Recent Developments in the Metal-Catalyzed Synthesis of Nitrogenous Heterocyclic Compounds

Molecules, Journal Year: 2024, Volume and Issue: 29(22), P. 5458 - 5458

Published: Nov. 19, 2024

Metal-catalyzed cyclization reactions have become a powerful and efficient approach for the stereoselective construction of both carbocyclic heterocyclic ring systems. Transition metal complexes, with their ability to activate selectively functionalize organic substrates, revolutionized various areas synthetic chemistry. This review highlights recent advancements in metal-catalyzed reactions, especially synthesis nitrogen-containing heterocycles like imidazoles, pyridines, pyrimidines, indoles. These significantly impacted fields such as natural product synthesis, pharmaceuticals, functional materials, electronics. Novel catalytic systems, ligand designs, reaction conditions continue expand capabilities these driving further progress made provides comprehensive overview research.

Language: Английский

β,β-Difluoro Peroxides as Fluorinated C2-Building Blocks for the Construction of Functionalized Indolizines

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 5927 - 5927

Published: Dec. 16, 2024

An effective method for the construction of functionalized indolizines has been developed in which β,β-difluoro peroxides act as novel C2-building blocks to implement [3+2] annulation with pyridinium ylides under base-mediated conditions. With this protocol, a broad range multisubstituted were prepared moderate good yields mild conditions, and many useful functional groups tolerated.

Language: Английский