Boosting the human antiviral response in conjunction with natural plant products
Frontiers in Natural Products,
Journal Year:
2025,
Volume and Issue:
3
Published: Jan. 7, 2025
The
increasing
prevalence
of
viral
infections
and
the
emergence
drug-resistant
or
mutant
strains
necessitate
exploration
novel
antiviral
strategies.
Accumulating
evidence
suggests
that
natural
plant
products
have
significant
potential
to
enhance
human
response.
Various
(PNPs)
known
for
their
properties
been
evaluated
ability
modulate
immune
responses
inhibit
infections.
Research
has
focused
on
understanding
mechanisms
by
which
these
PNPs
interact
with
system
complement
existing
therapies.
control
compounds
such
as
alkaloids,
flavonoids,
terpenoids,
polyphenols
promote
cytokine
synthesis,
increase
T-cell
macrophage
activity,
activate
genes.
Studies
investigated
molecular
interactions
between
PNPs,
viruses,
host
cells,
exploring
combining
conventional
drugs
efficacy.
However,
several
challenges
remain,
including
identifying,
characterizing,
standardizing
PNP
extracts,
optimizing
dosages,
improving
bioavailability,
assessing
long-term
safety,
navigating
regulatory
approval.
promising
is
being
explored
develop
new,
effective,
This
review
outlines
a
framework
an
integrative
approach
connect
full
in
combating
health.
By
treatments,
more
effective
sustainable
management
diseases
can
be
achieved.
Language: Английский
Syzygium aromaticum Bud Extracted Core–Shell Ag–Fe Bimetallic Nanoparticles: Phytotoxic, Antioxidant, Insecticidal, and Antibacterial Properties
Crystals,
Journal Year:
2024,
Volume and Issue:
14(6), P. 510 - 510
Published: May 27, 2024
Today,
there
is
the
roar
of
sustainable
material
development
around
globe.
Green
nanotechnology
one
extensions
sustainability.
Due
to
its
approach,
green
fabrication
nanoparticles
has
recently
surpassed
their
classical
synthesis
in
popularity.
Among
metal
nanoparticles,
contemporary
findings
have
demonstrated
that
bimetallic
possess
more
potential
for
different
applications
than
monometallic
due
synergistic
effects
two
metals.
So,
we
are
presenting
facile,
one-vessel,
and
one-step
phyto-fabrication
Ag–Fe
BMNPs
using
bud
extract
Syzygiumaromaticum.
The
synthesized
were
characterized
by
UV-VIS,
XRD,
EDX,
FTIR,
SEM.
NPs
underwent
biological
studies.
radical
scavenging
was
found
be
64%
73%,
insecticidal
80%
100%,
respectively.
Similarly,
both
exhibited
good
antibacterial
activity.
zone
inhibition
100
mg/mL
1
cm
against
all
bacterial
species,
i.e.,
K.
pneumonia,
E.
coli,
S.
aureus.
It
1.5
cm,
1.3
aureus,
respectively,
showing
activity
higher
NPs.
this
study
unlocks
eco-safe,
cost-effective,
least-harmful
methodology
with
SA
medical
agricultural
fields,
a
step
towards
Language: Английский
Immunomodulatory effect of allium sativum in type 2 diabetes mellitus
World Journal of Experimental Medicine,
Journal Year:
2025,
Volume and Issue:
15(2)
Published: April 11, 2025
Type
2
diabetes
mellitus
(T2DM)
is
a
metabolic
disorder
marked
by
chronic
hyperglycemia
and
low-grade
inflammation,
contributing
to
various
complications.
Natural
agents
with
immunomodulatory
antioxidant
properties
have
gained
attention
as
adjunct
therapies.
To
review
the
effects
of
Allium
sativum
on
inflammatory
pathways
alterations
associated
T2DM.
A
narrative
was
performed
using
PubMed/MEDLINE,
EMBASE,
Scielo
databases.
The
search
included
terms
such
“allium
sativum”,
“inflammation",
“oxidative
stress”,
“diabetes
mellitus”.
Studies
in
English
Spanish
-
ranging
from
clinical
trials
meta-analyses
were
selected
based
relevance.
Bioactive
compounds
allicin,
S-allyl
cysteine,
diallyl
disulfide
exhibit
anti-inflammatory,
antioxidant,
hypoglycemic,
lipid-lowering
actions.
Preclinical
studies
show
improved
glucose
metabolism,
insulin
sensitivity,
organ
function.
Moreover,
evidence
supports
reductions
fasting
glucose,
hemoglobin
A1c,
blood
pressure,
oxidative
stress,
good
safety
profiles.
appears
be
promising
adjuvant
T2DM
management,
offering
anti-inflammatory
benefits.
Nonetheless,
further
high-quality
are
needed
confirm
its
long-term
efficacy
standardize
therapeutic
use.
Language: Английский
Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals
International Journal of Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
unknown, P. 125135 - 125135
Published: Dec. 1, 2024
Language: Английский
Immune-stimulating and antioxidant properties of a traditional Algerian plant combination: Date fruit (Phoenix dactylifera) and Fenugreek seeds (Trigonella foenum-graecum)
The North African Journal of Food and Nutrition Research,
Journal Year:
2024,
Volume and Issue:
8(18), P. 253 - 261
Published: Dec. 5, 2024
Background:
Combinatory
therapy
involving
medicinal
plants
utilizes
blends
of
different
species
to
enhance
therapeutic
efficacy,
increase
potency,
and
minimize
adverse
effects.
This
approach
leverages
the
synergistic
interactions
plant-derived
bioactive
compounds,
offering
a
natural
holistic
strategy
for
addressing
various
health
conditions.
Aims:
study
aimed
evaluate
effects
traditional
Algerian
combination
date
fruit
(Phoenix
dactylifera)
fenugreek
seeds
(Trigonella
foenum-graecum)
on
phagocytic
activity
hepatic
glutathione
(GSH)
levels.
Materials
Methods:
Phagocytic
was
measured
using
carbon
clearance
rate
test,
while
levels
were
determined
spectrophotometrically
from
liver
homogenates.
Results:
The
results
demonstrated
that
both
GSH
significantly
enhanced
in
animals
treated
with
plant
(p
<
0.001).
faster
mice
receiving
combined
treatment
(FG
“Fenugreek”
/
PD
“Phoenix
dactylifera”:
14.66
±
4.143)
compared
NaCl
control
group
(49.77
16.98).
Additionally,
index
higher
FG
(7.128
0.823)
groups
either
alone
(FG:
4.082
0.306)
or
(PD:
4.87
0.608).
Hepatic
also
elevated
other
=
0.040).
Conclusions:
exhibits
synergic
effect,
enhancing
immune
system
antioxidant
capacity.
These
findings
suggest
its
potential
development
novel,
naturally
derived
agents.
Keywords:
activity,
fruit,
seeds,
GSH,
therapy.
Language: Английский