Comprehensive mini-review: therapeutic potential of cannabigerol – focus on the cardiovascular system DOI Creative Commons
Anna Krzyżewska, Monika Kloza, Hanna Kozłowska

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Backgrounds Cannabigerol (CBG) is a non-psychoactive phytocannabinoid with broad spectrum of biological effects. However, there still too little research on its safety especially effects the cardiovascular system. Due to agonist alpha-2-adrenergic receptors (α 2 AR), it speculated that may have applications in pharmacotherapy metabolic syndrome, particularly hypertension. Thus, aim our review was analyse therapeutic potential CBG diseases. Methods The based searches PubMed and Web Science databases. Keywords were used identify literature containing mechanistic information Results A shows exhibits hypotensive mice probably through α AR agonism. Other numerous vitro vivo studies show has anti-inflammatory, antioxidant also regulates cell apoptosis. improved tissue sensitivity insulin, showed efficacy inhibiting platelet aggregation. are reports adverse high doses liver architecture function, which calls into question usefulness profile. Conclusion Above mentioned beneficial properties suggest be useful treating hypertension syndrome. lack chronic administration parameters condition, necessary determine need for future other indications.

Language: Английский

Cannabis: Zone Aspects of Raw Plant Components in Sport—A Narrative Review DOI Open Access

Corina Flangea,

Mihaela Vlad, Roxana Popescu

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 861 - 861

Published: Feb. 28, 2025

Objectives/Background: The Cannabis genus contain a mixture of cannabinoids and other minor components which have been studied so far. In this narrative review, we highlight the main aspects polarized discussion between abuse toxicity versus benefits compounds found in sativa plant. Methods: We investigated databases such as PubMed, Google Scholar, Web Science World Anti-doping Agency (WADA) documents for scientific publications that can elucidate heated related to negative addiction, organ damage improved sports performance medical benefits, particularly athletes, some are promising nutrients. Results: Scientific arguments bring forward harmful effects cannabinoids, ethical legislative their usage doping substances sports. present synthesis metabolism cannabis along with identification methods routine anti-doping tests. Numerous studies attest beneficial effects, could therapeutic advantage athletes case injuries. These recommend nutrients, well potential pharmacological agents. Conclusions Future Perspectives: From perspective both illegal use investigators sport, there many interpretations, presented discussed review. Despite recent on species, is very little research active especially large groups compared placebo. may complete current vision topic clarify hypotheses launched discussions

Language: Английский

Citations

0
Comprehensive mini-review: therapeutic potential of cannabigerol – focus on the cardiovascular system DOI Creative Commons
Anna Krzyżewska, Monika Kloza, Hanna Kozłowska

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Backgrounds Cannabigerol (CBG) is a non-psychoactive phytocannabinoid with broad spectrum of biological effects. However, there still too little research on its safety especially effects the cardiovascular system. Due to agonist alpha-2-adrenergic receptors (α 2 AR), it speculated that may have applications in pharmacotherapy metabolic syndrome, particularly hypertension. Thus, aim our review was analyse therapeutic potential CBG diseases. Methods The based searches PubMed and Web Science databases. Keywords were used identify literature containing mechanistic information Results A shows exhibits hypotensive mice probably through α AR agonism. Other numerous vitro vivo studies show has anti-inflammatory, antioxidant also regulates cell apoptosis. improved tissue sensitivity insulin, showed efficacy inhibiting platelet aggregation. are reports adverse high doses liver architecture function, which calls into question usefulness profile. Conclusion Above mentioned beneficial properties suggest be useful treating hypertension syndrome. lack chronic administration parameters condition, necessary determine need for future other indications.

Language: Английский

Citations

0