EGCG-Modified Bioactive Core–Shell Fibers Modulate Oxidative Stress to Synergistically Promote Vascularized Bone Regeneration
ACS Biomaterials Science & Engineering,
Journal Year:
2025,
Volume and Issue:
11(1), P. 543 - 555
Published: Jan. 2, 2025
Oxidative
stress
induced
by
reactive
oxygen
species
(ROS)
can
adversely
affect
tissue
repair,
whereas
endowing
biomaterials
with
antioxidant
activity
improve
the
in
vivo
microenvironment,
thereby
promoting
angiogenesis
and
osteogenesis.
Accordingly,
this
study
utilized
epigallocatechin-3-gallate
(EGCG),
a
material
known
for
its
reducing
properties,
oxidative
self-polymerization
capability,
strong
binding
characteristics,
to
modify
bioactive
core–shell
fibrous
membrane
(10RP-PG).
Compared
10RP-PG
membrane,
EGCG-modified
(E/10RP-PG)
exhibited
superior
hydrophilicity,
excellent
cell
adhesion,
compatibility.
Moreover,
effectively
scavenge
free
radicals,
ameliorate
local
foster
(enhancing
expression
of
angiogenic
genes
human
umbilical
vein
endothelial
cells
(HUVECs)
1.58
times
vascular
generation
area
upon
subcutaneous
implantation
4.47
times).
The
enhancement
E/10RP-PG
further
promoted
cartilage
degeneration
absorption,
as
well
new
bone
formation,
thus
facilitating
repair
defects.
This
provides
strategy
defect
through
surface
modification
an
agent,
fabricated
membranes
show
promise
guiding
vascularized
regeneration.
Language: Английский
Nanoclays in water treatment: Core concepts, modifications, and application insights
Journal of Water Process Engineering,
Journal Year:
2024,
Volume and Issue:
67, P. 106180 - 106180
Published: Sept. 28, 2024
Language: Английский
The Impact of Polyphosphates on the Colloidal Stability of Laponite Particles
The Journal of Physical Chemistry B,
Journal Year:
2024,
Volume and Issue:
128(28), P. 6957 - 6965
Published: July 9, 2024
The
effect
of
polyphosphate
(polyP)
adsorption
on
the
colloidal
properties
disc-shaped
laponite
(LRD)
particles
was
examined
in
aqueous
dispersions
with
a
focus
elucidating
interparticle
forces
that
govern
stability
systems.
charge
and
aggregation
rate
data
bare
LRD
exhibited
an
ionic
strength-dependent
trend,
confirming
presence
double-layer
repulsion
van
der
Waals
attraction
as
major
surface
interactions.
significantly
increased
magnitude
at
elevated
polyP
concentrations
result
subsequent
overcharging
positively
charged
sites
edges
discs.
A
transition
from
stable
to
unstable
colloids
observed
increasing
doses
indicating
formation
aggregates
latter
systems
due
depletion
and/or
bridging
interactions
induced
by
dissolved
or
adsorbed
polyP,
respectively.
degree
phosphate
polymerization
influenced
neither
nor
mechanism.
findings
clearly
confirm
driving
phenomenon
induce
particle
contrast
other
clay
types,
where
derivatives
act
dispersion
stabilizing
agents.
This
study
provides
valuable
insights
into
early
stages
involving
polyPs,
which
have
crucial
role
predicting
further
material
are
important
designing
LRD-polyP
composites
for
applications
such
potential
sources
chemical
fertilizers.
Language: Английский
pH-Controlled-Ion-Mobility of Laponite-Phosphate Dispersion for Physical Hydrogel with Improved Mechanical Properties and Sensitivity to CO2
Colloids and Surfaces A Physicochemical and Engineering Aspects,
Journal Year:
2024,
Volume and Issue:
705, P. 135743 - 135743
Published: Nov. 7, 2024
Language: Английский
Biodegradable Mechanically Robust PCL/Oligomeric PCL‐Diol/Laponite Antifouling Porous Membrane as a Versatile Adsorbent of Water Contaminants: A Sustainable Approach to Membrane Disposal
Journal of Applied Polymer Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 26, 2024
ABSTRACT
Biodegradable
polymeric
membranes
can
reduce
the
environmental
impact
of
polymer
waste
from
discarded
used
in
water
treatment
and
desalination.
Poly(ε‐caprolactone)
(PCL),
a
promising
biodegradable
material,
faces
limitations
due
to
its
hydrophobicity,
affecting
salt
contaminant
adsorption.
To
overcome
this,
PCL
was
blended
with
oligomeric
PCL‐diol
(PCL‐D)
ratios
90:10,
80:20,
70:30.
Additionally,
12
wt%
laponite
(Lap),
an
anionic
synthetic
clay,
incorporated
enhance
mechanical
strength
functionality.
The
addition
PCL‐D
improved
porosity,
hydrophilicity,
antifouling
properties,
while
Lap
enhanced
performance.
pure
flux
(PWF)
increased
~188
Lm
−2
h
−1
for
neat
1124
70:30
blend
(P7D3‐L12),
contact
angle
(WCA)
decreased
~96°
~49°.
P7D3‐L12
membrane
exhibited
excellent
adsorption
heavy
metals
(Pb
2+
~84.9
Cd
~90.6
mg/g)
dyes
(MB
~45
NR
~57
mg/g).
It
also
showed
~36%–40%
retention
after
multiple
cycles
fouling
recovery
rate
(FRR)
~82%
five
cycles.
demonstrated
78%
weight
loss
compost
over
54
days,
indicating
biodegradability.
These
modified
offer
solution
sustainable
treatment.
Language: Английский