The Emerging Role of Nanoparticles Combined with Either Radiotherapy or Hyperthermia in Head and Neck Cancer: A Current Review
Cancers,
Journal Year:
2025,
Volume and Issue:
17(5), P. 899 - 899
Published: March 6, 2025
Head
and
neck
cancer
(HNC)
includes
various
malignancies
represents
the
seventh
most
common
worldwide.
The
early
diagnosis
of
HNC
results
in
a
70-90%
five-year
survival
rate,
which
declines
with
locally
advanced
stages
disease.
Current
care
employs
multimodal
strategy
encompassing
surgery,
radiation
therapy
(RT),
chemotherapy,
immunotherapy,
while
treatment
options
vary
according
to
stage,
tumor
features,
patient
characteristics.
About
75%
patients
will
benefit
from
RT,
either
as
primary
or
adjuvant
following
surgical
resection.
Technological
improvements
such
intensity-modulated
RT
(IMRT)
image-guided
(IGRT),
have
enhanced
targeting
minimized
adjacent
healthy
tissue
irradiation
also
expanding
recurrent
metastatic
setting.
Innovative
therapeutic
strategies
for
integrate
gene
therapy,
molecular
targeted
photodynamic
photothermal
nanoparticles
(NPs),
objective
optimizing
control
reducing
damage
normal
tissues.
NPs
are
emerging
possible
radiosensitizers
treatment,
enhancing
efficacy
immunotherapy.
In
vivo
vitro
studies
on
tumors
containing
gold
(Au),
gadolinium
(Gd),
hafnium
oxide
(HfO2)
show
promising
destruction
rates,
indicating
their
potential
clinical
application.
Hyperthermia,
investigated
an
adjunct
potentially
improves
outcomes
when
combined
advancements
nanotechnology
renewing
interest
this
approach
HNC.
At
present,
NBTXR3
is
sole
NP
that
being
trials
enhancement
RT.
Language: Английский
Selection of Sol-Gel Coatings by the Analytic Hierarchy Process and Life Cycle Assessment for Concentrated Solar Power Plants
Sustainability,
Journal Year:
2025,
Volume and Issue:
17(6), P. 2449 - 2449
Published: March 11, 2025
Sol-gel
coatings
are
commonly
used
to
prevent
corrosion
from
molten
salt
mixtures
in
CSP
plants.
Until
now,
they
have
been
driven
primarily
by
cost
considerations,
without
integrating
environmental
criteria
into
the
modeling
and
decision-making
process.
The
novelty
of
this
study
lies
development
an
evaluation
framework
that
incorporates
impact
alongside
technical
economic
factors,
providing
a
more
sustainable
approach.
This
work
assesses
porosity,
thermal
shock
resistance,
thickness
determine
optimal
sol-gel
coating.
For
purpose,
multi-criteria
technique
“Analytic
Hierarchy
Process”
(AHP)
Life
Cycle
Assessment
(LCA)
methodology
implemented.
results
show
scores
obtained
for
3YSZ-5A
(5%
mol)
coating
higher
than
those
3YSZ
(3%
3YSZ-20A
(20%
coatings,
between
1.52
1.69,
respectively.
is
solution
among
all
systems
analyzed,
with
score
0.61
AHP
pt.
same
type
molar
concentration
(20%)
achieved
0.55
Finally,
received
lowest
rating,
0.36
insights
generated
research
will
support
design
maintenance
Language: Английский