Optimizing the benefit–risk trade-off in nano-agrochemicals through explainable machine learning: beyond concentration

Environmental Science Nano, Journal Year: 2024, Volume and Issue: 11(8), P. 3374 - 3389

Published: Jan. 1, 2024

An explainable ML-driven MOO approach is proposed for the benefit–risk trade-off of nano-agrochemicals. Results highlight importance considering well-known concentration-dependent effect in conjunction with other key factors.

Language: Английский

Nanotoxicology: developments and new insights

Nanomedicine, Journal Year: 2024, Volume and Issue: 20(2), P. 225 - 241

Published: Dec. 26, 2024

The use of nanoparticles (NPs) in treatment diseases have increased exponentially recently, giving rise to the science nanomedicine. safety these NPs humans has also led nanotoxicology. Due a dearth both readily available models and precise bio-dispersion characterization techniques, nanotoxicological research obviously been constrained. However, ensuing years were notable for emergence improved synthesis methods tools. Major advances made linking certain physical variables, paralleling improvements size, shape, or coating factors resulting physiological reactions. Although significant progress contribution development nanotoxicology, however, it faces numerous difficulties technical constraints distinct from those conventional toxicological assessment as attempts improve therapeutic effects medicines. Determining thorough standards, standardizing dosimetry, assessing kinetics ions dissolving enhancing accuracy vitro-in vivo correlation efficiency, defining restrictions on exposure protection are some most important pressing concerns. This article will explore past advancement potential prospects standard models, emphasizing findings earlier studies examining current challenges, insight way forward.

Language: Английский

Evidence for low bioavailability of dietary nanoparticulate cerium in a freshwater food chain

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 279, P. 107228 - 107228

Published: Dec. 28, 2024

Language: Английский