Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

With growing recognition of the pivotal role gut microbiota in human health, probiotics have gained widespread attention for their potential to restore microbial homeostasis. However, a critical challenge persists: limited colonization efficiency among most probiotic strains compromises therapeutic efficacy. This overview synthesizes ecological principles with cutting-edge microbiome research elucidate dynamic interplay between dietary components and within intestinal niche. systematically analyzes: (1) stage-specific mechanisms spanning introduction, establishment, proliferation; (2) nutrient-driven modulation composition function; (3) dual common patterns as both facilitators disruptors persistence. Notably, this identifies key strategies, including precision delivery prebiotic fibers polyphenol-microbiota crosstalk, that enhance niche adaptation through pH optimization, adhesion potentiation, competitive exclusion pathogens. Furthermore, critically evaluates current limitations research, particularly strain-specific variability methodological constraints simulating host-microbe-diet tripartite interactions. To bridge these gaps, proposes an interdisciplinary framework integrating omics-driven strain selection, engineered systems, personalized nutrition models. Collectively, work advances mechanistic understanding diet-microbiota interactions while providing actionable insights developing targeted therapies evidence-based interventions optimize ecosystem resilience.

Language: Английский