ChemBioChem,
Journal Year:
2024,
Volume and Issue:
25(10)
Published: March 27, 2024
This
study
evaluated
the
potential
of
isoCoQ-Carbazole,
a
diheterocyclic
analog
isoCA-4,
as
an
anti-tumor
agent.
To
overcome
its
low
aqueous
solubility,
liposomes
were
developed
delivery
system
for
compound.
In
vitro
experiments
showed
that
loaded
exhibited
similar
activity
to
free
form
on
multiple
human
tumor
cell
lines.
vivo
using
palliative
intratumoral
injection
chemotherapy
approach
further
demonstrated
isoCoQ-Carbazole
significantly
reduced
growth
in
CA-4-resistant
HT29
model,
without
inducing
any
observable
toxicity
or
weight
loss
treated
mice.
These
findings
suggest
liposomal
may
hold
promise
therapeutic
agent
treatment
inoperable,
radiation-insensitive
cancers.
ACS Applied Nano Materials,
Journal Year:
2023,
Volume and Issue:
6(24), P. 22594 - 22610
Published: Dec. 4, 2023
Nanomedicines,
emerging
as
an
innovative
category
of
cancer
therapeutics,
have
garnered
increasing
attention
from
both
researchers
and
the
broader
public.
However,
despite
this
surge
in
interest,
a
focused
comprehensive
discussion
highlighting
their
distinct
advantages
over
small
molecule
drugs
remains
conspicuously
absent.
This
knowledge
gap
not
only
piques
curiosity
general
audience
but
also
leaves
engaged
these
investigations
with
partial
insights,
rather
than
understanding.
deficiency
represents
critical
juncture
that
demands
earnest
consideration.
In
light
context,
present
study
endeavors
to
consolidate
elucidate
unique
merits
nanomedicines,
particularly
contrast
traditional
drugs,
within
realm
treatment.
We
meticulously
summarized
14
nanomedicine,
alongside
recent
advanced
applications,
special
focus
on
past
three
years.
Our
objective
is
2-fold:
first,
provide
clear
understanding
facilitates
precise
design
second,
offer
nonspecialists
accessible
platform
for
grasping
concepts
establishing
strong
foundation
widespread
awareness.
essence,
our
aims
bridge
knowledge,
shedding
unparalleled
potential
nanomedicines
therapy,
we
believe
findings
hold
great
promise
advancing
scientific
research
public
field.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2464 - 2464
Published: Feb. 20, 2024
Glioblastoma
(GB)
is
the
most
aggressive
and
common
type
of
cancer
within
central
nervous
system
(CNS).
Despite
vast
knowledge
its
physiopathology
histology,
etiology
at
molecular
level
has
not
been
completely
understood.
Thus,
attaining
a
cure
possible
yet
it
remains
one
deadliest
types
cancer.
Usually,
GB
diagnosed
when
some
symptoms
have
already
presented
by
patient.
This
diagnosis
commonly
based
on
physical
exam
imaging
studies,
such
as
computed
tomography
(CT)
magnetic
resonance
(MRI),
together
with
or
followed
surgical
biopsy.
As
these
diagnostic
procedures
are
very
invasive
often
result
only
in
confirmation
presence,
necessary
to
develop
less
prognostic
tools
that
lead
earlier
treatment
increase
patients’
quality
life.
Therefore,
blood-based
biomarkers
(BBBs)
represent
excellent
candidates
this
context.
microRNAs
(miRNAs)
small,
non-coding
RNAs
demonstrated
be
stable
almost
all
body
fluids,
including
saliva,
serum,
plasma,
urine,
cerebrospinal
fluid
(CFS),
semen,
breast
milk.
In
addition,
serum-circulating
exosome-contained
miRNAs
successfully
used
better
classify
subtypes
make
choices
regarding
best
for
specific
cases.
Moreover,
regulate
multiple
target
genes
can
also
act
tumor
suppressors
oncogenes,
they
involved
appearance,
progression,
even
chemoresistance
tumors.
review,
we
discuss
how
dysregulated
early
prognosis
well
markers
subclassify
cases
provide
more
personalized
treatments,
which
may
response
against
GB.
therapeutic
potential
miRNAs,
current
challenges
their
clinical
application,
future
directions
field.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101457 - 101457
Published: Jan. 5, 2025
Central
nervous
system
(CNS)
diseases
are
a
major
cause
of
disability
and
death
worldwide.
Due
to
the
blood-brain
barrier
(BBB),
drug
delivery
for
CNS
is
extremely
challenging.
Nano-delivery
systems
can
overcome
limitations
BBB
deliver
drugs
CNS,
improve
ability
target
brain
provide
potential
therapeutic
methods
diseases.
At
same
time,
choice
different
(bypassing
or
crossing
BBB)
further
optimize
effect
nano-drug
system.
This
article
reviews
nano-delivery
way
enters
brain.
Different
kinds
nanoparticles
were
discussed
in
depth.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
11(7)
Published: Dec. 10, 2023
Early
clinical
diagnosis,
effective
intraoperative
guidance,
and
an
accurate
prognosis
can
lead
to
timely
medical
treatment.
The
current
conventional
methods
have
several
limitations.
Therefore,
there
is
a
need
develop
faster
more
reliable
detection,
treatment,
monitoring
enhance
their
applications.
Raman
spectroscopy
noninvasive
provides
highly
specific
information
about
the
molecular
structure
biochemical
composition
of
analytes
in
rapid
manner.
It
has
wide
range
applications
biomedicine,
materials,
settings.
This
review
primarily
focuses
on
application
medicine.
advantages
limitations
over
traditional
are
discussed.
In
addition,
combining
with
machine
learning,
nanoparticles,
probes
demonstrated,
thereby
extending
its
applicability
different
phases.
Examples
last
3
years
also
integrated.
Finally,
various
prospective
approaches
based
studies
surveyed,
challenges
Gels,
Journal Year:
2024,
Volume and Issue:
10(5), P. 307 - 307
Published: May 1, 2024
Nanostructured
lipid
carriers
(NLCs)
have
the
potential
to
increase
bioavailability
and
reduce
side
effects
of
docetaxel
(DTX).
However,
only
a
small
fraction
nanoparticles
given
intravenously
can
reach
solid
tumor.
In
situ-forming
gels
combined
with
facilitate
local
administration
promote
drug
retention
at
tumor
site.
Injectable
hydrogels
based
on
poloxamer
407
are
excellent
candidates
for
this
hybrid
nanoparticle-hydrogel
system
because
their
thermoresponsive
behavior
biocompatibility.
Therefore,
work
aimed
develop
injectable
containing
NLCs
intratumoral
delivery
DTX.
To
ensure
sterility,
obtained
were
autoclaved
(121
°C
15
min)
after
preparation.
Then,
incorporation
into
impact
steam
sterilization
nanocomposite
evaluated
concerning
sol-gel
transition,
injectability,
physicochemical
stability.
All
formulations
extruded
through
tested
syringe-needle
systems
acceptable
force
(2.2-13.4
N)
(49.5-317.7
N·mm)
injection.
Following
sterilization,
injection
became
easier
in
most
cases,
properties
all
remained
practically
unchanged
according
spectroscopical
thermal
analysis.
The
rheological
evaluation
revealed
that
liquid
25
underwent
rapid
gelation
37
°C.
sterilized
counterparts
gelled
1-2
above
body
temperature,
suggesting
autoclaving
conditions
employed
had
rendered
these
unsuitable
delivery.
Nanoscale Advances,
Journal Year:
2024,
Volume and Issue:
6(17), P. 4275 - 4308
Published: Jan. 1, 2024
Chemotherapy
and
surgery
remain
the
primary
treatment
modalities
for
cancers;
however,
these
techniques
have
drawbacks,
such
as
cancer
recurrence
toxic
side
effects,
necessitating
more
efficient
strategies.
Recent
advancements
in
research
medical
technology
provided
novel
insights
expanded
our
understanding
of
development;
consequently,
scholars
investigated
several
delivery
vehicles
therapy
to
improve
efficiency
patient
outcomes.
Herein,
we
summarize
types
smart
therapeutic
carriers
elaborate
on
mechanism
underlying
drug
delivery.
We
reveal
advantages
treatment,
focus
their
effectiveness
immunotherapy,
discuss
application
combination
with
other
emerging
strategies
treatment.
Finally,
bottlenecks
encountered
development
suggest
directions
future
research.
This
review
will
promote
progress
facilitate
related
BMEMat,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 25, 2024
Abstract
Nanomedicine
has
shown
promising
therapeutic
potential
in
cancer
treatment,
with
clinically
approved
formulations
such
as
Doxil®
and
Abraxane®
already
providing
tangible
benefits
to
patients.
However,
challenges
low
targeting
efficiency
poor
tumor
penetration
limit
its
application.
Bacteria
have
emerged
drug
delivery
carriers
due
their
capacity
for
autonomous
navigation
deep
into
hypoxic
parenchyma.
Therefore,
utilizing
bacteria
nanomedicine
can
partially
overcome
the
limitations
of
anti‐tumor
nanomedicine.
Moreover,
some
bacteria,
like
Salmonella
typhimurium
Escherichia
coli
,
exhibit
immunostimulatory
oncolytic
effects
synergistically
enhance
This
article
summarizes
common
types
nanomedicines
respective
advantages
treatment.
It
elaborates
on
various
strategies
combining
under
different
administration
routes,
outlining
clinical
progress
bacterial
therapy
outlooking
future
applications
International Journal of Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
664, P. 124623 - 124623
Published: Aug. 25, 2024
Docetaxel
(DTX)
is
a
recommended
treatment
in
patients
with
metastasic
prostate
cancer
(PCa),
despite
its
therapeutic
efficacy
limited
by
strong
systemic
toxicity.
However,
localized
PCa,
intratumoral
(IT)
administration
of
DTX
could
be
an
alternative
to
consider
that
may
help
overcome
the
disadvantages
conventional
intravenous
(IV)
therapy.
In
this
context,
we
here
present
first
vivo
preclinical
study
PCa
therapy
nanomedicines
mesoporous
silica
nanoparticles
(MSN)
and
IT
injection
over
xenograft
mouse
model
bearing
human
adenocarcinoma
tumors.
The
tolerability,
biodistribution
histopathology
after
have
been
investigated
for
nanomedicine
free
drug,
compared
IV
DTX.
obtained
results
demonstrate
allows
precise
selective
non-metastatic
minimize
diffusion
showing
superior
activity
than
route.
This
reducing
dose
one
order
widens
substantially
window
drug.
Furthermore,
use
as
promotes
antitumor
drug
accumulation
at
tumor
site,
improving
same
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 9, 2025
Despite
enormous
progress,
advanced
cancers
are
still
one
of
the
most
serious
medical
problems
in
current
society.
Although
various
agents
and
therapeutic
strategies
with
anticancer
activity
known
used,
they
often
fail
to
achieve
satisfactory
long-term
patient
outcomes
survival.
Recently,
immunotherapy
has
shown
success
patients
by
harnessing
important
interactions
between
immune
system
cancer.
However,
many
these
therapies
lead
frequent
side
effects
when
administered
systemically,
prompting
treatment
modifications
or
discontinuation
or,
severe
cases,
fatalities.
New
approaches
like
intratumoral
immunotherapy,
characterized
reduced
effects,
cost,
systemic
toxicity,
offer
promising
prospects
for
future
applications
clinical
oncology.
In
context
locally
metastatic
cancer,
combining
diverse
immunotherapeutic
other
targeting
multiple
cancer
hallmarks
appears
crucial.
Such
combination
hold
promise
improving
survival
promoting
a
sustained
response.
This
review
aims
provide
overview
approaches,
specifically
focusing
on
administration
drugs
cancers.
It
also
explores
integration
modalities
maximize
Additionally,
summarizes
recent
advances
discusses
novel
outlining
directions
field.
