Optimization of the suspension procedure by Box-Behnken design for the determination of manganese, iron, and zinc in zeolite clinoptilolite with the TXRF system and insight into its antioxidant properties DOI Creative Commons
Jasna Jablan,

Maja Bival Štefan,

Dario Paler

et al.

Acta Pharmaceutica, Journal Year: 2024, Volume and Issue: 74(4), P. 655 - 672

Published: Dec. 1, 2024

Abstract Zeolites are a large family of minerals and the most studied is naturally occurring clinoptilolite. They possess anti-inflammatory, antioxidant, detoxifying properties which makes them valuable for medicinal use. Element analysis zeolite’s composition necessary its precise chemical characterization, within this work development suspension method determination manga nese, iron, zinc by total reflection X-ray fluorescence spec-trometry (TXRF) was presented. The Box-Behnken design based on response surface methodology applied to determine optimal sample preparation conditions. significant variables such as amount, volume deposition, dispersant were selected critical variables. Based results obtained, suspensions prepared weighing 10 mg adding 1 mL 5 % Triton X-100 with Ga internal standard deposition set at mL. obtained TXRF comparable those FAAS method, indicating that technique can be used instead conventional methods. Using best analytical conditions, limits detection trace elements in range 0.2–0.6 kg –1 . Trueness precision results, evaluated CRM analysis, cases acceptable recoveries values 104.9–111.4 relative deviations 2–10 (. = 6). showed no ability quench free radicals nor influence dietary antioxidants.

Language: Английский

Targeting Ferroptosis/Nrf2 Pathway Ameliorates AlCl3-Induced Alzheimer’s Disease in Rats: Neuroprotective Effect of Morin Hydrate, Zeolite Clinoptilolite, and Physical Plus Mental Activities DOI Open Access
Karema Abu-Elfotuh,

Yasmin Mahran,

Walaa Bayoumie El Gazzar

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1260 - 1260

Published: Jan. 31, 2025

Alzheimer’s disease (AD) is a significant health challenge in the 21st century. In spite of approval many new disease-modifying therapies for AD, clinical advantages these treatments are less certain. Aim: This investigation was intended to determine potential neuroprotective impact morin hydrate (MH), zeolite clinoptilolite (ZC), and/or physical and mental activities (PhM) on an aluminum chloride (AlCl3)-induced AD rat model. Methods: Male Sprague Dawley rats were randomly allocated into seven groups. Group I control group. Groups II–VII treated with AlCl3 5 weeks. III–VII tested effects MH, ZC, PhM. Biochemical, brain histopathological, behavioral studies performed. Results: PhM, ZC combined therapy exhibited effect demonstrated by corrected catecholamines tau β-amyloid levels, as well antioxidant anti-ferroptotic probably through Nrf2/HO-1/GPX4 ACSL4 signaling pathways. addition, counteracted inflammatory responses modulating TLR4/NF-κβ/NLRP3 inflammasome expression. Moreover, groups showed maximum improvement both APOE4/LRP1 Wnt3/β-catenin/GSK-3β expressions. Conclusion: research highlights MH plus PhM against AlCl3-induced via modulation Nrf2/HO-1/GPX4, TLR4/NF-κβ/NLRP3, APOE4/LRP1, It first point out inclusion ferroptosis-Nrf2/inflammasomes cross-talk neuroprotection mechanism MH/ZC AlCl3-mediated

Language: Английский

Citations

0
Lactoferrin/lactoferrin receptor: Neurodegenerative or neuroprotective in Parkinson’s disease? DOI
Zhong‐Ming Qian, Wei Li,

Qian Guo

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102474 - 102474

Published: Aug. 27, 2024

Language: Английский

Citations

3
Optimization of the suspension procedure by Box-Behnken design for the determination of manganese, iron, and zinc in zeolite clinoptilolite with the TXRF system and insight into its antioxidant properties DOI Creative Commons
Jasna Jablan,

Maja Bival Štefan,

Dario Paler

et al.

Acta Pharmaceutica, Journal Year: 2024, Volume and Issue: 74(4), P. 655 - 672

Published: Dec. 1, 2024

Abstract Zeolites are a large family of minerals and the most studied is naturally occurring clinoptilolite. They possess anti-inflammatory, antioxidant, detoxifying properties which makes them valuable for medicinal use. Element analysis zeolite’s composition necessary its precise chemical characterization, within this work development suspension method determination manga nese, iron, zinc by total reflection X-ray fluorescence spec-trometry (TXRF) was presented. The Box-Behnken design based on response surface methodology applied to determine optimal sample preparation conditions. significant variables such as amount, volume deposition, dispersant were selected critical variables. Based results obtained, suspensions prepared weighing 10 mg adding 1 mL 5 % Triton X-100 with Ga internal standard deposition set at mL. obtained TXRF comparable those FAAS method, indicating that technique can be used instead conventional methods. Using best analytical conditions, limits detection trace elements in range 0.2–0.6 kg –1 . Trueness precision results, evaluated CRM analysis, cases acceptable recoveries values 104.9–111.4 relative deviations 2–10 (. = 6). showed no ability quench free radicals nor influence dietary antioxidants.

Language: Английский

Citations

0