Nephroprotective effects of substances of medicine food homology and traditional Chinese medicine phytochemicals against acute kidney injury

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 19, 2025

Acute kidney injury (AKI) represents significant medical challenges due to its elevated rates of morbidity and mortality, with limited therapeutic options currently available. Hence, the exploration novel medicinal treatments for AKI management remains vital. Substances medicine food homology (SMFH), referring substances having characteristics both medicine, have been applied in China thousands years.They could be used daily diets body conditioning. Traditional Chinese (TCM), naturally derived components demonstrated effectiveness, presents distinctive benefits treatment. Numerous studies shown that SMFH TCM phytochemicals function satisfactorily nephroprotective effects a effect on alleviating as well complications. In this review, pathogenesis was illustrated. We concentrated against tried summarize underlying mechanisms various kinds AKI, highlighting crucial phytochemical prevention therapy. Besides, strategies globalization are analysed. This review comprehensively reveals exhibit promising potential intervention by targeting signal pathways targets, which would contribute AKI's cognition, preventive treatments, global promotion.

Language: Английский

The Effects of Polyphenols on Doxorubicin‐Induced Nephrotoxicity by Modulating Inflammatory Cytokines, Apoptosis, Oxidative Stress, and Oxidative DNA Damage

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

ABSTRACT Doxorubicin (DOX) is an anthracyclic antibiotic with anti‐neoplastic activity that has been found to be a highly effective and commonly used chemotherapeutic agent in the treatment of variety solid hematologic malignancies. However, its effectiveness limited by occurrence dose‐related renal, myocardial, bone marrow toxicities. The clinical use DOX associated nephrotic syndrome characterized heavy proteinuria, hypoalbuminemia, hyperlipidemia. DOX‐induced changes renal tissue rats include increased glomerular capillary permeability tubular atrophy. Several lines evidence suggest reactive oxygen species oxidative stress have damage. mechanism nephrotoxicity believed mediated through free radical formation, iron‐dependent damage biological macromolecules, membrane lipid peroxidation. Polyphenols are present high concentration fruits vegetables. They shown potent antioxidant cytoprotective effects preventing endothelial apoptosis caused oxidants. Treatment polyphenols prevent liver suppress overexpression inducible nitric oxide synthase, which induced various inflammatory stimuli. In addition, epidemiological studies suggested intake may reduced risk modulating cytokines, apoptosis, stress, DNA Therefore, review, we examined influence on nephrotoxicity.

Language: Английский

Mechanisms of ferroptotic and non-ferroptotic organ toxicity of chemotherapy: protective and therapeutic effects of ginger, 6-gingerol and zingerone in preclinical studies

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Abstract Chemotherapy (CT) is one of the flagship options for treatment cancers worldwide. It involves use cytotoxic anticancer agents to kill or inhibit proliferation cancer cells. However, despite its clinical efficacy, CT triggers side effect toxicities in several organs, which may impact patient’s quality life and outcomes. While toxicity consistent with non-ferroptotic mechanisms involving oxidative stress, inflammation, mitochondrial impairment other aberrant signalling leading apoptosis necroptosis, recent studies show that ferroptosis, a non-apoptotic, iron-dependent cell death pathway, also involved pathophysiology organ toxicity. provokes ferroptosis via system Xc – /GPX-4/GSH/SLC7A11 axis depletion, ferritinophagy, iron overload, lipid peroxidation upregulation ferritin-related proteins. Cisplatin (CP) doxorubicin (DOX) are common drugs indicated induce vitro vivo. Studies have explored natural preventive therapeutic strategies using ginger rhizome major bioactive compounds, 6-gingerol (6G) zingerone (ZG), combat Ginger extract, 6G ZG mitigate dysfunction toxicity, but their effects on CT-induced remain unclear. Systematic investigations are, therefore, needed unfold roles ginger, as they potential prevention This review reveals ferroptotic protective against CT-induced, toxicities.

Language: Английский