Physicochemical properties of green synthesised ZnO nanoparticles and utilisation for treatment of breast cancer

Process Biochemistry, Journal Year: 2023, Volume and Issue: 129, P. 170 - 184

Published: March 16, 2023

Language: Английский

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MiR675-5p Acts on HIF-1α to Sustain Hypoxic Responses: A New Therapeutic Strategy for Glioma

Theranostics, Journal Year: 2016, Volume and Issue: 6(8), P. 1105 - 1118

Published: Jan. 1, 2016

Modern medicine relies on a small number of key biologics, which can be found in nature but require further characterization and purification before they used.Since the herbal remedy is given through dated ineffective method drug administration, its effectiveness diminished.The novel form delivery has potential to increase substances while decreasing their side effects.This main idea behind utilising different ways treatments.Several benefits arise from formulations compounds as compared conventional counterparts.These include enhanced penetrating ability into tissues, constant effective doses, resistance physical chemical degradation.Controlled targeted that components allow for more traditional dosing simultaneously increasing efficacy.Enhancing biodistribution target site accumulation systemically administered medicines goal nanomedicine formulations.The field nanotheranostics made significant advancements development by combining diagnostic therapeutic functions single nanoscale platform.It critically important create theranostic nanoplatform derived plants intrinsically "all-in-one" molecules.In addition examining mechanistic approach nanoparticle synthesis, this review highlights effects phytochemical systems.Furthermore, we have evaluated scope future field, discussed several nanoparticles been developed recently imaging, provided experimental evidence supports usage.

Language: Английский

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Sex-Dependent Differences in Colorectal Cancer: With a Focus on Obesity

Cells, Journal Year: 2022, Volume and Issue: 11(22), P. 3688 - 3688

Published: Nov. 20, 2022

Colorectal cancer (CRC) is the third most common and has second highest cancer-related mortality in world. The incident rates of CRC vary country-wise; however, population studies data from different countries show a general increase rate young adults, males, females ≥65 years. incidence affected by age, sex, environmental, dietary, hormonal, lifestyle factors. Obesity known disease that spreading rapidly throughout A large body literature indicates that, among many conditions, obesity increasing cause CRC. Even though one factors for development, limited are available explain mechanistic link between obesity, sex hormones, development. Thus, this review summarizes aims to understand sex-dependent differences CRC, especially context obesity.

Language: Английский

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UHPLC-HRMS-based Multiomics to Explore the Potential Mechanisms and Biomarkers for Colorectal Cancer

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 27, 2024

Abstract Background Understanding the metabolic changes in colorectal cancer (CRC) and exploring potential diagnostic biomarkers is crucial for elucidating its pathogenesis reducing mortality. Cancer cells are typically derived from tissues can be easily obtained cultured. Systematic studies on CRC at different stages still lacking. Additionally, there a need to validate our previous findings human serum. Methods Ultrahigh-performance liquid chromatography tandem high-resolution mass spectrometry (UHPLC-HRMS)-based metabolomics lipidomics were employed comprehensively measure metabolites lipids four serum samples normal control (NR) subjects. Univariate multivariate statistical analyses applied select differential between groups. Biomarkers with good efficacy that existed both screened by receiver operating characteristic curve (ROC) analysis. Furthermore, validated using metabolite standards. Results Metabolite lipid profiles differed significantly among A, B, C, D. Dysregulation of glycerophospholipid (GPL), fatty acid (FA), amino (AA) metabolism played role progression, particularly GPL dominated phosphatidylcholine (PC). A total 46 29 common discovered. Eight showed same trends patients compared Among them, palmitoylcarnitine sphingosine could serve as values area under (AUC) more than 0.80 cells. Their panel exhibited excellent performance discriminating (AUC = 1.00). Conclusions To knowledge, this first research attempt results cell models. The disorders PC, FA, AA closely related tumorigenesis CRC, PC being critical factor. composed may act biomarker diagnosis aiding prevention.

Language: Английский

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Accurate colorectal cancer detection using a random hinge exponential distribution coupled attention network on pathological images

Abdominal Radiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Language: Английский

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