Approaches to Enhance the Potency of Vaccines in Chickens DOI Creative Commons

Oenone Bodman-Harris,

Christine S. Rollier, Munir Iqbal

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(12), P. 1337 - 1337

Published: Nov. 27, 2024

Outbreaks of avian pathogens such as Newcastle disease virus, influenza and salmonella have a major impact on economies food security worldwide. Some also pose significant zoonotic potential, especially viruses. Vaccination plays key role in controlling many poultry diseases, there are vaccines licenced the United Kingdom for diseases caused by viruses, bacteria, parasites. However, these often do not provide complete protection can cause unwanted side effects. Several factors affect potency vaccines, including type vaccination used, mechanism delivery, use adjuvants. Advancements technology led to study development novel vaccine adjuvants poultry. These induce stronger immune responses compared with current potential protect against multiple diseases. This review aims discuss existing technology; effect delivery mechanisms efficacy; adjuvants; ability target antigens antigen-presenting cells; probiotics, multivalent nanotechnology enhance vaccines.

Language: Английский

Revolutionizing Nanovaccines: A New Era of Immunization DOI Creative Commons
Mohammed A. Saleh,

Ahmed El-Moghazy,

Adel Helmy Elgohary

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(2), P. 126 - 126

Published: Jan. 27, 2025

Infectious diseases continue to pose a significant global health threat. To combat these challenges, innovative vaccine technologies are urgently needed. Nanoparticles (NPs) have unique properties and emerged as promising platform for developing next-generation vaccines. revolutionizing the field of development, offering new era immunization. They allow creation more effective, stable, easily deliverable Various types NPs, including lipid, polymeric, metal, virus-like particles, can be employed encapsulate deliver components, such mRNA or protein antigens. These NPs protect antigens from degradation, target them specific immune cells, enhance antigen presentation, leading robust durable responses. Additionally, simultaneously multiple antigens, adjuvants, in single formulation, simplifying production administration. Nanovaccines offer approach food- water-borne bacterial diseases, surpassing traditional formulations. Further research is needed address burden infections. This review highlights potential revolutionize platforms. We explore their mechanisms action, current applications, emerging trends. The discusses limitations nanovaccines, solutions role artificial intelligence effective accessible nanovaccines infectious diseases.

Language: Английский

Citations

0
Evaluation of Zein Nanoparticles as Delivery Agents of SARS-CoV-2 Antigens DOI Creative Commons
Verónica A. Márquez-Escobar,

María José Alonso-Cerda,

Sergio Rosales‐Mendoza

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(2), P. 139 - 139

Published: Jan. 28, 2025

Background/Objectives: Nanovaccines have significant potential to enhance immunization strategies by improving efficacy, safety, and cost-effectiveness. In particular, organic nanoparticles hold promise for the generation of low-cost nanovaccines obtained environmentally friendly methods. this study, feasibility using zein (NPs) as carriers an antigenic peptide (p30) receptor binding domain (RBD) from SARS-CoV-2 spike protein was explored. Methods: A synthesis method NPs established combining previously reported techniques, resulting were characterized in terms morphology, particle size, polydispersity index (PDI), surface charge, colloidal stability dynamic light scattering (DLS) transmission electron microscopy (TEM). Tween 20 employed a surfactant prevent aggregation. Results: The deemed safe based on vitro cytotoxicity assay Vero cells. Immunogenicity assessments demonstrated that NPs:p30 NPs:RBD induced IgG responses test mice, whose magnitude comparable those achieved with alum adjuvant. Conclusions: These findings support use promising vaccine delivery vehicles adjuvant effects due their ease synthesis, high stability, low cost.

Language: Английский

Citations

0
Nanoparticle-mediated enhancement of DNA Vaccines: Revolutionizing immunization strategies DOI

Pegah Yaraghi,

Abbas Kheyri,

Narges Mikaeili

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 302, P. 140558 - 140558

Published: Feb. 1, 2025

Language: Английский

Citations

0
Breaking barriers: Smart vaccine platforms for cancer immunomodulation DOI Creative Commons
Mohammad Mahmoudi Gomari,

Taha Ghantabpour,

Nima Pourgholamamiji

et al.

Cancer Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract Despite significant advancements in cancer treatment, current therapies often fail to completely eradicate malignant cells. This shortfall underscores the urgent need explore alternative approaches such as vaccines. Leveraging immune system's natural ability target and kill cells holds great therapeutic potential. However, development of vaccines is hindered by several challenges, including low stability, inadequate response activation, immunosuppressive tumor microenvironment, which limit their efficacy. Recent progress various fields, click chemistry, nanotechnology, exosome engineering, neoantigen design, offer innovative solutions these challenges. These achievements have led emergence smart vaccine platforms (SVPs), integrate protective carriers for messenger ribonucleic acid (mRNA) with functionalization strategies optimize targeted delivery. Click chemistry further enhances SVP performance improving encapsulation mRNA antigens facilitating precise delivery review highlights latest developments technologies therapy, exploring both opportunities challenges advancing transformative approaches.

Language: Английский

Citations

0
Nanotherapeutics as vaccines and their regulatory aspects DOI

Sneha Poddar,

Sahil Kumar, Gurpreet Kaur

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 63 - 77

Published: Jan. 1, 2025

Language: Английский

Citations

0
From Microbial Ecology to Clinical Challenges: The Respiratory Microbiome’s Role in Antibiotic Resistance DOI Creative Commons
Adelina-Gabriela Niculescu,

Mihaela Magdalena Mitache,

Alexandru Mihai Grumezescu

et al.

Pathogens, Journal Year: 2025, Volume and Issue: 14(4), P. 355 - 355

Published: April 5, 2025

Antibiotic resistance represents a growing public health threat, with airborne drug-resistant strains being especially alarming due to their ease of transmission and association severe respiratory infections. The microbiome plays pivotal role in maintaining health, influencing the dynamics antibiotic among pathogenic microorganisms. In this context, review proposes exploration complex interplay between microbiota antimicrobial resistance, highlighting implications diversity disease. Moreover, strategies mitigate including stewardship programs, alternatives traditional antibiotics, probiotics, restoration techniques, nanotechnology-based therapeutic interventions, are critically presented, setting an updated framework current management options. Therefore, through better understanding roles alongside emerging strategies, paper aims shed light on how global challenges posed by multi-drug-resistant pathogens can be addressed.

Language: Английский

Citations

0
Unraveling the Nano World in Paracoccidioidomycosis: Promising Applications of Nanotechnology in Diagnosis, Treatment, and Vaccines: A Mini Review DOI
Ricardo Cervini, Ariana Centa, Claudriana Locatelli

et al.

Current Microbiology, Journal Year: 2025, Volume and Issue: 82(6)

Published: April 28, 2025

Language: Английский

Citations

0
Advances in the Functionalization of Vaccine Delivery Systems: Innovative Strategies and Translational Perspectives DOI Creative Commons
Ingrid Andrêssa de Moura, Anna Jéssica Duarte Silva, Larissa Silva de Macêdo

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 640 - 640

Published: May 12, 2025

The development of effective vaccines requires a rational design that considers the interaction between antigens, their vectors, and immune system in addition to activation pathways induce safe specific response. efficacy vaccine formulation depends on nature antigen, protection offered by delivery system, ability potentiate response, precise release immunogen. Carrier systems such as lipid nanoparticles, polymers, exosomes, microorganisms can be functionalized chemical, physical, or biological methods generate selective improved biodistribution profiles. These enhance with target cells, thereby improving immunological efficacy. conjugation ligands modification parameters shape, charge, size vectors specificity, stability, efficiency antigen transport cellular compartments, facilitating robust This study examines modifications systems, focusing biomolecules physicochemical changes presentation. Additionally, we examine innovative methods, including microneedles, electroporation, needle-free show potential for enhancing

Language: Английский

Citations

0
Immunomodulatory activity of polycaprolactone nanoparticles with calcium phosphate salts against Leishmania infantum infection DOI Creative Commons
Kübra Kelleci, Adil Allahverdiyev,

Melahat Bağırova

et al.

Asian Pacific Journal of Tropical Biomedicine, Journal Year: 2024, Volume and Issue: 14(8), P. 359 - 368

Published: Aug. 1, 2024

Objective: To prepare and characterize polycaprolactone (PCL) nanoparticles loaded with sonicator fragmented (SLA) freeze- thaw Leishmania antigens (FTLA) to investigate the in vitro immunogenicity of antigen-encapsulated calcium phosphate adjuvant. Methods: The water/oil/water binary emulsion solvent evaporation method was used synthesize antigen-loaded PCL nanoparticles. Particles were characterized by scanning electron microscopy zeta potential measurements. Their cytotoxicity J774 macrophages determined MTT analysis. In addition, amount nitric oxide level cytokines produced Griess reaction ELISA method, respectively. protective effect developed formulations evaluated determining infection index percentage infected infantum . Results: Compared control group, SLA FTLA adjuvant induced a 6- 7-fold increase oxide, Additionally, vaccine promoted production IFN-γ IL-12. combined caused an approximately 13- 11-fold reduction index, respectively, compared group. Conclusions: encapsulation obtained both sonication freeze-thawing into show strong immune stimulating properties. Therefore, PCL-based antigen delivery systems are recommended as candidate against leishmaniasis.

Language: Английский

Citations

3
Polyanhydride nanovaccine against H3N2 influenza A virus generates mucosal resident and systemic immunity promoting protection DOI Creative Commons
Christopher E. Lopez, Zeb R. Zacharias, Kathleen A. Ross

et al.

npj Vaccines, Journal Year: 2024, Volume and Issue: 9(1)

Published: May 31, 2024

Influenza A virus (IAV) causes significant morbidity and mortality worldwide due to seasonal epidemics periodic pandemics. The antigenic drift/shift of IAV continually gives rise new strains subtypes, aiding in circumventing previously established immunity. As a result, there has been substantial interest developing broadly protective vaccine that induces, durable immunity against multiple IAVs. Previously, polyanhydride nanoparticle-based or nanovaccine (IAV-nanovax) encapsulating H1N1 antigens was reported, which induced pulmonary B T cell resulted cross-strain protection IAV. key feature IAV-nanovax is its ability easily incorporate diverse proteins/payloads, potentially increasing provide broad and/or other pathogens. Due human susceptibility both H3N2 IAV, several nanovaccines were formulated herein with examine the "plug-and-play" nature platform determine their induce humoral cellular broad-based similar IAV-nanovax. H3N2-based formulations systemic mucosal responses associated antigen-specific antibodies. Additionally, lung-tissue resident CD4 CD8 enhanced post-vaccination. These immune corresponded homologous heterosubtypic infection. Overall, these results demonstrate plug-and-play generate utilizing payloads.

Language: Английский

Citations

2