Lipid rafts: novel therapeutic targets for metabolic, neurodegenerative, oncological, and cardiovascular diseases DOI Creative Commons
Mohamad Warda, Samet Tekin, Mahmoud Gamal

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 17, 2025

Lipid rafts are specialized microdomains within cellular membranes enriched with cholesterol and sphingolipids that play key roles in organization, signaling, homeostasis. This review highlights their involvement protein clustering, energy metabolism, oxidative stress responses, inflammation, autophagy, apoptosis. These findings clarify influence on trafficking, adhesion while interacting the extracellular matrix, cytoskeleton, ion channels, making them pivotal progression of various diseases. further addresses contributions to immune including autoimmune diseases, chronic cytokine storms. Additionally, role as entry points for pathogens has been demonstrated, raft-associated receptors being exploited by viruses bacteria increase infectivity evade defenses. Disruptions lipid raft dynamics linked signaling defects, which contribute metabolic, neurodegenerative, cardiovascular underscores potential therapeutic targets, discussing innovations such engineered transplantation. Advances analytical techniques mass spectrometry have expanded our understanding composition dynamics, opening new directions research. By consolidating current insights, we highlight need exploration molecular mechanisms.

Language: Английский

Characterization of metabolite profiles in milk derived exosomes from indicus, crossbred and taurine cows by proton nuclear magnetic resonance analysis DOI

Vidhi Garg,

Manishi Mukesh, Umesh Kumar

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 473, P. 143015 - 143015

Published: Jan. 23, 2025

Language: Английский

Citations

0
A new product containing secretome purified from bovine colostrum, Purasomes IRC100+, in the treatment of vaginal atrophy: in vitro study to evaluate safety and effectiveness DOI Creative Commons
Antonio Salvaggio, Anna Privitera,

Stefania Pennisi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Abstract Vaginal atrophy consists of the loss elasticity and thinning vaginal tissues mucous membranes. This is a condition that affects women especially during menopause, following hormonal decline resulting from cessation ovarian activity. The objective present study was evaluated effects Purasomes IRC100+ on proliferation migration VK2/E6E7 epithelial cells fibroblasts by in vitro experiments. We tested three different concentrations (0.5%, 1% 2%). found cell viability highest at 2% concentration for both lines. scratch-wound assay also done. Compared with scratch 0 h, all groups migrated after 24 significantly reduced treated compared to untreated cells. In particular, rates were 77% 82%, respectively IRC100+. Finally, this product promotes therefore it could improve wound healing.

Language: Английский

Citations

0
Lipid rafts: novel therapeutic targets for metabolic, neurodegenerative, oncological, and cardiovascular diseases DOI Creative Commons
Mohamad Warda, Samet Tekin, Mahmoud Gamal

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 17, 2025

Lipid rafts are specialized microdomains within cellular membranes enriched with cholesterol and sphingolipids that play key roles in organization, signaling, homeostasis. This review highlights their involvement protein clustering, energy metabolism, oxidative stress responses, inflammation, autophagy, apoptosis. These findings clarify influence on trafficking, adhesion while interacting the extracellular matrix, cytoskeleton, ion channels, making them pivotal progression of various diseases. further addresses contributions to immune including autoimmune diseases, chronic cytokine storms. Additionally, role as entry points for pathogens has been demonstrated, raft-associated receptors being exploited by viruses bacteria increase infectivity evade defenses. Disruptions lipid raft dynamics linked signaling defects, which contribute metabolic, neurodegenerative, cardiovascular underscores potential therapeutic targets, discussing innovations such engineered transplantation. Advances analytical techniques mass spectrometry have expanded our understanding composition dynamics, opening new directions research. By consolidating current insights, we highlight need exploration molecular mechanisms.

Language: Английский

Citations

0