Bridging the gap between theory and treatment: Transition metal complexes as successful candidates in medicine

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 531, P. 216477 - 216477

Published: Feb. 8, 2025

Language: Английский

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Metal-Based Drug–DNA Interactions and Analytical Determination Methods

Molecules, Journal Year: 2024, Volume and Issue: 29(18), P. 4361 - 4361

Published: Sept. 13, 2024

DNA structure has many potential places where endogenous compounds and xenobiotics can bind. Therefore, bind along the sites of nucleic acid with aim changing its structure, genetic message, and, implicitly, functions. Currently, there are several mechanisms known to be involved in binding. These covalent non-covalent interactions. The interaction or metal base coordination is an irreversible binding it represented by intra-/interstrand cross-link. generally a reversible intercalation between pairs, insertion, major and/or minor groove binding, electrostatic interactions sugar phosphate backbone. In present review, we focus on types DNA-metal complex (including some representative examples) presenting methods currently used study them.

Language: Английский

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Pincer-metal complexes possessing pyrrolidine: synthesis, structural characterization, and cytotoxicity

Journal of Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 1020, P. 123346 - 123346

Published: Aug. 26, 2024

Language: Английский

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Tridentate N-donor Schiff base metal Complexes: Synthesis, Characterization, computational Studies, and assessment of biomedical applications in cancer Therapy, Helicobacter pylori Eradication, and COVID-19 treatment

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: unknown, P. 113371 - 113371

Published: Oct. 1, 2024

Language: Английский

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