Anti-Colorectal Cancer Activity of Panax and Its Active Components, Ginsenosides: A Review

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2593 - 2593

Published: March 13, 2025

Colorectal cancer (CRC) poses a significant health burden worldwide and necessitates novel treatment approaches with fewer side effects than conventional chemotherapy. Many natural compounds have been tested as possible treatments. Plants in the genus Panax widely studied due to their therapeutic potential for various diseases such inflammatory disorders cancers. Extracts from plants of activate upstream signals, including those related autophagy generation reactive oxygen species, induce intrinsic apoptosis CRC cells. The root extract notoginseng (P. notoginseng) regulated gut microbiota enhance T-cell-induced immune response against CRC. Protopanaxadiol (PPD)-type ginsenosides, especially Rh2, Rg3, Rb1, Rb2, significantly reduced proliferation cells tumor size xenograft mouse model, well targeting programmed death (PD)-1 block checkpoint Moreover, modified nanocarriers ginsenosides upregulated drug efficacy, showing that can also be utilized carriers. An increasing body studies has demonstrated curing Ginsenosides are promising active Panax, which support activity therapies.

Language: Английский

Synthesis of nanoparticles using advanced techniques

Next Nanotechnology, Journal Year: 2025, Volume and Issue: 8, P. 100169 - 100169

Published: Jan. 1, 2025

Language: Английский