Investigating the Application of Pomegranate-Loaded Chitosan Nanoparticles as Contrast Agents for Enhancing Breast Cancer Detection via Diffuse Reflectance Spectroscopy

Chemosensors, Journal Year: 2025, Volume and Issue: 13(2), P. 73 - 73

Published: Feb. 17, 2025

The present cancer diagnostic techniques and contrast agents suffer drawbacks, adverse effects, poor compatibility with patients due to health variations. To improve the detection of breast cancer, this work examined contrasted prospective applications pomegranates, chitosan nanoparticles (Cs NPs), pomegranate-loaded (PCs NPs) as for based on diffuse reflectance properties at following laser frequencies: red (670 nm) near-infrared (700 808 spectrum. Herein, a platform is proposed, offering promising pathway detection. PCs NPs two different pomegranate contents (2 5 g/L) were synthesized using sol–gel method. cytotoxicity developed nanomaterials human normal (Vero) (MCF7) cell lines evaluated in presence irradiation 670 nm, fluorescent effect was observed. chemical structures extract analyzed FTIR, they then further analytically characterized dynamic light scattering, zeta potential, field-emission scanning electron microscopy. Results confirmed structural stability nanomaterials. Cytotoxicity measurements revealed that achieved selective cytotoxic toward tumor cells. also showed significant wavelength-dependent changes characteristics between malignant NPs, content g/L, enhanced cells compared more than three folds. These findings indicate potential distinguish healthy reflection measurements.

Language: Английский

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Roadmap to Nanomedical Applications: Nanotoxicology and In Vitro Guidelines for Lanthanide‐Doped Luminescence Nanothermometers

Advanced NanoBiomed Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Lanthanide‐based luminescence nanothermometry has demonstrated unprecedented advantages in the development of nanotheranostic platforms for potential medical applications, yet despite exponential research progress and great enthusiasm across various related disciplines, a swift bench‐to‐bedside translation seems to be still out reach. This is predominantly fundamental issues at preclinical stage, such as complex nanomaterials design, incomplete optimization, fragmented characterization, insufficient validation nanothermometer performance physiological environments. The main impediments currently are important biophysicochemical that must addressed comprehensively, first foremost available vitro systems, before going on vivo investigations. review outlines critical perspective, well route suggestions underexplored aspects address significantly minimize existing translational gap.

Language: Английский

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Early cancer detection using the fluorescent Ashwagandha chitosan nanoparticles combined with near-infrared light diffusion characterization: in vitro study

Lasers in Medical Science, Journal Year: 2023, Volume and Issue: 38(1)

Published: Jan. 11, 2023

Early cancer diagnosis through characterizing light propagation and nanotechnology increases the survival rate. The present research is aimed at evaluating consequence of using natural nanoparticles in therapy diagnosis. Colon cells were differentiated from normal via investigating diffusion combined with fluorescence effect Ashwagandha chitosan (Ash C NPs). Ionic gelation technique synthesized Ash NPs. High-resolution transmission electron microscope, dynamic scattering, zeta potential characterized Fourier transform infrared spectroscopy analyzed NPs, chitosan, root water extract. Moreover, MTT assay evaluated cytotoxicity NPs under action near-infrared (NIR) irradiation. outcomes statistically by Bonferroni post hoc multiple two-group comparisons one-way variance analysis (ANOVA). Based on Monte-Carlo simulation technique, spatially resolved steady-state diffusely reflected cancerous healthy acquired. diffuse equation reconstructed optical fluence rate finite element technique. fluorescent was observed when irradiated NIR. revealed a decrease cell viability without laser based characterization after successfully for cells' surfaces showing different values. appeared its presence NIR laser.

Language: Английский

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Rare earth upconversion luminescent composite based on energy transfer for specific and sensitive detection of cysteine

The Analyst, Journal Year: 2023, Volume and Issue: 148(5), P. 1016 - 1023

Published: Jan. 1, 2023

Abnormal levels of thiols in cysteine (Cys) have been shown to be associated with growth retardation, skin lesions, and neurotoxicity humans. Herein, we designed synthesized a rare earth upconversion luminescent (UCL) nanocomposite probe UCNP-PEG-NOF1 for the UCL detection Cys using NOF1 developed by our group as probe. The core structure nanoparticles can absorb light at 980 nm convert it into visible light. principle was based on change absorption peak before after reaction between Cys, well intensity. could excited near-infrared had low background fluorescence strong penetration ability; thus, successfully employed specifically sensitively detect signal. Overall, good selectivity high sensitivity Cys; its limit 83 nM.

Language: Английский

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Perovskite quantum dots modulating upconversion nanomaterials for cancer early detections

Cancer Nanotechnology, Journal Year: 2023, Volume and Issue: 14(1)

Published: May 12, 2023

Abstract The accurate diagnosis and treatment of cancer cell lesions need a high standard detection technology. Fluorescent probes to perform biomarker have become popular research issue. However, fluorescent still face enormous challenges complex design difficult detection. In this work, we propose novel composite material UCNP@SiO 2 + QDs based on the combination rare earth upconversion (UCNPs) perovskite quantum dots (QDs) new probe MB-UCNP@SiO with molecular beacon (MB) as carrier, that can be excited by near-infrared light, emitted in visible wavelength, specifically identified highly sensitive. Under excitation 980 nm UCNPs produced maximum efficiency energy transfer through fluorescence resonance, multi-emission light synergistically re-emission QDs, is 70.6%. By changing doping ratio halogen elements it possible modulate precise luminescence entire wavelength range at different positions. obtained using Black Hole Quencher-1 (BHQ1) quenching groups linked two respective sides MB, selecting target myeloma miRNA-155, diagnostic developmental type, achieved specific recognition low concentration miRNA-155 limit 73.5 pM. This provide ideas for early cancer, tumors, cardiovascular diseases. Graphical

Language: Английский

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Biomedical optics and photonics for advanced clinical technologies

Optics & Laser Technology, Journal Year: 2024, Volume and Issue: 179, P. 111265 - 111265

Published: June 21, 2024

Language: Английский

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A high-efficient solar collector and converter designed by Ti-based metasurface with broadband NIR absorption and upconversion

Applied Materials Today, Journal Year: 2025, Volume and Issue: 43, P. 102649 - 102649

Published: Feb. 18, 2025

Language: Английский

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Recent Progress in CsPbX₃ (X = Cl, Br, and I) Perovskite Quantum Dot Glasses: Synthesis, Matrix Optimization, and Photonic Application Potentials

Laser & Photonics Review, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Abstract Perovskite quantum dots (PQDs) have emerged as prominent candidates for a variety of optoelectronic applications, including solar cells, white light‐emitting diodes (WLED), and liquid crystal displays (LCD), owing to their remarkable optical electronic properties. These properties encompass high absorption coefficients, elevated yields, tunable bandgaps, narrow emission peaks. Nonetheless, PQDs are inherently unstable due low formation energy ionic nature, making them susceptible degradation upon exposure light, heat, moisture. To address these challenges, encapsulating within an inorganic glass matrix has been proven effective. The rigid structure the significantly enhances stability while preserving exceptional characteristics. This review provides overview recent advancements in PQD glasses aims offer critical insights propel future research this domain. commonly employed preparation techniques reviewed, highlighting fundamental such structural integrity, performance, andstability, discussing approaches improve glasses, which include component regulation regulation. Additionally, potential applications diverse areas, WLED, LCD, temperature sensing explored.

Language: Английский

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Two-step upconversion-driven PDT/CDT cooperative phototherapeutic platform based on surface magnetic field modulation

Biophysical Chemistry, Journal Year: 2025, Volume and Issue: 323, P. 107454 - 107454

Published: May 5, 2025

Language: Английский

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Novel Fluorescent Probe Based on Rare-Earth Doped Upconversion Nanomaterials and Its Applications in Early Cancer Detection

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(11), P. 1787 - 1787

Published: May 24, 2022

In this paper, a novel rare-earth-doped upconverted nanomaterial NaYF4:Yb,Tm fluorescent probe is reported, which can detect cancer-related specific miRNAs in low abundance. The detection based on an upconversion of nanomaterials NaYF4:Yb,Tm, with emissions at 345, 362, 450, 477, 646, and 802 nm, upon excitation 980 nm. optimal Yb3+:Tm3+ doping ratio 40:1, the have strongest fluorescence. NaYF4:Yb, Tm nanoparticles were coated carboxylation or carboxylated protein, order to improve their water solubility biocompatibility. two commonly expressed proteins, miRNA-155 miRNA-150, detected by designed probe. results showed that probes distinguish well from partial complete base mismatch miRNA-155, effectively miRNA-150. preliminary indicate these good potential for protein disease diagnosis, including early cancer detection.

Language: Английский

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