On the Use of Strong Proton Donors as a Tool for Overcoming Line Broadening in NMR: A Comment DOI Creative Commons
Pantelis Charisiadis,

Themistoklis Venianakis,

Christina Papaemmanouil

et al.

Magnetic Resonance in Chemistry, Journal Year: 2024, Volume and Issue: 63(3), P. 170 - 179

Published: Dec. 4, 2024

Overcoming line broadening of labile protons and achieving high-resolution NMR spectra is crucial for the structural conformational analysis organic molecules. Recently, Ma et al. (Magn. Reson. Chem. 2024, 62, 198-207) demonstrated effectiveness 2,2,2-trifluoroacetic acid (TFA) in sharpening signals nitrogen-containing compounds which exhibit prototropic tautomerization or isomerism using high molar ratio [acids]/[solute] ~ 5 to 200. In this commentary, we provide an overview earlier publications highlight extensive applications TFA enhancing resolution across a variety functional groups, with use very small ratios 10-3 10-2. The prospects unequivocal structure as starting point will be analyzed.

Language: Английский

On the Use of Strong Proton Donors as a Tool for Overcoming Line Broadening in NMR: A Comment DOI Creative Commons
Pantelis Charisiadis,

Themistoklis Venianakis,

Christina Papaemmanouil

et al.

Magnetic Resonance in Chemistry, Journal Year: 2024, Volume and Issue: 63(3), P. 170 - 179

Published: Dec. 4, 2024

Overcoming line broadening of labile protons and achieving high-resolution NMR spectra is crucial for the structural conformational analysis organic molecules. Recently, Ma et al. (Magn. Reson. Chem. 2024, 62, 198-207) demonstrated effectiveness 2,2,2-trifluoroacetic acid (TFA) in sharpening signals nitrogen-containing compounds which exhibit prototropic tautomerization or isomerism using high molar ratio [acids]/[solute] ~ 5 to 200. In this commentary, we provide an overview earlier publications highlight extensive applications TFA enhancing resolution across a variety functional groups, with use very small ratios 10-3 10-2. The prospects unequivocal structure as starting point will be analyzed.

Language: Английский

Citations

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