Pro), invasion (Inv), apoptosis (Apo), aiming provide a theoretical basis for cancer treatment. Materials Methods: drug statistics (DAS) software was utilized analyze average blood concentration-time data collected, determining pharmacokinetic parameters. Human breast MCF-7 cells were used as experimental cells. Cells rolled into three groups: Group A (GA, 0 μM), B (GB, 2 C (GC, 4 μM) treated with 15 μL different concentrations derivative CYD0618. Cell Pro cytotoxicity evaluated using MTT assay, while Apo, Inv, migration (Mig), protein expression changes assessed flow cytometry, Transwell assays, Western blotting, respectively. Results: over time, concentration gradually declined, notably within 5 hours. Pharmacokinetic analysis revealed initial distribution half-life (t1/2α) approximately 2.104 hours, elimination (t1/2β) 69.303 area under curve (AUC) 41.637 mg/h/L, clearance rate (CL) 0.089 L/h/kg, apparent volume (V) 0.4 L/kg. GB GC exhibited greatly lower counts than GA (P<0.05), showing fewer relative (P<0.05). The Mig reduced in versus showed migrated Furthermore, Inv markedly demonstrating invasive Apo rates higher had Additionally, STAT3 p-STAT3 levels substantially Conclusion: can inhibit Pro, by suppressing phosphorylation promoting Apo.

Language: Английский

pH-responsive self-assembled nanoparticles for tumor-targeted drug delivery DOI

Henglai Sun,

Xinyu Li, Qian Liu

et al.

Journal of drug targeting, Journal Year: 2024, Volume and Issue: 32(6), P. 672 - 706

Published: April 29, 2024

Recent advances in the field of drug delivery have opened new avenues for development novel nanodrug systems (NDDS) cancer therapy. Self-assembled nanoparticles (SANPs) based on tumour microenvironment great advantages improving antitumor effect, and pH-responsive SANPs prepared by combination nanomaterials self-assembly technology can effectively improve efficacy reduce systemic toxicity drugs. In this review, we describe characteristics its driving force, mechanism NDDS, type. A series tumour-targeted are discussed, with an emphasis relation between structural features theranostic performance.

Language: Английский

Citations

9
Carrier-free nanoparticles—new strategy of improving druggability of natural products DOI Creative Commons

Youyun Yao,

Zhenghu Xu, Hang Ding

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 14, 2025

There are abundant natural products resources and extensive clinical use experience in China. However, the active components of generally have problems such as poor water solubility low bioavailability, which limit their druggability. Carrier-free nanoparticles, nanocrystals, self-assembled extracellular vesicles derived from both animal plant sources, great application potential improving safety efficacy drugs due to simple flexible preparation methods, high drug loading capacity delivery efficiency, well long half-life blood circulation. It has been widely used biomedical fields anti-tumor, anti-bacterial, anti-inflammatory anti-oxidation. Therefore, based on that clinic, this review focuses advantages carrier-free nanoparticles delivering compounds, order improve process vivo draggability.

Language: Английский

Citations

1
Enhanced physicochemical, rheological and antioxidant properties of highly succinylated succinoglycan exopolysaccharides obtained through succinic anhydride esterification reaction DOI
Kyung‐Ho Kim, Jaepil Jeong, Sohyun Park

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 298, P. 140007 - 140007

Published: Jan. 17, 2025

Language: Английский

Citations

0
Evolutionary research trends of polysaccharides from Polygonatum genus: A comprehensive review of its isolation, structure, health benefits, and applications DOI
Yanjun Yang, Yufei Yang, Weilin Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141566 - 141566

Published: Feb. 1, 2025

Language: Английский

Citations

0
Targeting regulation of lipid metabolism with polysaccharide of traditional Chinese medicine for the treatment of non-alcoholic fatty liver disease: A review DOI
Wei Liu, Meng Sun, Hao Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141660 - 141660

Published: March 1, 2025

Language: Английский

Citations

0
Recent advances in the role of polysaccharides in liver diseases: a review DOI Creative Commons
Junfeng Wang, Hanxiang Wang,

Xiawen Yang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 27, 2025

Liver diseases are a serious health problem worldwide, especially with sustained increase in the burden of it every year. However, drugs commonly used patients have limited efficacy and adverse reactions associated long-term use. Therefore, is urgent to find effective safe alternatives. Polysaccharides currently considered promising alternatives traditional because their extensive activity low toxicity. This review investigated studies on hepatoprotective polysaccharides over past 6 years, detailing effects, potential mechanisms, drug carrier applications. These findings suggest that prominent preventive therapeutic effects various liver such as drug-induced injury, alcoholic disease, hepatitis B, non-alcoholic fatty fibrosis, hepatocellular carcinoma. Its mechanism includes multiple aspects metabolic regulation, reduction oxidative stress inflammation, regulation gut microbiota. Furthermore, owing good physicochemical properties, been applied delivery systems for chemotherapy small molecule drugs. further research essential bioavailability, structure-activity relationship, more clinical evidence polysaccharides. Continued exploration will provide tremendous treatment diseases.

Language: Английский

Citations

0
Enhancing cancer therapy: advanced nanovehicle delivery systems for oridonin DOI Creative Commons

Yilin Su,

Lisha Liu,

Chongyang Lin

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 3, 2024

Oridonin (ORI), an ent-kaurane diterpenoid derived from Rabdosia rubescens (Hemsl.) H.Hara, serves as the primary bioactive component of this plant. It demonstrates a broad spectrum therapeutic activities, including moderate to potent anticancer properties, alongside anti-inflammatory, antibacterial, antifibrotic, immunomodulatory, and neuromodulatory effects, thus influencing diverse biological processes. However, its clinical potential is significantly constrained by poor aqueous solubility limited bioavailability. In alignment with approach developing drug candidates natural compounds, various strategies, such structural modification nanocarrier systems, have been employed address these challenges. This review provides overview ORI-based nano-delivery emphasizing their improve applicability oridonin in oncology. Although some progress has made advancing ORI research, it remains insufficient for implementation, necessitating further investigation.

Language: Английский

Citations

1
Active herbal ingredients and drug delivery design for tumor therapy: a review DOI
Jing Han,

Y. Shen,

Ruiying Cao

et al.

Chinese Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 22(12), P. 1134 - 1162

Published: Dec. 1, 2024

Language: Английский

Citations

1
Induction of apoptosis by oridonin in nonfunctioning pituitary adenoma cells DOI

Hui‐Tong Chen,

Xing‐Yi Yuan,

Zhong‐Yu Wang

et al.

Drug Development Research, Journal Year: 2024, Volume and Issue: 85(6)

Published: Aug. 26, 2024

Abstract Nonfunctioning pituitary adenoma (NFPA) is one of the major subtypes adenomas (PA) and its primary treatment surgical resection. However, normal surgery fails to remove lesions completely there remains in lack frontline treatment, so development new drugs for NFPA no doubt urgent. Oridonin (ORI) has been reported have antitumor effects on a variety tumors, but whether it could exhibit same effect requires be further investigated. The ORI pituitary‐derived folliculostellate cell line (PDFS) viability, colony formation, proliferation ability, migration, invasion were examined by Cell Counting Kit‐8, formation assay, 5‑Ethynyl‑2'‑deoxyuridine wound‐healing Transwell assay. differentially expressed genes control ORI‐treated groups screened transcriptome sequencing analysis analyzed Kyoto Encyclopedia Genes Genomes (KEGG) Gene Ontology (GO) enrichment. cycle was performed detect changes cycle. Annexin V‐fluorescein isothiocyanate/propidium iodide staining apoptosis cells. Western blot assay Bax, Bcl‐2, cleaved Caspase‐3 protein expression. inhibited PDFS viability significantly suppressed proliferation, invasion. GO KEGG results showed that associated with signaling pathways such as In addition, blocked cells G2/M phase induced can trigger disruption collaboratively cells, making promising effective agent therapy.

Language: Английский

Citations

0
Pharmacokinetics and Pharmacological/Bioactive Studies of Oridonin Derivatives in Anti-tumor Research DOI Creative Commons

Yao Sang

Transactions on Materials Biotechnology and Life Sciences, Journal Year: 2024, Volume and Issue: 4, P. 167 - 177

Published: Aug. 29, 2024

Objective: it to investigate the pharmacokinetics of oridonin derivatives and their effects on tumor cell proliferation (Pro), invasion (Inv), apoptosis (Apo), aiming provide a theoretical basis for cancer treatment. Materials Methods: drug statistics (DAS) software was utilized analyze average blood concentration-time data collected, determining pharmacokinetic parameters. Human breast MCF-7 cells were used as experimental cells. Cells rolled into three groups: Group A (GA, 0 μM), B (GB, 2 C (GC, 4 μM) treated with 15 μL different concentrations derivative CYD0618. Cell Pro cytotoxicity evaluated using MTT assay, while Apo, Inv, migration (Mig), protein expression changes assessed flow cytometry, Transwell assays, Western blotting, respectively. Results: over time, concentration gradually declined, notably within 5 hours. Pharmacokinetic analysis revealed initial distribution half-life (t1/2α) approximately 2.104 hours, elimination (t1/2β) 69.303 area under curve (AUC) 41.637 mg/h/L, clearance rate (CL) 0.089 L/h/kg, apparent volume (V) 0.4 L/kg. GB GC exhibited greatly lower counts than GA (P<0.05), showing fewer relative (P<0.05). The Mig reduced in versus showed migrated Furthermore, Inv markedly demonstrating invasive Apo rates higher had Additionally, STAT3 p-STAT3 levels substantially Conclusion: can inhibit Pro, by suppressing phosphorylation promoting Apo.

Language: Английский

Citations

0