Engineering in NIR‐responsive photothermal materials and their application in wound healing administration

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Abstract Wound healing is a complex process that involves multiple stages and susceptible to various challenges, such as infection, insufficient blood flow, the body's inadequate response process, which can be life‐threatening for patient. In current medical landscape, traditional treatments often struggle meet high standards of modern care. Therefore, it crucial actively explore develop new drugs or advanced technologies enhance bacterially infected wounds. recent years, several physical methods effectively accelerate wound have garnered widespread attention interest. Among these, Photothermal therapy (PTT) has been extensively utilized in treatment bacterial infections due its non‐invasive, low toxicity, ease use. The photothermal agents (PTAs) serve core material PTT, their efficacy significantly influenced by specific PTAs employed. Selecting appropriate essential achieving desired therapeutic effect. This relies on PTAs's ability efficiently convert wavelengths light energy into heat upon absorption, thereby generating thermal effect at site. Consequently, properties PTAs, including conversion efficiency, biocompatibility, stability within organism, are critical factors determine outcome. review introduces organic, inorganic, organic‐inorganic hybrid PTT healing, highlighting main applications management years. Finally, we briefly discuss limitations prospects this field.

Language: Английский

---

Treatment of Acute Wound Infections by Degradable Polymer Nanoparticle with a Synergistic Photothermal and Chemodynamic Strategy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(17)

Published: Feb. 26, 2024

Mild-heat photothermal antibacterial therapy avoids heat-induced damage to normal tissues but causes bacterial tolerance. The use of in synergy with chemodynamic is expected address this issue. Herein, two pseudo-conjugated polymers P

Language: Английский

---

Eumelanin‐Enhanced Photothermal Disinfection of Contact Lenses Using a Sustainable Marine Nanoplatform Engineered with Electrospun Nanofibers

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Abstract Bacterial keratitis (BK) is a severe eye infection commonly associated with Staphylococcus aureus (S. aureus) , posing significant risk to vision, especially among contact lens wearers. This research introduces novel smart nanoplatform (deMS@cNF), developed from demineralized mussel shells (deMS) and reinforced chitin (CT) nanofibrils, specifically designed for portable photothermal disinfection of lenses. The leverages the properties eumelanin in (MS), which, when activated by simple bike flashlight, rapidly heats temperatures up 95 °C, effectively destroying bacterial contamination. In vitro tests demonstrate that biocompatible non‐toxic, making it suitable medical applications. study highlights an innovative approach converting marine biowaste into safe, effective, low‐cost method disinfecting lenses, showcasing potential deMS@cNF platform broader antimicrobial

Language: Английский

---

Tailoring Phage Nanosomes for Enhanced Theranostic Properties of Near Infrared Dyes

Langmuir, Journal Year: 2024, Volume and Issue: 40(32), P. 16743 - 16756

Published: July 29, 2024

Near-infrared (NIR) phototherapies offer noninvasive, cost-effective solutions for treating tumors and microbial infections. However, organic NIR dyes commonly used suffer from solubility stability issues requiring frequent dosing. We address this challenge by exploring the bacteriophage-mediated enhancement of dye properties. Upon encapsulation within phage nanosomes, IR780 Indocyanine green (ICG), with similar optical properties but distinct water exhibit enhanced UV–vis absorbance photothermal transduction efficacy compared to liposomes. Experimental characterization corroborated all-atom molecular dynamics simulations imprints nanoscale structure, solubility, dynamics, binding these molecules membrane protein present in Phage capsid. These dye-loaded coencapsulated mitoxantrone, demonstrate anticancer activity, when combined amphotericin B, superior effects against fungal Our findings a simple efficient approach tuning performance existing through rational design therapeutic outcomes.

Language: Английский

---

Novel insights and future perspectives on the nanomedicine-mediated synergistic anticancer effect of the combination of ferroptosis and photothermal therapy

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156921 - 156921

Published: Oct. 1, 2024

Language: Английский

---

Biomaterials-based phototherapy for bacterial infections

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 4, 2024

Bacterial infections and antibiotic resistance are global health problems, current treatments for bacterial still rely on the use of antibiotics. Phototherapy based a photosensitizer has high efficiency, broad spectrum, strong selectivity, does not easily induce drug resistance, is expected to become an effective strategy treatment infections, particularly drug-resistant infections. This article reviews antimicrobial strategies phototherapy photosensitizers, including photodynamic therapy (PDT), photothermal (PTT), their combination. These methods have significant application potential in combating multi-drug-resistant biofilm providing alternative traditional antibiotics chemical antibacterial agents.

Language: Английский

---

Advanced techniques and nanotechnologies for point-of-care testing

Frontiers in Nanotechnology, Journal Year: 2025, Volume and Issue: 6

Published: Jan. 15, 2025

Hospitals and other healthcare facilities harbor a complex interplay of microbial pathogens. The correct understanding pathogens distribution evolution is therefore crucial for infections control the design effective prevention strategies. In parallel, integration cutting-edge nanotechnologies early detection monitoring these specific target considered most approach to face nosocomial infections. this context, point-of-care (POC) testing, also known as near-patient becoming increasingly important. review we provide systematic insight into recent scientific technological advances in pathogen that explore advanced realize devices nanobiosensors, with improved selectivity sensitivity. particular, report on diffused affordable developed still developing POC aim increase sensitivity, speed accuracy different environments, from intensive care units outside laboratory hospital settings. text sub-divided several sections, each one focused type nanomaterials techniques actually employed.

Language: Английский

---

Rational Design of Quinoidal Conjugated Polymers for Photothermal Antibacterial Therapy

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract The increasing prevalence of antibiotic resistance, driven by the overuse and misuse conventional antibiotics, has become a critical public health concern. Photothermal antibacterial therapy (PTAT) utilizes heat generated photothermal agents under light exposure to inhibit bacterial growth without inducing attracting more attention. Quinoid conjugated polymers, especially para‐azaquinodimethane (AQM) polymer, are class organic semiconductors known for efficient π‐electron delocalization, near‐infrared absorption, narrow bandgap, showing great potential in application reagents. However, current AQM polymers face challenges related their solubility, photostability, biocompability. In this study, tetraglycol is introduced onto core improving drawbacks resulting polymers. Two with different electron donor (thiophene 2,2'‐bithiophene) synthesized evaluated various properties. PAQMT exhibited superior performance, including higher extinction coefficients, improved greater stability repeated NIR irradiation. further developed into nanoparticles via encapsulation, excellent colloidal stability, effective inhibition 808 nm light. This work provides new strategy properties offers opportunities promoting quinoidal PTAT.

Language: Английский

---

Portable Acoustic Holographic Optical Waveguide Device for Phototherapy

ACS Photonics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Photodynamic therapy and photothermal have emerged as indispensable modalities to treat diseases. However, their efficacy is hindered by the substantial light scattering within tissues, preventing transmission effectively targeted lesion sites. Various existing devices aimed at mitigating typically exhibit invasiveness complexity. In this work, we propose an approach that utilizes a portable acoustic holographic optical waveguide device mitigate manipulating refractive index tissues. This manipulation allows in situ modulation of scattered light, thereby promoting concentration photon energy. We demonstrated can medium through simulation imaging experiments. Second, both photodynamic experiments enhance rate temperature rise singlet oxygen (1O2) generation, respectively. It foreseeable versatility overcoming augment outcomes phototherapy, offering noninvasive, portable, robust method.

Language: Английский

---

Augmented antibacterial performance of MoS2-integrated lignin-polyaniline composites through near-infrared stimulated photothermal and peroxidase-like activities

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141384 - 141384

Published: Feb. 21, 2025

Language: Английский

---