Synthesis of Difuropyridines from Chitin‐Derived 3‐Acetamidofuran and their Application to Photocatalytic Reactions DOI Open Access
Haifeng Gan, Peipei Ma, Tao Yang

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Abstract Difuropyridines have been prepared from aldehydes and chitin‐derived 3‐acetamidofuran (3AF) under acid‐catalyzed conditions. were comprehensively synthesized for the first time. The difuropyridines can be applied to prepare fluorescent probe analogs or catalyze decarboxylative reactions as photocatalysts.

Language: Английский

Novel Hydrazide Hydrazone Derivatives as Antimicrobial Agents: Design, Synthesis, and Molecular Dynamics DOI Open Access
Fatimah Agili

Processes, Journal Year: 2024, Volume and Issue: 12(6), P. 1055 - 1055

Published: May 22, 2024

Ester 2 was produced by reacting thiourea derivative 1 with ethyl 2-chloro-3-oxobutanoate in MeOH containing piperidine. Hydrazide 3 the latter ester hydrazine hydrate EtOH at reflux. By hydrazide aromatic/heterocyclic aldehydes, twelve derivatives of hydrazone 5a–l were produced. Spectral measurements and elemental analysis verified molecular structure. Compounds 2, 5a, 5c, 5d, 5f had strong effects on all pathogenic bacterial strains according to an evaluation antimicrobial qualities synthetic compounds. With inhibitory zone diameters ranging from 16 20.4 mm, exhibited strongest activity. Additionally, minimum concentration (MIC) assessed. The best outcomes found hydrazones 5c 5f. For B. subtilis, MIC 2.5 mg/mL. E. coli K. pneumoniae, mechanics-generalized born surface area (MM/GBSA) utilized compute binding free energies via a dynamics simulation most active compounds, 5c. Moreover, computational analyses demonstrated that substantial affinity for site DNA gyrase B, suggesting this compound could be platform new structure-based design efforts.

Language: Английский

Citations

4
An insight into Synthetic, Structural and Medicinal perspective of imidazole analogs: A review DOI
Govind Yadav,

Ranjana Jain

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117524 - 117524

Published: March 1, 2025

Language: Английский

Citations

0
Identification of hydroxyphenyl cyanovinyl thiazoles as new structural scaffold of potential antibacterial agents DOI

Lu Xing,

Shaolin Zhang, Cheng‐He Zhou

et al.

Bioorganic & Medicinal Chemistry Letters, Journal Year: 2025, Volume and Issue: unknown, P. 130258 - 130258

Published: April 1, 2025

Language: Английский

Citations

0
Pharmaceutical perspectives of thiazole analogues: An overview DOI Creative Commons

Archana R. Patil,

Basappa C. Yallur, Sampath Chinnam

et al.

Results in Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 101820 - 101820

Published: Oct. 1, 2024

Language: Английский

Citations

3
One-pot, three-component synthesis and in vitro anti-bacterial evaluation of some novel chromeno[4,3-d]pyrimidine, thiazol-2H-chromens, and thiadiazol-2H-chromen derivatives DOI
Behjat Pouramiri, Maryam Sharifi,

Fatemeh Riyahi Zaniani

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141658 - 141658

Published: Feb. 1, 2025

Language: Английский

Citations

0
Synthesis and Crystal Structural Analysis of bismuth phosphovanadate compounds: An Eco-Friendly and Recyclable Catalyst for Green Synthesis of Imidazole Derivatives DOI

Soumya Ferraa,

Youssef Merroun,

Hanane Barebita

et al.

Journal of the Indian Chemical Society, Journal Year: 2024, Volume and Issue: 101(10), P. 101313 - 101313

Published: Aug. 18, 2024

Language: Английский

Citations

0
Green One-Pot Synthesis of Thiazole Scaffolds Catalyzed by Reusable NiFe2O4 Nanoparticles: In Silico Binding Affinity and In Vitro Anticancer Activity Studies DOI Creative Commons

Satish Gudala,

Archi Sharma,

Aruna Lankada

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(36), P. 38262 - 38271

Published: Aug. 29, 2024

A facile, green, one-pot multicomponent synthesis strategy was employed to fabricate novel thiazole scaffolds incorporating phthalazine, pyridazine, and pyrido-pyridazine derivatives (4a–4o). This synthetic route entailed the reaction of an α-halo carbonyl compound (1) with thiosemicarbazide (2) various anhydrides (3a–3o), utilizing NiFe2O4 nanoparticles as a reusable catalyst in ethanol:water (1:1) solvent system. The cytotoxicity synthesized compounds meticulously assessed against three cancer cell lines, A375, HeLa, MCF-7, employing IC50 values (μM) benchmark, compared reference drug erlotinib. Compound 4n displayed remarkable efficacy A375 (0.87 ± 0.31 μM), HeLa (1.38 1.24 MCF-7 (1.13 0.96 μM) significantly surpassing erlotinib's values. Additionally, 4k, 4l, 4m, 4o demonstrated notable across all tested indicating their potential effective anticancer agents. In silico docking studies Hsp82 Hsp90 proteins indicated that ligands 4c, 4j, 4o, 4l had superior binding affinities ADME analysis showed 4n, favorable pharmacokinetic profiles, including nontoxicity, high human intestinal absorption, low CYP inhibitory promiscuity. Structure–activity relationship revealed cyano benzylidene substitutions enhanced activity. Overall, compounds, particularly efficacy, interactions, promising making them strong candidates for further development

Language: Английский

Citations

0
Synthesis of Difuropyridines from Chitin‐Derived 3‐Acetamidofuran and their Application to Photocatalytic Reactions DOI Open Access
Haifeng Gan, Peipei Ma, Tao Yang

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Abstract Difuropyridines have been prepared from aldehydes and chitin‐derived 3‐acetamidofuran (3AF) under acid‐catalyzed conditions. were comprehensively synthesized for the first time. The difuropyridines can be applied to prepare fluorescent probe analogs or catalyze decarboxylative reactions as photocatalysts.

Language: Английский

Citations

0