Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Oct. 29, 2024
The
high
morbidity
and
mortality
rates
associated
with
myocardial
infarction
pose
a
serious
threat
to
human
health.
Early
diagnosis
appropriate
treatment
are
crucial
in
saving
the
lives
of
patients.
In
recent
years,
nanomaterials-based
technologies
have
played
significant
role
developing
new
strategies
for
cardiac
repair,
particularly
use
photothermal
nanomaterials,
which
show
great
potential
treating
infarction.
This
review
aims
describe
characteristics
their
effects
on
cardiomyocyte
proliferation
angiogenesis,
mechanism
tissue
repair.
serves
as
valuable
reference
application
nanomaterials
infarction,
ultimate
goal
expediting
translation
these
into
clinical
practice.
Langmuir,
Journal Year:
2024,
Volume and Issue:
40(32), P. 16743 - 16756
Published: July 29, 2024
Near-infrared
(NIR)
phototherapies
offer
noninvasive,
cost-effective
solutions
for
treating
tumors
and
microbial
infections.
However,
organic
NIR
dyes
commonly
used
suffer
from
solubility
stability
issues
requiring
frequent
dosing.
We
address
this
challenge
by
exploring
the
bacteriophage-mediated
enhancement
of
dye
properties.
Upon
encapsulation
within
phage
nanosomes,
IR780
Indocyanine
green
(ICG),
with
similar
optical
properties
but
distinct
water
exhibit
enhanced
UV–vis
absorbance
photothermal
transduction
efficacy
compared
to
liposomes.
Experimental
characterization
corroborated
all-atom
molecular
dynamics
simulations
imprints
nanoscale
structure,
solubility,
dynamics,
binding
these
molecules
membrane
protein
present
in
Phage
capsid.
These
dye-loaded
coencapsulated
mitoxantrone,
demonstrate
anticancer
activity,
when
combined
amphotericin
B,
superior
effects
against
fungal
Our
findings
a
simple
efficient
approach
tuning
performance
existing
through
rational
design
therapeutic
outcomes.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 4, 2024
Bacterial
infections
and
antibiotic
resistance
are
global
health
problems,
current
treatments
for
bacterial
still
rely
on
the
use
of
antibiotics.
Phototherapy
based
a
photosensitizer
has
high
efficiency,
broad
spectrum,
strong
selectivity,
does
not
easily
induce
drug
resistance,
is
expected
to
become
an
effective
strategy
treatment
infections,
particularly
drug-resistant
infections.
This
article
reviews
antimicrobial
strategies
phototherapy
photosensitizers,
including
photodynamic
therapy
(PDT),
photothermal
(PTT),
their
combination.
These
methods
have
significant
application
potential
in
combating
multi-drug-resistant
biofilm
providing
alternative
traditional
antibiotics
chemical
antibacterial
agents.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 8, 2024
Abstract
Sonothermal
therapy
(STT)
has
become
increasingly
attractive
recently
as
a
noninvasive,
safe,
and
nonionizing
methodology.
STT,
newly
emerging
heat‐enabled
therapeutic
approach,
can
rely
on
built‐in
bubble
cavitation
thermal
energy‐electron
recombination
of
sonothermal
agents
(STAs)
activated
by
ultrasound
(US)
irradiation.
In
this
domain,
STT‐enabled
nanomedicine
is
considered
potential
treatment
for
abnormal
cell
killing
normal
renewing,
which
addresses
the
drawbacks
nonspecific
heating
in
conventional
microbubbles,
side
effects,
poor
tissue
penetration
available
thermal‐based
therapies.
Herein,
comprehensive
review
efficiency
STT
tumor
ablation,
infection
therapy,
regeneration
presented.
Moreover,
focuses
benefits
hot
topic
that
be
used
nonantibiotic
treatments,
noninvasive
heat‐activated
regeneration,
highly
efficient
local
cancer
therapy.
addition,
rational
design
STAs,
mechanistic
innovations,
prospects
will
also
provided.
Photothermal
therapy
(PTT)
provides
a
great
prospect
for
noninvasive
cancer
therapy.
However,
it
is
still
highly
challenging
to
construct
photothermal
agents
(PTAs)
with
the
desired
performances
imaging-guided
PTT
applications.
Herein,
D-A-D-type
naphthalene
diamine
(NDI)-based
nano-PTAs
NDS-BPN
NP
near-infrared
region
(NIR)
emission
at
822
nm,
aggregation-induced
(AIE),
high
conversion
efficiency
(55.05%),
and
excellent
stability
successfully
designed
prepared
through
simple
two-step
engineering
method
by
using
new
AIE
molecule
DSPE-PEG2000
as
precursors.
The
nanoagents
NPs
have
been
further
applied
efficient
ablation
of
cells
in
vitro
also
achieved
NIR
fluorescent
image-guided
tumor
vivo
satisfactory
results.
We
believe
that
this
work
an
attractive
NDI-based
nano-PTA
phototherapy
tumors
well
develops
construction
strategy
NDI
molecular-based
PTT.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(19), P. 3998 - 3998
Published: Oct. 5, 2023
L-ornithine
and
L-glutamine
are
amino
acids
used
for
ammonia
nitrogen
transport
in
the
human
body.
Novel
biodegradable
synthetic
poly(lactic-co-glycolic
acid)
derivatives
were
synthesized
via
conjugation
with
or
L-glutamine,
which
selected
due
to
their
biological
importance.
was
integrated
into
a
PLGA
polymer
EDC
coupling
reactions
as
structure
developer
after
synthesis
of
polycondensation
ring-opening
polymerization
lactide
glycolide.
The
chemical,
thermal,
degradation
property–structure
relationships
PLGA,
PLGA-L-ornithine,
PLGA-L-glutamine
identified.
between
acid
confirmed
through
observation
an
increase
number
carbonyl
carbons
range
170–160
ppm
13C
NMR
spectrum
signal
amide
vibration
at
about
1698
cm−1
FTIR
spectrum.
developed
PLGA-L-ornithine
thermally
stable
energetic
materials.
In
addition,
PLGA-L-glutamine,
unique
hydrophilic
properties,
had
faster
times
than
terms
surface-type
erosion,
covers
requirements.
L-ornithine-
L-glutamine-linked
PLGAs
potential
candidates
development
PLGA-derived
biopolymers
that
can
be
raw
materials
biomaterials.
Macromolecular Bioscience,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 16, 2024
Controlling
infections
while
reducing
the
use
of
antibiotics
is
what
doctors
as
well
researchers
are
looking
for.
As
innovative
smart
materials,
photothermal
materials
can
achieve
localized
heating
under
light
excitation
for
broad-spectrum
bacterial
inhibition.
A
polydopamine/chitosan/β-glycerophosphate
temperature-sensitive
hydrogel
with
excellent
antibacterial
ability
synthesized
here.
Initially,
has
good
biocompatibility.
In
vitro
experiments
reveal
its
noncytotoxic
property
when
cocultured
gingival
fibroblasts
and
nonhemolytic
capability.
Concurrently,
in
vivo
biocompatibility
confirmed
through
liver
kidney
blood
markers
staining
key
organs.
Crucially,
conversion
performance,
which
realize
up
to
3
mm
thickness.
When
excited
by
near-infrared
light,
attainable,
resulting
clear
inhibition
impacts
on
both
Staphylococcus
aureus
Escherichia
coli,
rates
91.22%
96.69%,
respectively.
During
studies
mice's
infected
wounds,
it
observed
that
decrease
S.
aureus'
presence
affected
area
exposed
also
lessen
initial
inflammation
apoptosis,
hastening
tissue
healing.
These
findings
provide
valuable
insights
into
design
antibiotic-free
novel
biomaterials
potential
clinical
applications.
