The antitumor mechanisms of glabridin and drug delivery strategies for enhancing its bioavailability DOI Creative Commons
Chong Li, Yu Tian Wang, Wenjing Zhang

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Dec. 11, 2024

Glabridin, a flavonoid derived from the plant

Language: Английский

Yanghe decoction inhibits inflammation-induced lung metastasis of colorectal cancer DOI

Lu Zhang,

Songyu Liu, Kai Ding

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 340, P. 119257 - 119257

Published: Dec. 16, 2024

Language: Английский

Citations

10
Enhancing NK Cell Antitumor Activity With Natural Compounds: Research Advances and Molecular Mechanisms DOI Open Access

Yu Wu,

Mingxiao Yin,

Wenjiao Xia

et al.

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

In recent years, immunotherapy has become a novel antitumor strategy in addition to traditional surgery, radiotherapy, and chemotherapy exhibited promising results clinical applications. Despite significant breakthroughs immunotherapy, such as immune checkpoint blockade CAR-T cell therapy, it remains necessary develop more efficacious, safer, cheaper immunotherapeutic drugs due factors including small reaction populations, acquired resistance, adverse side effects, high costs. Natural killer (NK) cells are preeminent cytotoxic lymphocytes of the innate system that act first line defense against tumors synergistically enhance adaptive response T lymphocytes. Therefore, boosting function NK is an important direction development immunotherapy. For decades, various immunotherapies adoptive antibody drugs, cytokines supplement, chemical immunomodulators have been developing rapidly improve cells. Compared biological derived from natural products outstanding advantages low immunogenicity, multi-targeting, cost-effectiveness. Currently, increasing attention being focused on discovering cell-stimulating agents products, polysaccharides, alkaloids, terpenoids, saponins, phenolics, quinones. This review aims categorize summarize comprehensive research progress these discuss their potential molecular mechanisms regulating cells, explore applications standalone treatments or combination with conventional regimens.

Language: Английский

Citations

1
Microenvironment-based immunotherapy in oral cancer: a comprehensive review DOI

Hassan Mivehchi,

Aisan Eskandari-Yaghbastlo,

Masumeh Ghazanfarpour

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(5)

Published: March 28, 2025

Language: Английский

Citations

1
Enhancing Gastrointеstinal (GI) Cancer Therapies with Ganoderma Lucidum: A Review of Mechanisms and Efficacy DOI Creative Commons
Kaushal Kishor Sharma, Saksham Gupta, Prakash S. Bisen

et al.

Published: Jan. 1, 2025

Gastrointestinal (GI) cancer stands as a global health challenge, necessitating effective therapeutic approaches with minimal adverse еffеct. This review delves into the potential of Ganoderma lucidum, macro fungus, commonly recognized for its medicinal properties, in traditional Chinese medicine. Macro fungus acts promising adjunct treating gastrointestinal cancer. The bioactive compounds from lucidum are polysaccharides, triterpenes, and proteins demonstrating anti-tumor activities by modulating key cellular mechanisms such proliferation, apoptosis, metastasis, autophagy. elucidates underpinning G. lucidum's anti-GI properties through an extensive exploration available literature. Furthermore, it provides understanding clinical applications shedding light on complementary option realm both western comprehensive analysis presented herein aims to serve valuable guide future studies endeavors, fostering dееpеr lucidum’s role preventing GI

Language: Английский

Citations

0
A review on polysaccharide-based tumor targeted drug nanodelivery systems DOI
Liangxing Tu,

Banghuai Xing,

Shenglin Ma

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140820 - 140820

Published: Feb. 1, 2025

Language: Английский

Citations

0
Polysaccharides from traditional Chinese medicine and their nano-formulated delivery systems for cancer immunotherapy DOI

Linlin Sun,

Yuting Liu, Qihui Sun

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 357, P. 123416 - 123416

Published: Feb. 20, 2025

Language: Английский

Citations

0
Natural Alkaloids Modulating Macrophage Polarization: Innovative Therapeutic Strategies for Inflammatory, Cardiovascular, and Cancerous Diseases DOI
Jing Lü, Minghao Yin, Yixuan Song

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156709 - 156709

Published: April 1, 2025

Language: Английский

Citations

0
Tumor microenvironment and cancer metastasis: molecular mechanisms and therapeutic implications DOI Creative Commons
Çıgır Biray Avci, Bakiye Göker Bağca, Masoud Nikanfar

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 12, 2024

The tumor microenvironment (TME) plays a crucial role in cancer development and metastasis. This review summarizes the current research on how TME promotes metastasis through molecular pathways, focusing key components, such as cancer-associated fibroblasts, immune cells, endothelial cytokines, extracellular matrix. Significant findings have highlighted that alterations cellular communication within enable cells to evade surveillance, survive, invade other tissues. highlights roles of TGF-β VEGF signaling promoting angiogenesis matrix remodeling, which facilitate Additionally, we explored metabolic reprogramming stromal influenced by nutrient availability TME, drives progression. study also evaluated therapeutic strategies targeting these interactions disrupt By providing multidisciplinary perspective, this suggests understanding basis can lead more effective therapies identify potential avenues for future research. Future should prioritize unraveling complex environment, could novel personalized treatments. Moreover, advancements technologies single-cell analysis, spatial transcriptomics, epigenetic profiling offer promising identifying new targets improving efficacy immunotherapies, particularly context

Language: Английский

Citations

3
Exploring the anti-lung cancer mechanism of Ganoderma lucidum and its relationship with the level of immune cell infiltration based on network pharmacology and molecular docking DOI Creative Commons
Yuanyuan Luo,

Xue-Hua Luo,

Zhijian Xue

et al.

ONCOLOGIE, Journal Year: 2024, Volume and Issue: 26(5), P. 831 - 843

Published: Aug. 9, 2024

Abstract Objectives Ganoderma lucidum has anti-tumor effects, but its mechanism of action against lung cancer is not clear. This study aims to use molecular docking and network pharmacology investigate how G. inhibits tumor growth in this relationship relates the degree immune cell infiltration. Methods By utilizing TCMSP database, therapeutic targets active ingredients were discovered. Based on found subsequent rounds screening, a protein interaction (PPI) was constructed. Additionally, enrichment analysis conducted using GO KEGG. The with help AutoDock Tools PyMOL. Finally, we investigated relationships between cells commonalities and. Results primary ’s anti-lung activities, according studies, are ADRB2, OPRM1, SLC6A4, JUN. components fighter Ergosterol ganoderal B, ganolucidic acid E, beta-sitosterol. revealed that beta-sitosterol had highest stability infiltration indicated potential correlation biomarkers associated treatment for infiltrating cells. Conclusions combats by targeting multiple signaling pathways, facilitating apoptosis interacting responses. elucidates avenues future research into mechanisms therapy.

Language: Английский

Citations

1
The antitumor mechanisms of glabridin and drug delivery strategies for enhancing its bioavailability DOI Creative Commons
Chong Li, Yu Tian Wang, Wenjing Zhang

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Dec. 11, 2024

Glabridin, a flavonoid derived from the plant

Language: Английский

Citations

0