Biocompatible Black Phosphorus Nanosheets-Antimicrobial Peptide Nanocomposites for Enhanced Anti-Infection Therapy DOI Creative Commons
Shuo Liu, Zhishang Shi, Lee‐Jene Teng

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 872 - 872

Published: Feb. 14, 2025

Bacterial infections are one of the major problems affecting human health, which is exacerbated by increasing antibiotic resistance. Antimicrobial peptides (AMPs) an ideal alternative to antibiotics, but their instability and toxicity mammalian cells need be addressed. Here, black phosphorus nanosheets (BPs) were successfully decorated with melittin (Mel), a kind AMP, through electrostatic interaction. The size impacts BPs on antibacterial ability biocompatibility BPs/Mel nanocomposites studied systematically. Results showed that made from middle-sized (BPs/Mel-7) have strong as well good biocompatibility. Moreover, BPs/Mel-7 could accelerate skin wound healing infected Staphylococcus aureus. This study provides facile strategy expand application AMPs.

Language: Английский

Biocompatible Black Phosphorus Nanosheets-Antimicrobial Peptide Nanocomposites for Enhanced Anti-Infection Therapy DOI Creative Commons
Shuo Liu, Zhishang Shi, Lee‐Jene Teng

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 872 - 872

Published: Feb. 14, 2025

Bacterial infections are one of the major problems affecting human health, which is exacerbated by increasing antibiotic resistance. Antimicrobial peptides (AMPs) an ideal alternative to antibiotics, but their instability and toxicity mammalian cells need be addressed. Here, black phosphorus nanosheets (BPs) were successfully decorated with melittin (Mel), a kind AMP, through electrostatic interaction. The size impacts BPs on antibacterial ability biocompatibility BPs/Mel nanocomposites studied systematically. Results showed that made from middle-sized (BPs/Mel-7) have strong as well good biocompatibility. Moreover, BPs/Mel-7 could accelerate skin wound healing infected Staphylococcus aureus. This study provides facile strategy expand application AMPs.

Language: Английский

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