Published: Jan. 1, 2025
Language: Английский
Published: Jan. 1, 2025
Language: Английский
Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: unknown, P. 113806 - 113806
Published: Dec. 1, 2024
Language: Английский
Citations
5Biomaterials Advances, Journal Year: 2025, Volume and Issue: 172, P. 214246 - 214246
Published: Feb. 27, 2025
Language: Английский
Citations
0Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13
Published: March 20, 2025
Zinc oxide nanoparticles (ZnO-NPs) have gained significant attention in cancer therapy due to their unique physical and chemical properties, particularly treating gastrointestinal (GI) cancers such as gastric, colorectal, hepatocellular carcinoma. These generate reactive oxygen species (ROS) upon entering cells, causing oxidative stress that leads cellular damage, DNA fragmentation, apoptosis. ZnO-NPs affect the expression of key proteins involved apoptosis, including p53, Bax, Bcl-2, which regulate cell cycle arrest programmed death. Additionally, can reduce mitochondrial membrane potential, further enhancing apoptosis cells. Furthermore, inhibit proliferation by interfering with progression. They levels cyclins cyclin-dependent kinases (CDKs), leading arrest. also exhibit anti-metastatic properties inhibiting migration invasion cells through modulation signaling pathways adhesion cytoskeletal dynamics. The efficacy overcoming chemotherapy resistance has been demonstrated ability IC50 values chemotherapeutic agents, making more susceptible drug-induced In this review, we summarize mechanisms exert anticancer effects GI cancers, focusing on regulation, metastasis inhibition, while highlighting current limitations translating these findings into effective clinical treatments.
Language: Английский
Citations
0Journal of Sol-Gel Science and Technology, Journal Year: 2025, Volume and Issue: unknown
Published: April 3, 2025
Language: Английский
Citations
0Published: Jan. 1, 2025
Language: Английский
Citations
0