Distinct Roles of Common Genetic Variants and Their Contributions to Diabetes: MODY and Uncontrolled T2DM DOI Creative Commons
Shadi Bazzazzadehgan,

Zia Shariat‐Madar,

Fakhri Mahdi

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 414 - 414

Published: March 14, 2025

Type 2 diabetes mellitus (T2DM) encompasses a range of clinical manifestations, with uncontrolled leading to progressive or irreversible damage various organs. Numerous genes associated monogenic diabetes, exhibiting classical patterns inheritance (autosomal dominant recessive), have been identified. Additionally, involved in complex which interact environmental factors trigger the disease, also discovered. These genetic findings raised hopes that testing could enhance diagnostics, disease surveillance, treatment selection, and family counseling. However, accurate interpretation data remains significant challenge, as variants may not always be definitively classified either benign pathogenic. Research date, however, indicates periodic reevaluation has led more consistent findings, biases being steadily eliminated. This improved across diverse ethnicities. Clinical studies suggest risk information motivate patients adopt behaviors promote prevention management T2DM. Given features certain types overlap T2DM, considering role healthcare providers caring for prediabetic should consider part diagnostic process. review summarizes current knowledge most common explores novel therapeutic targets, discusses recent advancements pharmaceutical

Language: Английский

Distinct Roles of Common Genetic Variants and Their Contributions to Diabetes: MODY and Uncontrolled T2DM DOI Creative Commons
Shadi Bazzazzadehgan,

Zia Shariat‐Madar,

Fakhri Mahdi

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 414 - 414

Published: March 14, 2025

Type 2 diabetes mellitus (T2DM) encompasses a range of clinical manifestations, with uncontrolled leading to progressive or irreversible damage various organs. Numerous genes associated monogenic diabetes, exhibiting classical patterns inheritance (autosomal dominant recessive), have been identified. Additionally, involved in complex which interact environmental factors trigger the disease, also discovered. These genetic findings raised hopes that testing could enhance diagnostics, disease surveillance, treatment selection, and family counseling. However, accurate interpretation data remains significant challenge, as variants may not always be definitively classified either benign pathogenic. Research date, however, indicates periodic reevaluation has led more consistent findings, biases being steadily eliminated. This improved across diverse ethnicities. Clinical studies suggest risk information motivate patients adopt behaviors promote prevention management T2DM. Given features certain types overlap T2DM, considering role healthcare providers caring for prediabetic should consider part diagnostic process. review summarizes current knowledge most common explores novel therapeutic targets, discusses recent advancements pharmaceutical

Language: Английский

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