The Antioxidant and Chemopreventive Activity of a Nutraceutical Derived from Brassicaceae Seed Extracts for Colorectal Cancer DOI Open Access
Ana Guzmán, Cristina Mesas, Kevin Doello

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1358 - 1358

Published: April 16, 2025

Background. Worldwide, colorectal cancer is the third most commonly diagnosed cancer. It second leading cause of cancer-related mortality. Recent studies establish a relationship between natural compounds from plants with prevention and treatment Specifically, glucosinolates antitumoral capacity polyphenols ability to scavenge free radicals that can cell damage have been identified in Brassicaceae family. Objectives. Based on previously mentioned factors, this study aimed develop nutraceutical made extracts different seeds its antioxidant antiproliferative action vitro vivo using AOM/DSS model CC57BL6J mice. Results. Extract Eruca sativa Sinapis alba showed highest among species studied were selected for formulation, which was potentially absorbable (73%) after an digestion process. In total, thirty could be responsible tumoral capacity. The intake successful intervention prevent development polyps by 31.6% their size 53.9%. When nutritional used combination physical exercise protocol, these parameters dropped 52.3% 62.6%, respectively. Conclusions. These findings suggest consumption diet rich bioactive Brassica species, activity, valuable strategy However, more research required evaluate efficacy safety interventions clinical settings.

Language: Английский

The Antioxidant and Chemopreventive Activity of a Nutraceutical Derived from Brassicaceae Seed Extracts for Colorectal Cancer DOI Open Access
Ana Guzmán, Cristina Mesas, Kevin Doello

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1358 - 1358

Published: April 16, 2025

Background. Worldwide, colorectal cancer is the third most commonly diagnosed cancer. It second leading cause of cancer-related mortality. Recent studies establish a relationship between natural compounds from plants with prevention and treatment Specifically, glucosinolates antitumoral capacity polyphenols ability to scavenge free radicals that can cell damage have been identified in Brassicaceae family. Objectives. Based on previously mentioned factors, this study aimed develop nutraceutical made extracts different seeds its antioxidant antiproliferative action vitro vivo using AOM/DSS model CC57BL6J mice. Results. Extract Eruca sativa Sinapis alba showed highest among species studied were selected for formulation, which was potentially absorbable (73%) after an digestion process. In total, thirty could be responsible tumoral capacity. The intake successful intervention prevent development polyps by 31.6% their size 53.9%. When nutritional used combination physical exercise protocol, these parameters dropped 52.3% 62.6%, respectively. Conclusions. These findings suggest consumption diet rich bioactive Brassica species, activity, valuable strategy However, more research required evaluate efficacy safety interventions clinical settings.

Language: Английский

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