Synthetic Strategies and Structure Activity Relationships (SAR) of Biologically Active Coumarin‐Based Hybrids

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(16)

Published: April 1, 2025

Abstract Coumarin (2‐benzopyrone), a secondary plant metabolite, is considered privileged scaffold in medicinal chemistry. and its derivatives have been demonstrated to exhibit various biological activities such as antiviral, antibacterial, anticancer, anti‐inflammatory, anticonvulsant, antioxidant, antidepressant, anti‐Alzheimer, antidiabetic. Because of wide spectrum activities, it has explored extensively which resulted the development many clinically useful drug molecules. Attempts made prepare coumarin by either substituting them with variety aromatic heterocyclic rings functionalities or preparing hybrids linked through an appropriate linker obtain develop potential therapeutic agents. The inclusion natural metabolites gained importance recent past enhance activity. moieties are easily synthesized chemical methods Knoevenagel reaction, Pechmann condensation, Kostanecki–Robinson coupling Claisen rearrangement, Michel addition Witting Reformatsky Perkin so on. current review provides overview classification coumarins, details approaches used for synthesis derivatives. introduced synthetic compounds discussed structure‐activity relationship (SAR) supported their 2D molecular docking studies interaction within receptors. SAR will support chemist directing novel diverse pharmacological properties.

Language: Английский

Phytochemistry and Biological Profile of the Chinese Endemic Herb Genus Notopterygium

Molecules, Journal Year: 2024, Volume and Issue: 29(14), P. 3252 - 3252

Published: July 9, 2024

, a plant genus belonging to the Apiaceae family, is utilized in traditional Chinese medicine for its medicinal properties. Specifically, roots and rhizomes of these plants are employed phytotherapy alleviate inflammatory conditions headaches. This review provides concise overview existing information regarding botanical description, phytochemistry, pharmacology, molecular mechanisms two

Language: Английский