A Systematic Review of Spironolactone Nano-Formulations for Topical Treatment of Skin Hyperandrogenic Disorders and Chronic Wounds DOI Creative Commons

Saedah Dereiah,

Muhammad Usman Ghori, Barbara R. Conway

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 17(1), P. 27 - 27

Published: Dec. 27, 2024

Background/Objectives: Spironolactone (SP), an aldosterone inhibitor widely used to treat androgen-dependent disorders such as acne, hirsutism, and alopecia, has demonstrated therapeutic potential in both oral topical formulations. However, SP's low solubility poor bioavailability conventional formulations have driven the development of novel nanocarriers enhance its efficacy. This review systematically examines recent advancements SP-loaded nanocarriers, including lipid nanoparticles (LNPs), vesicular (VNPs), polymeric (PNPs), nanofibers (NFs). Methods: A search strategy was developed, relevant literature searched using databases Scopus, PubMed, Google Scholar. The process, screening, inclusion, exclusion criteria, adhered Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines. Results: comprehensive analysis 13 eligible research articles, corresponding 15 studies, highlights key aspects encapsulation efficiency, stability, particle size, vitro vivo Six studies focused on solid (SLNs) nanostructured carriers (NLCs), which were found improve skin permeation. Another six investigated ethosomes niosomes, demonstrating superior targeting penetration capabilities. Two (PNPs) showed effectiveness delivering SP hair follicles treatment alopecia acne. Additionally, one study indicated significant rosacea therapy. Conclusions: nanocarrier systems represent promising targeted further clinical are required optimize their safety, efficacy, delivery mechanisms.

Language: Английский

Recent advances in nanotechnology for Parkinson’s disease: diagnosis, treatment, and future perspectives DOI Creative Commons
Virendra Kumar Yadav, Seshathiri Dhanasekaran, Nisha Choudhary

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 22, 2025

Parkinson’s disease is a progressive neurodegenerative that destroys substantia nigra dopaminergic neurons, causing tremors, bradykinesia, rigidity, and postural instability. Current treatment approaches primarily focus on symptom management, employing pharmacological, non-pharmacological, surgical methods. However, these treatments often result in fluctuating symptoms, side effects, progression. Here, the authors have reviewed emerging field of nanomedicine as promising path for treatment, emphasizing its potential to overcome limitations traditional therapies. Nanomedicine utilizes nanoparticles targeted drug delivery, leveraging their small size high surface area volume ratio cross blood-brain barrier deliver therapeutic agents directly affected brain regions. Various nanoparticles, including lipid-based, polymeric, metallic, carbon-based, shown treatment. Additionally, nanocarrier systems like liposomes, nanogels, dendrimers, solid lipid offer controlled sustained release agents, enhancing bioavailability reducing effects. This review provides insights into pathophysiology disease, highlighting mechanisms neurodegeneration, role alpha-synuclein, disruption pathways. It further discusses application gene therapy conjunction with interventions.

Language: Английский

Citations

4
Current Advances in the Therapeutic Potential of Scutellarin: Novel Applications, Mechanisms, and Future Challenges. DOI Creative Commons
Great Iruoghene Edo, Alice Njolke Mafe, Patrick Othuke Akpoghelie

et al.

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100754 - 100754

Published: Jan. 1, 2025

Language: Английский

Citations

2
Enhancing the Solubility of Co-Formulated Hydrophobic Drugs by Incorporating Functionalized Nano-Structured Poly Lactic-co-glycolic Acid (nfPLGA) During Co-Precipitation DOI Creative Commons
Mohammad Saiful Islam, Somenath Mitra

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 77 - 77

Published: Jan. 8, 2025

Background/Objectives: The co-formulation of active pharmaceutical ingredients (APIs) is a growing strategy in biopharmaceutical development, particularly when it comes to improving solubility and bioavailability. This study explores co-precipitation method prepare co-formulated crystals griseofulvin (GF) dexamethasone (DXM), utilizing nanostructured, functionalized polylactic glycolic acid (nfPLGA) as enhancer. Methods: An antisolvent precipitation technique was employed incorporate nfPLGA at 3% concentration into the GF DXM, referred DXM-GF-nfPLGA. dissolution performance this formulation compared that pure drugs co-precipitated DXM-GF without nfPLGA. Results: Several characterization techniques, including electron microscopy (SEM), RAMAN, FTIR, TGA, XRD, were used analyze incorporation co-formulations. inclusion significantly enhanced initial rate both DXM DXM-GF-nfPLGA formulation, achieving maximum 100%, which not attained by or formulation. also reduced amount time taken reach 50% (T50) 80% (T80) dissolution. T50 values decreased from 52 82 min (for GF) 23 for DXM-GF-nfPLGA, T80 improved 50 outpacing compounds. Furthermore, incorporating crystal structures greatly accelerated rates, with rates reaching 650.92 µg/min 540.60 DXM-GF, while showed lower rates. Conclusions: work demonstrates enhances forming water channels within API via hydrogen-bonding interactions. innovative holds promise developing hydrophobic co-formulations faster

Language: Английский

Citations

1
Current Status of Gout Arthritis: Current Approaches to Gout Arthritis Treatment: Nanoparticles Delivery Systems Approach DOI Creative Commons
Yedi Herdiana, Yoga Windhu Wardhana, Insan Sunan Kurniawansyah

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 102 - 102

Published: Jan. 14, 2025

The deposition of monosodium urate (MSU) crystals within joint spaces produces a painful inflammatory condition known as gout, specific form arthritis. calls for combined curative and preventive management model. A new development in the approach to gout is that NLRP3-targeted biologic agents, such monoclonal therapies, provide more accurate treatment by blocking pro-inflammatory cytokines. Nanoparticle drug delivery enhances biological availability targets, which may increase therapeutic efficacy decrease general toxicity. again cannot be ignored, mainly keeping up certain modifications diet weight, along with pharmacological therapies reduce uric acid (UA) levels frequency acute attacks. advancement genetic profiling patients biomarker discoveries drives trend towards building individualized medicine care, quickly gaining ground most effective method delivering treatments individual patients, moving away from one-size-fits-all treatments. following paper aims an updated account focus on recent developments, order enhance these approaches, quality life standard treatment.

Language: Английский

Citations

1
Examination of CTAB-amoxicillin interactions in ethanol and propanol: Insights into surface chemistry and micellization dynamics DOI
Zaineb O. Ettarhouni,

Hager S. El-Beshti,

Ali A. Elhamasie

et al.

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 126935 - 126935

Published: Jan. 1, 2025

Language: Английский

Citations

1
Nanoparticles of Natural Product-derived Medicines: Beyond the Pandemic DOI Creative Commons
Yedi Herdiana

Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42739 - e42739

Published: Feb. 1, 2025

This review explores the synergistic potential of natural products and nanotechnology for viral infections, highlighting key antiviral, immunomodulatory, antioxidant properties to combat pandemics caused by highly infectious viruses. These often result in severe public health crises, particularly affecting vulnerable populations due respiratory complications increased mortality rates. A cytokine storm is initiated when an overload pro-inflammatory cytokines chemokines released, leading a systemic inflammatory response. Viral mutations limited availability effective drugs, vaccines, therapies contribute continuous transmission virus. The coronavirus disease-19 (COVID-19) pandemic has sparked renewed interest product-derived antivirals. efficacy traditional medicines against infections examined. Their anti-inflammatory, are highlighted. discusses how enhances herbal combating infections.

Language: Английский

Citations

1
Advances in Materials Science for Precision Melanoma Therapy: Nanotechnology-Enhanced Drug Delivery Systems DOI Creative Commons
Sivakumar S. Moni, Jobran M. Moshi, Sabine Matou‐Nasri

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 296 - 296

Published: Feb. 24, 2025

Melanoma, a highly aggressive form of skin cancer, poses major therapeutic challenge due to its metastatic potential, resistance conventional therapies, and the complexity tumor microenvironment (TME). Materials science nanotechnology advances have led using nanocarriers such as liposomes, dendrimers, polymeric nanoparticles, metallic nanoparticles transformative solutions for precision melanoma therapy. This review summarizes findings from Web Science, PubMed, EMBASE, Scopus, Google Scholar highlights role in overcoming treatment barriers. Nanoparticles facilitate passive active targeting through mechanisms enhanced permeability retention (EPR) effect functionalization with tumor-specific ligands, thereby improving accuracy drug delivery reducing systemic toxicity. Stimuli-responsive systems multi-stage further improve overcome challenges poor penetration resistance. Emerging platforms combine diagnostic imaging delivery, paving way personalized medicine. However, there are still issues scalability, biocompatibility, regulatory compliance. comprehensive potential integrating genetics proteomics, scalable, patient-specific therapies. These interdisciplinary innovations promise redefine provide safer, more effective, accessible treatments. Continued research is essential bridge gap between evidence-based scientific clinical applications.

Language: Английский

Citations

1
Botanical sources, biopharmaceutical profile, anticancer effects with mechanistic insight, toxicological and clinical evidence of prunetin: a literature review DOI

Sumaya Akter Bithi,

Md. Sakib Al Hasan, Md. Shimul Bhuia

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 3, 2025

Language: Английский

Citations

1
The Therapeutic Potential of Baicalin and Baicalein in Breast Cancer: A Systematic Review of Mechanisms and Efficacy DOI Creative Commons
Bartłomiej Zieniuk, Şuheda Uğur

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 181 - 181

Published: March 11, 2025

Cancer remains a leading cause of death globally, with breast cancer being the most commonly diagnosed in women. This systematic review focuses on therapeutic potential baicalin and baicalein, two bioactive flavonoids derived from Scutellaria baicalensis, treatment. These compounds exhibit anticancer properties through mechanisms such as apoptosis induction, cell cycle arrest, inhibition metastasis. Baicalin baicalein modulate key signaling pathways, including NF-κB, PI3K/AKT/mTOR, Wnt/β-catenin, have shown efficacy both vitro vivo models. Their synergy chemotherapy agents incorporation into nanotechnology-based delivery systems highlight opportunities to enhance outcomes. However, current evidence is predominantly preclinical, limited clinical trials validate their safety humans. Challenges poor bioavailability rapid metabolism also underscore need for advanced formulation strategies. synthesizes molecular mechanisms, efficacy, applications research.

Language: Английский

Citations

1
Hyaluronic Acid-Based pH-Sensitive Nanogel: Synthesis, Characterization, and Assessment for Acyclovir Delivery In Vitro and In Vivo DOI
Tarek A. A. Moussa, Heba Ali Abd El‐Rahman,

Riham R. Mohamed

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 26(1), P. 341 - 362

Published: Dec. 25, 2024

Acyclovir (ACV) is a potentially effective antiviral medication; however, it has serious drawback, which its poor solubility, bioavailability, and short half-life. The goal of this study to improve drawbacks through the synthesis nanogels. In study, cross-linked hyaluronic acid-grafted poly(acrylamide-co-itaconic acid) nanogel synthesized successfully free radical polymerization used as safe pH-responsive carrier for ACV. nanogels showed pH response in vitro vivo. prepared C5 (1:1 ratio acrylamide: itaconic), had highest grafting efficiency, maximum swelling, drug loading, release 7.4, higher than 1.2. Also, C5, large surface area, good stability, matrices shrank acidic medium protected drug, while basic medium, expanded released ACV sustained manner improved bioavailability half-life

Language: Английский

Citations

5