Anxiolytic, Antidepressant, and Anticholinesterase Effects of Essential Oil from Myrcia sylvatica (G.Mey.) DC

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 110 - 110

Published: Jan. 12, 2025

Aromatic plants are rich sources of essential oils (EOs), recognized for their therapeutic properties due to diversity phytochemicals. This study investigated the anxiolytic and antidepressant effects Myrcia sylvatica oil (MsEO) through inhalation in an animal model its vitro anticholinesterase (AChE) activity. The EO was obtained by hydrodistillation, volatile constituents were analyzed GC-MS. Swiss mice exposed doses 0.1%, 1%, 2% via apparatus. activity assessed using elevated plus maze light-dark box tests, while evaluated tail suspension forced swimming tests. To examine potential side effects, animals subjected rotarod, Y-maze, Morris water tests assess motor coordination, memory, learning. Anticholinesterase determined direct bioautography colorimetry based on Ellman method. results demonstrated that MsEO at 0.1% 1% significantly reduced anxiety depressive-like behaviors without impairing learning, or coordination animals. Moreover, inhibited acetylcholinesterase with IC50 0.47 μg/mL. These findings suggest has applications depression disorders, additional warranting further investigation cognitive-related conditions.

Language: Английский

Exploring plant-based resources: A frontier in combating against common bacterial and fungal pathogens

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 303 - 326

Published: Jan. 1, 2025

Language: Английский