Metal-Free Catalytic Synthesis of Tetrasubstituted Furans from α-Hydroxy Ketones and Cyano Compounds DOI Creative Commons

Yu Zeng,

Shi-Hang Yang,

Ji-Lin Guo

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(8), P. 1832 - 1832

Published: April 19, 2025

A novel method for the efficient and straightforward synthesis of tetrasubstituted furans is presented, employing a base-catalyzed reaction α-hydroxy ketones cyano compounds. The proceeds under relatively mild conditions, utilizes readily available starting materials, exhibits good functional group tolerance high yields. Notably, this obviates need expensive metal catalysts introduces crucial groups such as amino moieties. Furthermore, it avoids prerequisite functionalization substrates, thereby enhancing atomic economy.

Language: Английский

BF3-Catalyzed Nucleophilic Addition Reaction of 1,2-Diaminobenzenes with α-Ketoesters: Access to Cyclic α,α-Disubstituted α-Amino Acid Derivatives DOI
Zhen Yao, Ji Yang, Rong Huang

et al.

Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134487 - 134487

Published: Jan. 1, 2025

Language: Английский

Citations

0
Metal-Free Catalytic Synthesis of Tetrasubstituted Furans from α-Hydroxy Ketones and Cyano Compounds DOI Creative Commons

Yu Zeng,

Shi-Hang Yang,

Ji-Lin Guo

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(8), P. 1832 - 1832

Published: April 19, 2025

A novel method for the efficient and straightforward synthesis of tetrasubstituted furans is presented, employing a base-catalyzed reaction α-hydroxy ketones cyano compounds. The proceeds under relatively mild conditions, utilizes readily available starting materials, exhibits good functional group tolerance high yields. Notably, this obviates need expensive metal catalysts introduces crucial groups such as amino moieties. Furthermore, it avoids prerequisite functionalization substrates, thereby enhancing atomic economy.

Language: Английский

Citations

0