Synthesis of 2,2,5-Trisubstituted Tetrahydrofurans by Ferrocenium-Catalyzed Dehydrative Diol Cyclization Reactions DOI Creative Commons

Cody D. Amann,

Khushboo Khushboo,

Eike B. Bauer

et al.

Inorganics, Journal Year: 2025, Volume and Issue: 13(2), P. 59 - 59

Published: Feb. 16, 2025

A ferrocenium-catalyzed synthesis of trisubstituted tetrahydrofurans by dehydrative cyclization diols is reported. Treatment γ-phenyl-γ-butyrolactone or valerolactone with 2–3 equivalents MeLi, n-BuLi, PhLi yielded the corresponding substituted 1,4-butanediols in 41–86% yields. Subsequent under non-inert conditions using catalytic ferrocenium tetrafluoroborate (10 mol%) produced 72–83% yields after 48–72 h at 45–70 °C CH2Cl2. This study demonstrates for first time, offering a convenient route to two steps from commercial easily accessible starting materials.

Language: Английский

Synthesis of 2,2,5-Trisubstituted Tetrahydrofurans by Ferrocenium-Catalyzed Dehydrative Diol Cyclization Reactions DOI Creative Commons

Cody D. Amann,

Khushboo Khushboo,

Eike B. Bauer

et al.

Inorganics, Journal Year: 2025, Volume and Issue: 13(2), P. 59 - 59

Published: Feb. 16, 2025

A ferrocenium-catalyzed synthesis of trisubstituted tetrahydrofurans by dehydrative cyclization diols is reported. Treatment γ-phenyl-γ-butyrolactone or valerolactone with 2–3 equivalents MeLi, n-BuLi, PhLi yielded the corresponding substituted 1,4-butanediols in 41–86% yields. Subsequent under non-inert conditions using catalytic ferrocenium tetrafluoroborate (10 mol%) produced 72–83% yields after 48–72 h at 45–70 °C CH2Cl2. This study demonstrates for first time, offering a convenient route to two steps from commercial easily accessible starting materials.

Language: Английский

Citations

0