O-carboxymethyl chitosan in biomedicine: A review
Lingbin Chen,
No information about this author
Yandi Xie,
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Xiaohang Chen
No information about this author
et al.
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
275, P. 133465 - 133465
Published: June 28, 2024
Language: Английский
Medical Applications and Cellular Mechanisms of Action of Carboxymethyl Chitosan Hydrogels
Molecules,
Journal Year:
2024,
Volume and Issue:
29(18), P. 4360 - 4360
Published: Sept. 13, 2024
Carboxymethyl
chitosan
(CMCS)
hydrogels
have
been
investigated
in
biomedical
research
because
of
their
versatile
properties
that
make
them
suitable
for
various
medical
applications.
Key
are
especially
valuable
use
include
biocompatibility,
tailored
solid-like
mechanical
characteristics,
biodegradability,
antibacterial
activity,
moisture
retention,
and
pH
stimuli-sensitive
swelling.
These
features
offer
advantages
such
as
enhanced
healing,
promotion
granulation
tissue
formation,
facilitation
neutrophil
migration.
As
a
result,
CMCS
favorable
materials
applications
biopharmaceuticals,
drug
delivery
systems,
wound
engineering,
more.
Understanding
the
interactions
between
biological
with
focus
on
influence
cellular
behavior,
is
crucial
leveraging
versatility.
Because
constantly
growing
interest
its
derivative
applications,
present
review
aims
to
provide
updated
insights
into
potential
based
recent
findings.
Additionally,
we
comprehensively
elucidated
mechanisms
underlying
actions
these
settings.
In
summary,
this
paper
recapitulates
data
gathered
from
current
literature,
offering
perspectives
further
development
utilization
carboxymethyl
contexts.
Language: Английский
Protective Effects of Astaxanthin against Oxidative Stress: Attenuation of TNF-α-Induced Oxidative Damage in SW480 Cells and Azoxymethane/Dextran Sulfate Sodium-Induced Colitis-Associated Cancer in C57BL/6 Mice
Marine Drugs,
Journal Year:
2024,
Volume and Issue:
22(10), P. 469 - 469
Published: Oct. 12, 2024
In
this
study,
we
investigated
the
protective
effects
of
astaxanthin
(AST)
against
oxidative
stress
induced
by
combination
azoxymethane
(AOM)
and
dextran
sulfate
sodium
(DSS)
in
colitis-associated
cancer
(CAC)
TNF-α-induced
human
colorectal
cells
(SW480),
as
well
underlying
mechanism.
vitro
experiments
revealed
that
reduced
reactive
oxygen
species
(ROS)
generation
inhibited
expression
Phosphorylated
JNK
(P-JNK),
ERK
(P-ERK),
p65
(P-p65),
NF-κB
downstream
protein
cyclooxygenase-2
(COX-2).
vivo
showed
ameliorated
AOM/DSS-induced
weight
loss,
shortened
colon
length,
caused
histomorphological
changes.
addition,
suppressed
cellular
inflammation
modulating
MAPK
pathways
inhibiting
proinflammatory
cytokines
IL-6,
IL-1β,
TNF-α.
conclusion,
attenuates
CAC
through
its
antioxidant
effects.
Language: Английский
Antioxidant Therapy in Inflammatory Bowel Diseases: How Far Have We Come and How Close Are We?
Lylian Ellen Militão dos Santos Xavier,
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T. Reis,
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Amylly Sanuelly da Paz Martins
No information about this author
et al.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(11), P. 1369 - 1369
Published: Nov. 8, 2024
Inflammatory
bowel
diseases
(IBD)
pose
a
growing
public
health
challenge
with
unclear
etiology
and
limited
efficacy
of
traditional
pharmacological
treatments.
Alternative
therapies,
particularly
antioxidants,
have
gained
scientific
interest.
This
systematic
review
analyzed
studies
from
MEDLINE,
Cochrane,
Web
Science,
EMBASE,
Scopus
using
keywords
like
“Inflammatory
Bowel
Diseases”
“Antioxidants.”
Initially,
925
publications
were
identified,
after
applying
inclusion/exclusion
criteria—covering
July
2015
to
June
2024
murine
models
or
clinical
trials
in
humans
evaluating
natural
synthetic
substances
affecting
oxidative
stress
markers—368
articles
included.
comprised
344
animal
24
human
studies.
The
most
investigated
antioxidants
polyphenols
active
compounds
medicinal
plants
(n
=
242;
70.3%).
found
strong
link
between
inflammation
IBD,
especially
on
nuclear
factor
kappa
B
erythroid
2-related
2
pathways.
However,
it
remains
whether
occurs
first
IBD.
Lipid
peroxidation
was
the
studied
damage,
followed
by
DNA
damage.
Protein
damage
rarely
investigated.
relationship
gut
microbiota
examined
103
Human
markers
scarce,
reflecting
major
research
gap
IBD
treatment.
PROSPERO
registration:
CDR42022335357
CRD42022304540.
Language: Английский
Improved bioavailability of polydatin and its protective effect against cisplatin induced nephrotoxicity through self-assembled fucoidan and carboxymethyl chitosan delivery system
Yinghan Wang,
No information about this author
Pengyu Xue,
No information about this author
Liang Gao
No information about this author
et al.
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
287, P. 138577 - 138577
Published: Dec. 9, 2024
Language: Английский