Iron oxide-coupled CRISPR-nCas9-based genome editing assessment in mucopolysaccharidosis IVA mice DOI Creative Commons
Andrés Felipe Leal, Betül Çelik,

Nidhi Fnu

et al.

Molecular Therapy — Methods & Clinical Development, Journal Year: 2023, Volume and Issue: 31, P. 101153 - 101153

Published: Nov. 7, 2023

Mucopolysaccharidosis (MPS) IVA is a lysosomal storage disorder caused by mutations in the GALNS gene that leads to accumulation of keratan sulfate (KS) and chondroitin 6-sulfate, causing skeletal dysplasia cardiopulmonary complications. Current enzyme replacement therapy does not impact bone manifestation disease, supporting new therapeutic alternatives are required. We previously demonstrated suitability CRISPR-nCas9 system rescue phenotype human MPS fibroblasts using iron oxide nanoparticles (IONPs) as non-viral vectors. Here, we have extended this strategy an mouse model inserting cDNA into ROSA26 locus. The results showed increased activity, mono-KS reduction, partial recovery pathology, non-IONPs-related toxicity or antibody-mediated immune response activation. This study provides, for first time, vivo evidence potential CRISPR-nCas9-based treating vectors carriers.

Language: Английский

Doxorubicin-Loaded Iron Oxide Nanoparticles Induce Oxidative Stress and Cell Cycle Arrest in Breast Cancer Cells DOI Creative Commons
Elisa Parcero Hernandes, Danielle Lazarin-Bidóia, Raquel Dosciatti Bini

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 237 - 237

Published: Jan. 20, 2023

Cancer is one of the most common diseases nowadays and derives from uncontrollable growth a single cell. Magnetic nanoparticles (NpMag) offer various possibilities for use in biomedical area, including drug delivery mediated by magnetic fields. In current study, we evaluated vitro effects iron-oxide conjugated with antitumor doxorubicin (Dox) on human breast cancer cells. Our results revealed that Dox (NpMag+Dox) induce cellular redox imbalance MCF-7 We also demonstrate functionalized oxidative stress evidenced DNA damage, lipid peroxidation, cell membrane disruption, loss mitochondria potential. As result, NpMag+Dox drives cells to stop cycle decrease migration. The association NpMg+Dox induced better MCF cells, mainly presence field, increasing death which might reduce toxicity healthy providing efficacy treatment. Thus, may be candidate anticancer therapy.

Language: Английский

Citations

43
Influence of Physicochemical Properties of Iron Oxide Nanoparticles on Their Antibacterial Activity DOI Creative Commons
Kishan Nandi Shoudho, Shihab Uddin, Md. Mahamudul Hasan Rumon

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(31), P. 33303 - 33334

Published: July 25, 2024

The increasing occurrence of infectious diseases caused by antimicrobial resistance organisms urged the necessity to develop more potent, selective, and safe agents. unique magnetic tunable properties iron oxide nanoparticles (IONPs) make them a promising candidate for different theragnostic applications, including Though IONPs act as nonspecific agent, their activities are directly or indirectly linked with synthesis methods, synthesizing precursors, size, shapes, concentration, surface modifications. Alteration these parameters could accelerate decelerate production reactive oxygen species (ROS). An increase in ROS role disrupts bacterial cell walls, membranes, alters major biomolecules (e.g., lipids, proteins, nucleic acids), affects metabolic processes Krebs cycle, fatty acid synthesis, ATP glycolysis, mitophagy). In this review, we will investigate antibacterial activity bare surface-modified influence physiochemical on activity. Additionally, report potential mechanism IONPs' action driving

Language: Английский

Citations

16
Metal and Metal Oxides Nanoparticles and Nanosystems in Anticancer and Antiviral Theragnostic Agents DOI Creative Commons
Т. И. Шабатина, O. I. Vernaya,

N. L. Shimanovskiy

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(4), P. 1181 - 1181

Published: April 7, 2023

The development of antiviral treatment and anticancer theragnostic agents in recent decades has been associated with nanotechnologies, primarily inorganic nanoparticles (INPs) metal oxides. large specific surface area its high activity make it easy to functionalize INPs various coatings (to increase their stability reduce toxicity), (allowing retention the affected organ or tissue), drug molecules (for antitumor therapy). ability magnetic (MNPs) iron oxides ferrites enhance proton relaxation tissues serve as resonance imaging contrast is one most promising applications nanomedicine. Activation MNPs during hyperthermia by an external alternating field a method for targeted cancer therapy. As therapeutic tools, are carriers delivery pharmaceuticals (either antiviral) via targeting (in case MNPs), passive active (by attaching affinity ligands) targeting. plasmonic properties Au (NPs) application photothermal photodynamic therapies have extensively explored recently tumor treatment. Ag NPs alone combination medicines reveal new possibilities prospects relation hyperthermia, therapies, imaging, framework therapy presented this review.

Language: Английский

Citations

37
Recent Advances in Nanoparticle-Mediated Co-Delivery System: A Promising Strategy in Medical and Agricultural Field DOI Open Access
Mingshan Li, Xiaowei Sun, Meizhen Yin

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5121 - 5121

Published: March 7, 2023

Drug and gene delivery systems mediated by nanoparticles have been widely studied for life science in the past decade. The application of nano-delivery can dramatically improve stability efficiency carried ingredients, overcoming defects administration routes cancer therapy, possibly maintaining sustainability agricultural systems. However, a drug or alone sometimes cannot achieve satisfactory effect. nanoparticle-mediated co-delivery system load multiple drugs genes simultaneously, effectiveness each component, thus amplifying efficacy exhibiting synergistic effects therapy pest management. has reported medical field, studies on its field recently begun to emerge. In this progress report, we summarize recent preparation discuss remaining challenges future perspectives design fabrication.

Language: Английский

Citations

26
Iron Oxide Nanoparticles in Cancer Treatment: Cell Responses and the Potency to Improve Radiosensitivity DOI Creative Commons
Maria V. Shestovskaya, Anna L. Luss, Bezborodova Si

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(10), P. 2406 - 2406

Published: Sept. 30, 2023

The main concept of radiosensitization is making the tumor tissue more responsive to ionizing radiation, which leads an increase in potency radiation therapy and allows for decreasing dose concomitant side effects. Radiosensitization by metal oxide nanoparticles widely discussed, but range mechanisms studied not sufficiently codified often does reflect ability nanocarriers have a specific impact on cells. This review focused magnetic iron while they occupied special niche among prospective radiosensitizers due unique physicochemical characteristics reactivity. We collected data about possible molecular underlying radiosensitizing effects (IONPs) approaches their therapeutic efficacy variable modifications.

Language: Английский

Citations

24
Magnetic Nanoparticles: A Comprehensive Review from Synthesis to Biomedical Frontiers DOI

Shlok Mishra,

Manishkumar D. Yadav

Langmuir, Journal Year: 2024, Volume and Issue: 40(33), P. 17239 - 17269

Published: Aug. 12, 2024

Nanotechnology has opened new doors of exploration, particularly in materials science and healthcare. Magnetic nanoparticles (MNP), the tiny magnets, because their various properties, have potential to bring about radical changes field medicine. The distinctive surface chemistry, nontoxicity, biocompatibility, and, particular, inducible magnetic moment attracted a great deal interest morphological structures from variety scientific domains. This review presents concise overview MNPs crucial properties synthesis routes. It also aims highlight continuous methods available for MNP production. In recent years, use computational understanding behavior been on rise. Thus, we discuss numerical models developed understand how can be used hyperthermia targeting Circle Wilis. With increasing biomedical applications, it becomes necessary mechanisms toxicity, which are elucidated this review. focuses applications drug delivery, theranostics, MRI contrasting agents. We anticipate that article will broaden perspective help functionality applicability better.

Language: Английский

Citations

12
SPIONs: Superparamagnetic iron oxide-based nanoparticles for the delivery of microRNAi-therapeutics in cancer DOI
Göknur Kara, Bülent Özpolat

Biomedical Microdevices, Journal Year: 2024, Volume and Issue: 26(1)

Published: Feb. 7, 2024

Language: Английский

Citations

9
Iron oxide nanoparticles: The versatility of the magnetic and functionalized nanomaterials in targeting drugs, and gene deliveries with effectual magnetofection DOI
Salim Albukhaty, Ghassan M. Sulaiman, Hassan Al-Karagoly

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105838 - 105838

Published: June 3, 2024

Language: Английский

Citations

9
Iron Oxide Nanoparticles: Parameters for Optimized Photoconversion Efficiency in Synergistic Cancer Treatment DOI Creative Commons
Tsenka Grancharova, Plamen Zagorchev, Bissera Pilicheva

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(8), P. 207 - 207

Published: July 25, 2024

Photothermal therapy (PTT) can overcome cancer treatment resistance by enhancing the cell membrane permeability, facilitating drug accumulation, and promoting release within tumor tissue. Iron oxide nanoparticles (IONPs) have emerged as effective agents for PTT due to their unique properties biocompatibility. Approved of anemia, MRI contrast agents, magnetic hyperthermia mediators, IONPs also offer excellent light-to-heat conversion be manipulated using external fields targeted accumulation in specific Optimizing parameters such laser wavelength, power density, shape, size, iron oxidation state, functionalization, concentration is crucial IONPs' effectiveness. In addition PTT, enhance other modalities. They improve oxygenation, efficacy radiotherapy photodynamic therapy. trigger ferroptosis, a programmed death pathway mediated iron-dependent lipid peroxidation. Their magneto-mechanical effect allows them exert mechanical force on cells destroy tumors, minimizing damage healthy This review outlines strategies management photothermal performance efficiency with nanoparticles, well synergies therapies.

Language: Английский

Citations

9
Micro and Nano Interdigitated Electrode Array (IDEA)-Based MEMS/NEMS as Electrochemical Transducers: A Review DOI Creative Commons
Elyana Kosri, Fatimah Ibrahim, Aung Thiha

et al.

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(23), P. 4171 - 4171

Published: Nov. 24, 2022

Micro and nano interdigitated electrode array (µ/n-IDEA) configurations are prominent working electrodes in the fabrication of electrochemical sensors/biosensors, as their design benefits sensor achievement. This paper reviews µ/n-IDEA four-electrode sensors terms two-dimensional (2D) planar IDEA three-dimensional (3D) using carbon or metal starting materials. In this regard, enhancement IDEAs-based biosensors focuses on controlling width gap measurements between adjacent fingers increases IDEA’s height. Several distinctive methods used to expand surface area 3D IDEAs, such a unique design, integration mesh, microchannel, vertically aligned nanotubes (VACNT), nanoparticles, demonstrated discussed. More notably, conventional system, consisting reference counter will be compared highly novel two-electrode system that adopts shape. Compared 2D IDEA, expansion IDEAs significant changes performance sensors. Furthermore, challenges faced by current potential solutions for future directions presented herein.

Language: Английский

Citations

30