The clinical prospects and challenges of photothermal nanomaterials in myocardium recovery after myocardial infarction DOI Creative Commons
Jiali Yang, Jian He, Tian Yue

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 29, 2024

The high morbidity and mortality rates associated with myocardial infarction pose a serious threat to human health. Early diagnosis appropriate treatment are crucial in saving the lives of patients. In recent years, nanomaterials-based technologies have played significant role developing new strategies for cardiac repair, particularly use photothermal nanomaterials, which show great potential treating infarction. This review aims describe characteristics their effects on cardiomyocyte proliferation angiogenesis, mechanism tissue repair. serves as valuable reference application nanomaterials infarction, ultimate goal expediting translation these into clinical practice.

Language: Английский

Engineering in NIR‐responsive photothermal materials and their application in wound healing administration DOI Creative Commons
A. Bassam, Meng-Xuan Du, Yuan Li

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Abstract Wound healing is a complex process that involves multiple stages and susceptible to various challenges, such as infection, insufficient blood flow, the body's inadequate response process, which can be life‐threatening for patient. In current medical landscape, traditional treatments often struggle meet high standards of modern care. Therefore, it crucial actively explore develop new drugs or advanced technologies enhance bacterially infected wounds. recent years, several physical methods effectively accelerate wound have garnered widespread attention interest. Among these, Photothermal therapy (PTT) has been extensively utilized in treatment bacterial infections due its non‐invasive, low toxicity, ease use. The photothermal agents (PTAs) serve core material PTT, their efficacy significantly influenced by specific PTAs employed. Selecting appropriate essential achieving desired therapeutic effect. This relies on PTAs's ability efficiently convert wavelengths light energy into heat upon absorption, thereby generating thermal effect at site. Consequently, properties PTAs, including conversion efficiency, biocompatibility, stability within organism, are critical factors determine outcome. review introduces organic, inorganic, organic‐inorganic hybrid PTT healing, highlighting main applications management years. Finally, we briefly discuss limitations prospects this field.

Language: Английский

Citations

4
Treatment of Acute Wound Infections by Degradable Polymer Nanoparticle with a Synergistic Photothermal and Chemodynamic Strategy DOI Creative Commons
Fangzhou Chen,

Lin Liu,

Dongsheng Tang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(17)

Published: Feb. 26, 2024

Mild-heat photothermal antibacterial therapy avoids heat-induced damage to normal tissues but causes bacterial tolerance. The use of in synergy with chemodynamic is expected address this issue. Herein, two pseudo-conjugated polymers P

Language: Английский

Citations

12
Eumelanin‐Enhanced Photothermal Disinfection of Contact Lenses Using a Sustainable Marine Nanoplatform Engineered with Electrospun Nanofibers DOI
Magdalena Bartolewska, Alicja Kosik‐Kozioł, Zbigniew Korwek

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Abstract Bacterial keratitis (BK) is a severe eye infection commonly associated with Staphylococcus aureus (S. aureus) , posing significant risk to vision, especially among contact lens wearers. This research introduces novel smart nanoplatform (deMS@cNF), developed from demineralized mussel shells (deMS) and reinforced chitin (CT) nanofibrils, specifically designed for portable photothermal disinfection of lenses. The leverages the properties eumelanin in (MS), which, when activated by simple bike flashlight, rapidly heats temperatures up 95 °C, effectively destroying bacterial contamination. In vitro tests demonstrate that biocompatible non‐toxic, making it suitable medical applications. study highlights an innovative approach converting marine biowaste into safe, effective, low‐cost method disinfecting lenses, showcasing potential deMS@cNF platform broader antimicrobial

Language: Английский

Citations

6
Novel insights and future perspectives on the nanomedicine-mediated synergistic anticancer effect of the combination of ferroptosis and photothermal therapy DOI
Haisong Qi, Haiying Wang, Lu Wang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156921 - 156921

Published: Oct. 1, 2024

Language: Английский

Citations

4
Advanced techniques and nanotechnologies for point-of-care testing DOI Creative Commons
Valeria Secchi, Alice Armanni, Linda Barbieri

et al.

Frontiers in Nanotechnology, Journal Year: 2025, Volume and Issue: 6

Published: Jan. 15, 2025

Hospitals and other healthcare facilities harbor a complex interplay of microbial pathogens. The correct understanding pathogens distribution evolution is therefore crucial for infections control the design effective prevention strategies. In parallel, integration cutting-edge nanotechnologies early detection monitoring these specific target considered most approach to face nosocomial infections. this context, point-of-care (POC) testing, also known as near-patient becoming increasingly important. review we provide systematic insight into recent scientific technological advances in pathogen that explore advanced realize devices nanobiosensors, with improved selectivity sensitivity. particular, report on diffused affordable developed still developing POC aim increase sensitivity, speed accuracy different environments, from intensive care units outside laboratory hospital settings. text sub-divided several sections, each one focused type nanomaterials techniques actually employed.

Language: Английский

Citations

0
Rational Design of Quinoidal Conjugated Polymers for Photothermal Antibacterial Therapy DOI Open Access
Zhang‐Cheng Hao, Hailin Zhou, Dong Gao

et al.

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract The increasing prevalence of antibiotic resistance, driven by the overuse and misuse conventional antibiotics, has become a critical public health concern. Photothermal antibacterial therapy (PTAT) utilizes heat generated photothermal agents under light exposure to inhibit bacterial growth without inducing attracting more attention. Quinoid conjugated polymers, especially para‐azaquinodimethane (AQM) polymer, are class organic semiconductors known for efficient π‐electron delocalization, near‐infrared absorption, narrow bandgap, showing great potential in application reagents. However, current AQM polymers face challenges related their solubility, photostability, biocompability. In this study, tetraglycol is introduced onto core improving drawbacks resulting polymers. Two with different electron donor (thiophene 2,2'‐bithiophene) synthesized evaluated various properties. PAQMT exhibited superior performance, including higher extinction coefficients, improved greater stability repeated NIR irradiation. further developed into nanoparticles via encapsulation, excellent colloidal stability, effective inhibition 808 nm light. This work provides new strategy properties offers opportunities promoting quinoidal PTAT.

Language: Английский

Citations

0
Portable Acoustic Holographic Optical Waveguide Device for Phototherapy DOI

R. Wang,

Qibo Lin, Zhaoxi Li

et al.

ACS Photonics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Photodynamic therapy and photothermal have emerged as indispensable modalities to treat diseases. However, their efficacy is hindered by the substantial light scattering within tissues, preventing transmission effectively targeted lesion sites. Various existing devices aimed at mitigating typically exhibit invasiveness complexity. In this work, we propose an approach that utilizes a portable acoustic holographic optical waveguide device mitigate manipulating refractive index tissues. This manipulation allows in situ modulation of scattered light, thereby promoting concentration photon energy. We demonstrated can medium through simulation imaging experiments. Second, both photodynamic experiments enhance rate temperature rise singlet oxygen (1O2) generation, respectively. It foreseeable versatility overcoming augment outcomes phototherapy, offering noninvasive, portable, robust method.

Language: Английский

Citations

0
Augmented antibacterial performance of MoS2-integrated lignin-polyaniline composites through near-infrared stimulated photothermal and peroxidase-like activities DOI
Jiankang Liu, Yong Qian, Guo‐Hua Hu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141384 - 141384

Published: Feb. 21, 2025

Language: Английский

Citations

0
Light Irradiation of N‐Doped Graphene Acid: Metal‐Free Strategy Toward Antibacterial and Antiviral Coatings With Dual Modes of Action DOI Creative Commons
Giacomo Reina, David Panáček,

Krista Rathammer

et al.

EcoMat, Journal Year: 2025, Volume and Issue: 7(4)

Published: March 26, 2025

ABSTRACT The increasing emergence of antimicrobial resistance and the development new infective viral strains represent a constantly growing threat. Metal‐based nanomaterials have emerged as promising tools in fight against bacterial infections; however, release metal nanoparticles/ions clinical applications may cause undesired side effects (allergies, systemic toxicity), reducing their practical use treatment. Moreover, metal‐based nanoparticles possess predominantly antibacterial effects, while antiviral efficiency remains controversial. Thus, metal‐free strategies enabling combined antibacterial/antiviral properties is significant challenge. Here, we report strategy based on light irradiation nitrogen‐doped graphene acid (NGA) possessing dual photothermal photodynamic modes action. activity activated through clinically approved near‐infrared (NIR) source, both spreading can be hampered coating scale minutes (5 to 10 min). developed reduced 90.9% 99.99% for S. aureus P. aeruginosa , respectively, well 99.97% murine hepatitis virus. Importantly, this research represents advancement safe, metal‐free, effective treatments. NGA coatings are safe skin, showing no sensitization or irritation, offer potential advanced

Language: Английский

Citations

0
Carbomer Hydrogel Composed of Cu2O and Hematoporphyrin Monomethyl Ether Promotes the Healing of Infected Wounds DOI Creative Commons
Dongyu Wang, Jiale Jin,

Chengran Zhang

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(4), P. 4974 - 4985

Published: Jan. 16, 2024

Infectious wounds pose a significant challenge in the field of wound healing primarily due to persistent inflammation and emergence antibiotic-resistant bacteria. To combat these issues, development an effective dressing that can prevent infection promote is utmost importance. Photodynamic therapy (PDT) has emerged as promising noninvasive treatment strategy for tackling A biodegradable photosensitizer called hematoporphyrin monomethyl ether (HMME) shown potential generating reactive oxygen species (ROS) upon laser activation However, insolubility HMME limits its antibacterial efficacy ability facilitate skin healing. overcome limitations, we have synthesized compound hydrogel by combining carbomer, HMME, Cu2O nanoparticles. This exhibits enhanced antimicrobial excellent biocompatibility promotes angiogenesis, which crucial defects. By integrating benefits nanoparticles, gel-forming properties this shows great material. In summary, developed study offers solution infectious addressing challenges prevention promoting innovative approach utilizing PDT unique could significantly improve outcomes clinical settings.

Language: Английский

Citations

2