The Role of ETNPPL in Dopaminergic Neuron Stability: Insights from Neuromelanin-Associated Protein Expression in Parkinson’s Disease DOI Open Access
Francesca A. Schillaci, Giuseppe Lanza, Maria Grazia Salluzzo

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 13107 - 13107

Published: Dec. 6, 2024

More than six million people worldwide are affected by Parkinson's disease (PD), a multifactorial disorder characterized the progressive loss of dopaminergic neurons in substantia nigra pars compacta (SNc). Several immunohistochemical studies suggest that neuromelanin (NM), found these neurons, plays key role their degeneration. In this study, twelve formalin-fixed, paraffin-embedded (FFPE) brain sections were analyzed, comprising samples from PD patients and healthy controls. Immunohistochemistry (IHC) was conducted to assess expression ETNPPL protein samples. detected both control Additionally, we examined mRNA using Quantitative Real-Time PCR (qRT-PCR) same sample set. Notably, samples, closely associated with dark NM pigment cytoplasm SNc neurons. contrast, showed weak cytoplasmic ETNPPL, no association pigment. No nuclear signal either or qRT-PCR results revealed lower individual compared Importantly, observed higher concentration at level controls, consistent patterns. These findings potential for normal function underscore its altered disease.

Language: Английский

Comparison of Aptamer and Antibody Bioreceptors in the OEGFET Biosensor Platform for Detecting α-Synuclein, a Parkinson's Biomarker DOI
Roslyn S. Massey, S. Johri, Dennis Chan

et al.

IEEE Sensors Letters, Journal Year: 2024, Volume and Issue: 8(7), P. 1 - 4

Published: June 12, 2024

Language: Английский

Citations

0
Biosensing systems for the detection of biomarkers of neurodegenerative diseases: a review DOI
Z Zielińska, Łukasz Ołdak, Ewa Gorodkiewicz

et al.

Talanta, Journal Year: 2024, Volume and Issue: 284, P. 127247 - 127247

Published: Nov. 19, 2024

Language: Английский

Citations

0
The Role of ETNPPL in Dopaminergic Neuron Stability: Insights from Neuromelanin-Associated Protein Expression in Parkinson’s Disease DOI Open Access
Francesca A. Schillaci, Giuseppe Lanza, Maria Grazia Salluzzo

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 13107 - 13107

Published: Dec. 6, 2024

More than six million people worldwide are affected by Parkinson's disease (PD), a multifactorial disorder characterized the progressive loss of dopaminergic neurons in substantia nigra pars compacta (SNc). Several immunohistochemical studies suggest that neuromelanin (NM), found these neurons, plays key role their degeneration. In this study, twelve formalin-fixed, paraffin-embedded (FFPE) brain sections were analyzed, comprising samples from PD patients and healthy controls. Immunohistochemistry (IHC) was conducted to assess expression ETNPPL protein samples. detected both control Additionally, we examined mRNA using Quantitative Real-Time PCR (qRT-PCR) same sample set. Notably, samples, closely associated with dark NM pigment cytoplasm SNc neurons. contrast, showed weak cytoplasmic ETNPPL, no association pigment. No nuclear signal either or qRT-PCR results revealed lower individual compared Importantly, observed higher concentration at level controls, consistent patterns. These findings potential for normal function underscore its altered disease.

Language: Английский

Citations

0