Cerium oxide nanoparticles: a promising nanotherapy approach for chronic degenerative diseases DOI Creative Commons
Hugo Christian Monroy-Ramírez,

Jorge Salto-Sevilla,

Scarlet Arceo-Orozco

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 20(1)

Published: May 26, 2025

Abstract Oxidative stress is a process caused by excess-free radicals and reactive oxygen species (ROS), which contribute to the onset progression of various chronic degenerative diseases. Consequently, interest has grown in studying natural synthetic antioxidant compounds that restore normal ROS metabolism, alleviating damage affected tissues. Despite above, several preclinical clinical studies evaluating these therapies have shown some contradictory results since sometimes use molecules not desired therapeutic efficacy, or cases, antioxidants been related appearance harmful effects due their lack specificity, associated adverse effects, addition fact are essential for physiological functions. On other hand, nanotechnology one most widely used technological advances drug industry. Targeted delivery active ingredients combines knowledge pharmacology, pharmaceutical development, polymer sciences, conjugate chemistry, molecular biology improve pharmacokinetics ingredients, decreasing toxicity, immunogenicity, biorecognition. Cerium oxide nanoparticles (CeO 2 -NPs) emerged as novel alternative with high capacity, demonstrating beneficial both vivo vitro treating disorders. CeO -NPs only activated when levels reach threshold, protects healthy cells from unwanted effects. Their potential demonstrated multiple fields medicine, including oncology, neurology, ophthalmology, cardiology, hepatology. Therefore, this review addresses applications evaluated animal models diseases, help visualize position them an effective safe condition.

Language: Английский

Cerium oxide nanoparticles: a promising nanotherapy approach for chronic degenerative diseases DOI Creative Commons
Hugo Christian Monroy-Ramírez,

Jorge Salto-Sevilla,

Scarlet Arceo-Orozco

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 20(1)

Published: May 26, 2025

Abstract Oxidative stress is a process caused by excess-free radicals and reactive oxygen species (ROS), which contribute to the onset progression of various chronic degenerative diseases. Consequently, interest has grown in studying natural synthetic antioxidant compounds that restore normal ROS metabolism, alleviating damage affected tissues. Despite above, several preclinical clinical studies evaluating these therapies have shown some contradictory results since sometimes use molecules not desired therapeutic efficacy, or cases, antioxidants been related appearance harmful effects due their lack specificity, associated adverse effects, addition fact are essential for physiological functions. On other hand, nanotechnology one most widely used technological advances drug industry. Targeted delivery active ingredients combines knowledge pharmacology, pharmaceutical development, polymer sciences, conjugate chemistry, molecular biology improve pharmacokinetics ingredients, decreasing toxicity, immunogenicity, biorecognition. Cerium oxide nanoparticles (CeO 2 -NPs) emerged as novel alternative with high capacity, demonstrating beneficial both vivo vitro treating disorders. CeO -NPs only activated when levels reach threshold, protects healthy cells from unwanted effects. Their potential demonstrated multiple fields medicine, including oncology, neurology, ophthalmology, cardiology, hepatology. Therefore, this review addresses applications evaluated animal models diseases, help visualize position them an effective safe condition.

Language: Английский

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