Interaction Between Autophagy and the Inflammasome in Human Tumors: Implications for the Treatment of Human Cancers DOI Open Access
Qing Xia,

J Zhang

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 43(1)

Published: Dec. 25, 2024

ABSTRACT Autophagy is a physiologically regulated cellular process orchestrated by autophagy‐related genes (ATGs) that, depending on the tumor type and stage, can either promote or suppress growth progression. It also modulate cancer stem cell maintenance immune responses. Therefore, targeted manipulation of autophagy may inhibit development overcoming tumor‐promoting mechanisms. The inflammasome another multifunctional bioprocess that induces form pro‐inflammatory programmed death, called pyroptosis. Dysregulation overactivation has been implicated in pathogenesis development. Additionally, NLRP3 removing inflammatory drivers. Recent research suggests inflammasome, turn, affects autophagy. Understanding complex interplay between inflammasomes could lead to more precise effective strategies for treatments. In this review, we summarize impact dysregulation progression suppression. We then highlight their targeting treatment as monotherapy combination with other therapies. Furthermore, discuss interaction inflammation inflammasome. Finally, based recent findings, review potential treatment.

Language: Английский

Improvement of classical therapy in EGFR inhibitors-induced cutaneous adverse reaction by microneedle delivery and Astragalus polysaccharide DOI Creative Commons

Luzheng Zhang,

Jie Zhang, Yiwen Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140762 - 140762

Published: Feb. 6, 2025

Language: Английский

Citations

0
Rosmarinic Acid: A Potential Therapeutic Agent in Gastrointestinal Cancer Management—A Review DOI Open Access

Karolina Czerwińska,

Iwona Radziejewska

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11704 - 11704

Published: Oct. 31, 2024

Gastrointestinal cancers are still the leading cause of death worldwide. This is related, among other things, to non-specific symptoms, especially in initial stages, and also limited possibilities for treatment. Therefore, research being conducted improve detection this type cancer increase effectiveness therapy. The potential application natural compounds management deserves special attention. In group such products, there polyphenolic that reveal, e.g., anti-oxidative, anti-carcinogenic, anti-inflammatory, anti-diabetic, neuroprotective properties. One these polyphenols rosmarinic acid, commonly found plants as Boraginaceae Nepetoideae subfamilies Lamiaceae (mint) family. A number studies have considered positive effects acid treatment many cancers, including gastrointestinal ones oral, stomach, pancreas, colon, liver cancers. main aim paper was summarize mechanisms action

Language: Английский

Citations

1
Impact of Circadian Clock PER2 Gene Overexpression on Rumen Epithelial Cell Dynamics and VFA Transport Protein Expression DOI Open Access

Rahmat Ali,

Yongkang Zhen,

Xi Zanna

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12428 - 12428

Published: Nov. 19, 2024

The circadian gene

Language: Английский

Citations

0
Interaction Between Autophagy and the Inflammasome in Human Tumors: Implications for the Treatment of Human Cancers DOI Open Access
Qing Xia,

J Zhang

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 43(1)

Published: Dec. 25, 2024

ABSTRACT Autophagy is a physiologically regulated cellular process orchestrated by autophagy‐related genes (ATGs) that, depending on the tumor type and stage, can either promote or suppress growth progression. It also modulate cancer stem cell maintenance immune responses. Therefore, targeted manipulation of autophagy may inhibit development overcoming tumor‐promoting mechanisms. The inflammasome another multifunctional bioprocess that induces form pro‐inflammatory programmed death, called pyroptosis. Dysregulation overactivation has been implicated in pathogenesis development. Additionally, NLRP3 removing inflammatory drivers. Recent research suggests inflammasome, turn, affects autophagy. Understanding complex interplay between inflammasomes could lead to more precise effective strategies for treatments. In this review, we summarize impact dysregulation progression suppression. We then highlight their targeting treatment as monotherapy combination with other therapies. Furthermore, discuss interaction inflammation inflammasome. Finally, based recent findings, review potential treatment.

Language: Английский

Citations

0