Comprehensive analysis of dehydrated edible macroalgae: Volatile compounds, chemical profiles, biological activities, and cytotoxicity

Journal of Applied Phycology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract Seaweeds offer sustainable, low-calorie nutritional options to address global food demand. Their limited use is due a lack of understanding their flavor, influenced by volatile organic compounds (VOCs). This study aims expand knowledge sensory, bioactive, and chemical properties edible macroalgae ( Chondrus crispus, Gracilaria gracilis, Porphyra dioica, Pyropia haitanensis, Palmaria palmata, Ulva rigida ) analyzing VOCs, phenolics, proteins, free amino acids, sugars, bioactivities. Extracts were obtained using 80% ethanol (25ºC, 60 min). HS-SPME/GC–MS analyses identified distinct compounds, such as 3-methyl-1-butanol, 2-ethyl-1-hexanol, geranylacetone, trans -linalool oxide, trimethylpyrazine in P. haitanensis , Z )-4-heptenal dioica octanal, isophorone, heptanoic acid, 2,6-dimethylpyrazine, tetramethylpyrazine palmata 2-methyl-2-pentenal, 1-pentanol, 1-hexanol G. gracilis E )-2-pentenal, )-2,4-heptadienal, 5-ethyl-2-furaldehyde, α-terpineol, α-muurolene U. . Novel discovered (20), (4), C. crispus (10), (14), (11), (19). Red algae, especially / rich sugars. showed the strongest antioxidant anti-inflammatory properties, while demonstrated lipid peroxidation prevention. These results, with safe profile all evaluated macroalgae, underscore potential seaweeds innovative bioactive ingredients.

Language: Английский

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Unlocking the Therapeutic Potential of Algae-Derived Compounds in Hematological Malignancies

Cancers, Journal Year: 2025, Volume and Issue: 17(2), P. 318 - 318

Published: Jan. 20, 2025

Algae are a rich source of bioactive compounds that have wide range beneficial effects on human health and can show significant potential in the treatment hematological malignancies such as leukemia, lymphoma, multiple myeloma. These diseases often pose therapeutic challenge despite recent advances (e.g., use immunomodulatory drugs, proteasome inhibitors, CD38 monoclonal antibodies, stem cell transplant, targeted therapy). A considerable number patients experience relapses or resistance to applied therapies. Algal compounds, alone combination with chemotherapy other more advanced therapies, exhibited antitumor preclinical studies may improve disease outcomes. include ability induce apoptosis, inhibit tumor growth, immune responses. However, most these conducted vitro, without vivo validation clinical trials. This paper summarizes current evidence vitro algae extracts isolated myeloma lines. In addition, we address application algae-derived drug carriers their synergistic against hematologic malignancies.

Language: Английский

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Isolation and characterization of the Endophytic Actinomycetes from understudied seaweeds: Exploring the therapeutic potentials of Streptomyces coelicolor

South African Journal of Botany, Journal Year: 2025, Volume and Issue: 179, P. 112 - 123

Published: Feb. 18, 2025

Language: Английский

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Recent advances of edible marine algae-derived sulfated polysaccharides in antiviral treatments: challenges vs. opportunities

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 26, 2025

Marine polysaccharides, particularly those derived from red, brown, and green algae, have shown promising antiviral activity. Among them, sulfated polysaccharides are notable due to their broad-spectrum properties. These include direct viral destruction, inhibition of virus adsorption, disruption transcription replication, the stimulation host’s immunity. With low toxicity, minimal drug resistance, excellent biocompatibility, these represent candidates for development medications. For instance, carrageenan, a polysaccharide red fucoidan, polymer brown both been proven effectively inhibit infections. Sulfated such as found in Ulva species, also exhibit properties, including activity against Japanese encephalitis virus. function by blocking attachment viruses host cells or interfering with various stages life cycle. Moreover, marine enhance immune responses, thereby aiding clearance. Although findings highlight potential most studies conducted vitro animal models. Further clinical trials necessary validate effectiveness safety therapeutic use.

Language: Английский

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Microalgae and exercise: from molecular mechanisms and brain health to clinical perspectives in the context of 3P medicine

The EPMA Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Language: Английский

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