Journal of Integrative Neuroscience,
Journal Year:
2024,
Volume and Issue:
23(12)
Published: Dec. 24, 2024
Postoperative
cognitive
dysfunction
(POCD)
represents
a
significant
clinical
concern,
particularly
among
elderly
surgical
patients.
It
is
characterized
by
decline
in
performance,
affecting
memory,
attention,
coordination,
orientation,
verbal
fluency,
and
executive
function.
This
abilities
leads
to
longer
hospital
stays
increased
mortality.
review
provides
comprehensive
overview
of
the
current
progress
understanding
relevant
pathogenic
factors,
possible
mechanisms,
diagnosing,
prevention
treatment
POCD,
as
well
suggesting
future
research
directions.
discusses
neuronal
damage,
susceptible
genes,
central
cholinergic
system,
nervous
system
(CNS)
inflammation,
stress
response
glucocorticoids,
oxidative
development
aiming
uncover
pathological
mechanism
develop
effective
strategies
for
POCD.
The
reasons
for
the
significant
impact
of
abnormal
tau
protein
phosphorylation
and
aggregation
on
Alzheimer's
disease
are
still
unknown.
This
study
used
bioinformatics
methods,
including
domain
search
tools,
to
investigate
pathogenic
mechanism
in
neurodegenerative
diseases.
reveals
that
possesses
domains
linked
Aging
Device.
These
include
pyruvate
kinase,
phosphatase,
telomere
binding,
transposition,
HNH
cas9,
replicon
helicase,
DNA
polymerase,
nuclease,
transcription
factors-like,
promoter
binding
(TATA-box),
enhancer
(Homeobox,
MADS-box,
HMG
box),
mitochondrial
localization
mtDNA
polymerase.
It
implies
protein's
kinase
supplies
ATP
energy
its
Device
function.
Cas9
,
reverse
transcriptase,
transposase
cut
sequence
between
"TAA"
from
then
transcript
guide
RNA
sequence.
factor
slides
specific
region.
excises
intron
region
complementary
RAN
nuclease
splice
or
add
fragment
We
thought
transposes
fragments
promoter/enhancer
might
mess
up
polymerase
II,
which
would
help
Device's
telomere-guided
gene
(DNA
nucleus
mitochondrial)
copy
number
decrement
regulation
system
work
better.
can
us
understand
how
stress
injuries,
like
low
blood
sugar
oxygen
levels,
cause
clump
together
phosphorylate,
turns
off
a
way
doesn't
make
sense.
Thus,
anomalous
aging
devices,
such
as
protein,
may
be
associated
with
diseases
Alzheimer
disease,
amyotrophic
lateral
sclerosis.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(7), P. 1623 - 1623
Published: July 22, 2024
In
Parkinson's
disease,
neuroinflammation
is
a
double-edged
sword;
when
inflammation
occurs
it
can
have
harmful
effects,
despite
its
important
role
in
battling
infections
and
healing
tissue.
Once
triggered
by
microglia,
astrocytes
acquire
reactive
state
shift
from
supporting
the
survival
of
neurons
to
causing
their
destruction.
Activated
microglia
Proteinase-activated
receptor-2
(PAR2)
are
key
points
regulation
neuroinflammation.
1-Piperidin
Propionic
Acid
(1-PPA)
has
been
recently
described
as
novel
inhibitor
PAR2.
The
aim
our
study
was
evaluate
effect
1-PPA
microglial
activation
disease.
Protein
aggregates
PAR2
expression
were
analyzed
using
Thioflavin
S
assay
immunofluorescence
cultured
human
fibroblasts
patients,
treated
or
untreated
with
1-PPA.
A
significant
decrease
amyloid
observed
after
treatment
all
patients.
parallel
expression,
which
higher
sporadic
also
both
at
transcriptional
protein
level.
addition,
mouse
LPS-activated
inflammatory
profile
significantly
downregulated
treatment,
remarkable
IL-1β,
IL-6,
TNF-α,
together
decreased
conclusion,
determines
reduction
neuroglia
formation,
suggesting
that
pharmacological
inhibition
could
be
proposed
strategy
control
Scientia Pharmaceutica,
Journal Year:
2024,
Volume and Issue:
92(4), P. 55 - 55
Published: Oct. 8, 2024
Acetaminophen
(APAP)
is
a
widely
used
analgesic
and
antipyretic,
whereas
benzo(a)pyrene
(B[a]P)
carcinogen
with
significant
global
health
risks
due
to
environmental
exposure.
While
APAP
generally
safe
at
therapeutic
doses,
co-exposure
B[a]P
can
exacerbate
its
toxicity.
This
study
aimed
identify
potential
human
target
proteins
for
through
inverse
molecular
docking
dynamics
simulations.
We
performed
B[a]P,
APAP,
three
metabolites
against
689
involved
in
various
biological
processes.
Five
were
selected
based
on
high
affinity
their
involvement
multiple
pathways.
Molecular
simulations
revealed
that
primarily
interacted
via
hydrophobic
π-stacking
interactions
like
LXR-β,
HSP90α,
HSP90β,
AKT1,
while
AM404
formed
hydrogen
bonds
interactions.
The
confirmed
the
complexes
had
conformational
stability,
except
protein
AKT1.
These
results
provide
insights
into
impacts
of
functions
implications
understanding
toxic
effects
combined
Journal of Integrative Neuroscience,
Journal Year:
2024,
Volume and Issue:
23(12)
Published: Dec. 24, 2024
Postoperative
cognitive
dysfunction
(POCD)
represents
a
significant
clinical
concern,
particularly
among
elderly
surgical
patients.
It
is
characterized
by
decline
in
performance,
affecting
memory,
attention,
coordination,
orientation,
verbal
fluency,
and
executive
function.
This
abilities
leads
to
longer
hospital
stays
increased
mortality.
review
provides
comprehensive
overview
of
the
current
progress
understanding
relevant
pathogenic
factors,
possible
mechanisms,
diagnosing,
prevention
treatment
POCD,
as
well
suggesting
future
research
directions.
discusses
neuronal
damage,
susceptible
genes,
central
cholinergic
system,
nervous
system
(CNS)
inflammation,
stress
response
glucocorticoids,
oxidative
development
aiming
uncover
pathological
mechanism
develop
effective
strategies
for
POCD.
