Synergistic Antifungal Activity of Terbinafine in Combination with Light-Activated Gelatin–Silver Nanoparticles Against Candida albicans Strains

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 125 - 125

Published: Jan. 17, 2025

The development of resistance to traditional antifungal therapies has necessitated the exploration alternative treatment strategies effectively manage fungal infections, particularly those induced by Candida albicans (C. albicans). This research investigates possibility integrating silver nanoparticles (AgNPs) with Terbinafine improve effectiveness. Terbinafine, while potent, faces challenges specific strains, highlighting need for enhance its efficacy. Silver were produced through a light-activated, gelatin-based method, resulting in particle sizes ranging from 56.8 nm 66.2 nm, confirmed dynamic light scattering and scanning electron microscopy. Stability studies indicated that AgNPs 30 mg nitrate (AgNO₃) exhibited greatest stability over 60 days across different temperature conditions. analysis UV-visible spectrophotometry revealed notable shift absorption spectra as AgNO₃ concentrations increased, which was associated strengthening plasmon resonance. effectiveness combination assessed against three strains C. (ATCC 10231, ATCC 90028, 18804). demonstrated strong properties minimum inhibitory (MIC) values 2-4 µg/mL, whereas on their own displayed moderate integrated formulation notably enhanced effectiveness, especially strain revealing synergistic effect (FIFi = 0.369). These results complemented findings time-to-kill assay, where same showed 3.2 log₁₀ CFU/mL decrease viable cell count. process boost activity entails disruption membrane internal components, probably result ion release generation free radicals. indicate may act powerful addressing resistant presenting an encouraging direction future treatments.

Language: Английский

Synthesis of compounds including cyclopropane ring: Selectivity in additions

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140807 - 140807

Published: Nov. 1, 2024

Language: Английский